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Periodontitis is associated with airflow obstruction in the Malmö Offspring Dental Study

Røsland, Anders ; Bertelsen, Randi J. ; Bunæs, Dagmar F. ; Drengenes, Christine ; Engström, Gunnar LU ; Klinge, Bjørn ; Lie, Stein Atle ; Nilsson, Peter M. LU ; Jönsson, Daniel LU and Malinovschi, Andrei (2024) In Journal of Clinical Periodontology 51(1). p.86-96
Abstract

Aim: To investigate the association between periodontitis and lung function in the Malmö Offspring Dental Study. Materials and Methods: In all 1001 individuals (49.9% female, mean age: 44.6) from Malmö Offspring Dental Study were included. Periodontitis was assessed by a full-mouth examination protocol including bleeding on probing and classified according to the American Academy of Periodontology/Center for Disease Control definitions. Forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) were expressed as absolute values and %predicted according to Global Lung Function Initiative reference values. FEV1, FVC and FEV1/FVC were analysed in relation to periodontal status using linear... (More)

Aim: To investigate the association between periodontitis and lung function in the Malmö Offspring Dental Study. Materials and Methods: In all 1001 individuals (49.9% female, mean age: 44.6) from Malmö Offspring Dental Study were included. Periodontitis was assessed by a full-mouth examination protocol including bleeding on probing and classified according to the American Academy of Periodontology/Center for Disease Control definitions. Forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) were expressed as absolute values and %predicted according to Global Lung Function Initiative reference values. FEV1, FVC and FEV1/FVC were analysed in relation to periodontal status using linear regression. Results: Severe periodontitis was found in 7% of the population. Adjusted regression models showed significant associations between lung function and severe periodontitis with 2.1 unit lower FEV1/FVC ratio (95% CI: −3.91, –0.23) and odds ratio (adjusted) of 2.56 (95% CI: 1.40, 4.75, p =.003) for airflow obstruction (FEV1/FVC less than the lower limit of normal) if having severe periodontitis. Lower values of %predicted FEV1 and %predicted FVC, but not FEV1/FVC, were found in individuals with >25% bleeding on probing. Conclusions: Severe periodontitis was associated with lower FEV1/FVC ratio and airflow obstruction in the present cohort. More large-scale prospective studies and intervention studies are required for a comprehensive evaluation.

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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
lung function, Malmö Offspring Dental Study, periodontal disease, periodontitis, pulmonary function
in
Journal of Clinical Periodontology
volume
51
issue
1
pages
86 - 96
publisher
Wiley-Blackwell
external identifiers
  • pmid:37837290
  • scopus:85174186618
ISSN
0303-6979
DOI
10.1111/jcpe.13886
language
English
LU publication?
yes
id
4b72cc4c-4693-4668-bc28-6e8f9f2c9d75
date added to LUP
2023-12-14 15:08:10
date last changed
2024-04-13 07:15:06
@article{4b72cc4c-4693-4668-bc28-6e8f9f2c9d75,
  abstract     = {{<p>Aim: To investigate the association between periodontitis and lung function in the Malmö Offspring Dental Study. Materials and Methods: In all 1001 individuals (49.9% female, mean age: 44.6) from Malmö Offspring Dental Study were included. Periodontitis was assessed by a full-mouth examination protocol including bleeding on probing and classified according to the American Academy of Periodontology/Center for Disease Control definitions. Forced expiratory volume in 1 s (FEV<sub>1</sub>) and forced vital capacity (FVC) were expressed as absolute values and %predicted according to Global Lung Function Initiative reference values. FEV<sub>1</sub>, FVC and FEV<sub>1</sub>/FVC were analysed in relation to periodontal status using linear regression. Results: Severe periodontitis was found in 7% of the population. Adjusted regression models showed significant associations between lung function and severe periodontitis with 2.1 unit lower FEV<sub>1</sub>/FVC ratio (95% CI: −3.91, –0.23) and odds ratio (adjusted) of 2.56 (95% CI: 1.40, 4.75, p =.003) for airflow obstruction (FEV<sub>1</sub>/FVC less than the lower limit of normal) if having severe periodontitis. Lower values of %predicted FEV<sub>1</sub> and %predicted FVC, but not FEV<sub>1</sub>/FVC, were found in individuals with &gt;25% bleeding on probing. Conclusions: Severe periodontitis was associated with lower FEV<sub>1</sub>/FVC ratio and airflow obstruction in the present cohort. More large-scale prospective studies and intervention studies are required for a comprehensive evaluation.</p>}},
  author       = {{Røsland, Anders and Bertelsen, Randi J. and Bunæs, Dagmar F. and Drengenes, Christine and Engström, Gunnar and Klinge, Bjørn and Lie, Stein Atle and Nilsson, Peter M. and Jönsson, Daniel and Malinovschi, Andrei}},
  issn         = {{0303-6979}},
  keywords     = {{lung function; Malmö Offspring Dental Study; periodontal disease; periodontitis; pulmonary function}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{86--96}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Journal of Clinical Periodontology}},
  title        = {{Periodontitis is associated with airflow obstruction in the Malmö Offspring Dental Study}},
  url          = {{http://dx.doi.org/10.1111/jcpe.13886}},
  doi          = {{10.1111/jcpe.13886}},
  volume       = {{51}},
  year         = {{2024}},
}