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Arterial stiffness and incidence of diabetes : A population-based cohort study

Muhammad, Iram Faqir LU ; Borné, Yan LU ; Östling, Gerd LU ; Kennbäck, Cecilia; Gottsäter, Mikael LU ; Persson, Margaretha LU ; Nilsson, Peter M. LU and Engström, Gunnar LU (2017) In Diabetes Care 40(12). p.1739-1745
Abstract

Objective: Diabetes is known to be associated with increased arterial stiffness. However, the temporal association between increased carotid-femoral pulse wave velocity (c-f PWV) and diabetes is unclear. The aim of this study is to explore the relationship between arterial stiffness, as determined by c-f PWV, and incidence of diabetes. Research Design and Methods: The study population included participants from the Malmö Diet and Cancer cardiovascular cohort, using measurements from the 2007-2012 reexamination as baseline. Arterial stiffness was evaluated by measuring c-f PWV (SphygmoCor). After excluding participants with prevalent diabetes (according to measurements of fasting glucose, oral glucose tolerance tests, and physician's... (More)

Objective: Diabetes is known to be associated with increased arterial stiffness. However, the temporal association between increased carotid-femoral pulse wave velocity (c-f PWV) and diabetes is unclear. The aim of this study is to explore the relationship between arterial stiffness, as determined by c-f PWV, and incidence of diabetes. Research Design and Methods: The study population included participants from the Malmö Diet and Cancer cardiovascular cohort, using measurements from the 2007-2012 reexamination as baseline. Arterial stiffness was evaluated by measuring c-f PWV (SphygmoCor). After excluding participants with prevalent diabetes (according to measurements of fasting glucose, oral glucose tolerance tests, and physician's diagnoses), the final study population consisted of 2,450 individuals (mean age = 71.965.6 years). Incidence of diabetes was followed by linkage to local and national diabetes registers. Cox proportional hazards regression was used to assess the incidence of diabetes in relation to the tertiles of c-f PWV, adjusted for potential confounders. Results: During a mean follow-up of 4.43 6 1.40 years, 68 (2.8%) participants developed diabetes. Crude incidence of diabetes (per 1,000 person-years) was 3.5, 5.7, and 9.5, respectively, for subjects in the first, second, and third tertiles of c-f PWV. After adjustment for potential confounders, the hazard ratio of diabetes was 1.00 (reference), 1.83 (95% CI 0.88-3.8), and 3.24 (95% CI 1.51-6.97), respectively, for the tertiles of c-f PWV (P for trend = 0.002). Conclusions: Increased c-fPWV is associated with increased incidence of diabetes, independent of other risk factors. These results suggest that increased arterial stiffness is an early risk marker for developing diabetes.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetes Care
volume
40
issue
12
pages
7 pages
publisher
American Diabetes Association
external identifiers
  • scopus:85036618443
  • wos:000415868000023
ISSN
0149-5992
DOI
10.2337/dc17-1071
language
English
LU publication?
yes
id
4c10acf0-147c-47b9-86ec-b407c859a97d
date added to LUP
2017-12-18 09:01:39
date last changed
2018-05-29 10:02:28
@article{4c10acf0-147c-47b9-86ec-b407c859a97d,
  abstract     = {<p>Objective: Diabetes is known to be associated with increased arterial stiffness. However, the temporal association between increased carotid-femoral pulse wave velocity (c-f PWV) and diabetes is unclear. The aim of this study is to explore the relationship between arterial stiffness, as determined by c-f PWV, and incidence of diabetes. Research Design and Methods: The study population included participants from the Malmö Diet and Cancer cardiovascular cohort, using measurements from the 2007-2012 reexamination as baseline. Arterial stiffness was evaluated by measuring c-f PWV (SphygmoCor). After excluding participants with prevalent diabetes (according to measurements of fasting glucose, oral glucose tolerance tests, and physician's diagnoses), the final study population consisted of 2,450 individuals (mean age = 71.965.6 years). Incidence of diabetes was followed by linkage to local and national diabetes registers. Cox proportional hazards regression was used to assess the incidence of diabetes in relation to the tertiles of c-f PWV, adjusted for potential confounders. Results: During a mean follow-up of 4.43 6 1.40 years, 68 (2.8%) participants developed diabetes. Crude incidence of diabetes (per 1,000 person-years) was 3.5, 5.7, and 9.5, respectively, for subjects in the first, second, and third tertiles of c-f PWV. After adjustment for potential confounders, the hazard ratio of diabetes was 1.00 (reference), 1.83 (95% CI 0.88-3.8), and 3.24 (95% CI 1.51-6.97), respectively, for the tertiles of c-f PWV (P for trend = 0.002). Conclusions: Increased c-fPWV is associated with increased incidence of diabetes, independent of other risk factors. These results suggest that increased arterial stiffness is an early risk marker for developing diabetes.</p>},
  author       = {Muhammad, Iram Faqir and Borné, Yan and Östling, Gerd and Kennbäck, Cecilia and Gottsäter, Mikael and Persson, Margaretha and Nilsson, Peter M. and Engström, Gunnar},
  issn         = {0149-5992},
  language     = {eng},
  month        = {12},
  number       = {12},
  pages        = {1739--1745},
  publisher    = {American Diabetes Association},
  series       = {Diabetes Care},
  title        = {Arterial stiffness and incidence of diabetes : A population-based cohort study},
  url          = {http://dx.doi.org/10.2337/dc17-1071},
  volume       = {40},
  year         = {2017},
}