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Nerve repair and axonal transport. Distribution of axonally transported proteins during maturation period in regenerating rabbit hypoglossal nerve

Danielsen, N LU ; Lundborg, G LU and Frizell, M (1986) In Journal of the Neurological Sciences 73(3). p.77-269
Abstract

The distribution of fast migrating [3H]leucine-labelled proteins was studied in transected and repaired rabbit hypoglossal nerves. The nerves were repaired 90 days earlier with mesothelial chamber or epineurial suture technique. Fast migrating radiolabelled proteins were transported into the distal nerve segment and neurophysiological recordings from the tongue as well as the presence of myelinated axons in the distal nerve segment verified successful regeneration. The total amount of radioactivity was increased in repaired nerves as compared to contralateral nerves. In both groups there was a significant accumulation of radiolabelled proteins at the site of lesion. Nerves repaired with mesothelial chambers showed significantly more... (More)

The distribution of fast migrating [3H]leucine-labelled proteins was studied in transected and repaired rabbit hypoglossal nerves. The nerves were repaired 90 days earlier with mesothelial chamber or epineurial suture technique. Fast migrating radiolabelled proteins were transported into the distal nerve segment and neurophysiological recordings from the tongue as well as the presence of myelinated axons in the distal nerve segment verified successful regeneration. The total amount of radioactivity was increased in repaired nerves as compared to contralateral nerves. In both groups there was a significant accumulation of radiolabelled proteins at the site of lesion. Nerves repaired with mesothelial chambers showed significantly more radioactivity in the distal nerve segment as compared to sutured nerves. The present study indicates long-standing effects on axonal transport system after both types of nerve repair. It is our opinion that axonal transport studies are a valuable complement when evaluating experimental nerve repair.

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organization
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publication status
published
subject
keywords
Animals, Axonal Transport, Female, Hypoglossal Nerve, Hypoglossal Nerve Injuries, Male, Nerve Regeneration, Nerve Tissue Proteins, Rabbits, Journal Article, Research Support, Non-U.S. Gov't
in
Journal of the Neurological Sciences
volume
73
issue
3
pages
77 - 269
publisher
Elsevier
external identifiers
  • scopus:0022497204
ISSN
0022-510X
DOI
10.1016/0022-510X(86)90151-6
language
English
LU publication?
yes
id
4d1d4ce9-4622-4a9c-806c-86d47265ae90
date added to LUP
2017-10-13 14:11:44
date last changed
2017-10-16 10:42:23
@article{4d1d4ce9-4622-4a9c-806c-86d47265ae90,
  abstract     = {<p>The distribution of fast migrating [3H]leucine-labelled proteins was studied in transected and repaired rabbit hypoglossal nerves. The nerves were repaired 90 days earlier with mesothelial chamber or epineurial suture technique. Fast migrating radiolabelled proteins were transported into the distal nerve segment and neurophysiological recordings from the tongue as well as the presence of myelinated axons in the distal nerve segment verified successful regeneration. The total amount of radioactivity was increased in repaired nerves as compared to contralateral nerves. In both groups there was a significant accumulation of radiolabelled proteins at the site of lesion. Nerves repaired with mesothelial chambers showed significantly more radioactivity in the distal nerve segment as compared to sutured nerves. The present study indicates long-standing effects on axonal transport system after both types of nerve repair. It is our opinion that axonal transport studies are a valuable complement when evaluating experimental nerve repair.</p>},
  author       = {Danielsen, N and Lundborg, G and Frizell, M},
  issn         = {0022-510X},
  keyword      = {Animals,Axonal Transport,Female,Hypoglossal Nerve,Hypoglossal Nerve Injuries,Male,Nerve Regeneration,Nerve Tissue Proteins,Rabbits,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  number       = {3},
  pages        = {77--269},
  publisher    = {Elsevier},
  series       = {Journal of the Neurological Sciences},
  title        = {Nerve repair and axonal transport. Distribution of axonally transported proteins during maturation period in regenerating rabbit hypoglossal nerve},
  url          = {http://dx.doi.org/10.1016/0022-510X(86)90151-6},
  volume       = {73},
  year         = {1986},
}