Familial [corrected] transmission of coronary heart disease: a cohort study of 80,214 Swedish adoptees linked to their biological and adoptive parents.
Sundquist, Kristina LU ; Winkleby, Marilyn LU ; Li, Xinjun LU ; Ji, Jianguang LU
; Hemminki, Kari
LU
and Sundquist, Jan
LU
(2011)
In American Heart Journal
162(2).
p.317-323
- Abstract
- BACKGROUND:
Studies of adoptees have the potential to disentangle the contributions of genetic versus family environmental factors in the familiar transmission of coronary heart disease (CHD) because adoptees do not share the same family environment as their biological parents. The aims of this study were as follows: (1) to examine the risk of CHD in adopted men and women with at least one biological parent with CHD and (2) to examine the risk of CHD in adopted men and women with at least one adoptive parent with CHD.
METHODS:
The Swedish Multigenerational register was used to follow all Swedish-born adoptees (born in or after 1932, n = 80,214) between January 1, 1973, and December 31, 2008, for CHD.... (More) - BACKGROUND:
Studies of adoptees have the potential to disentangle the contributions of genetic versus family environmental factors in the familiar transmission of coronary heart disease (CHD) because adoptees do not share the same family environment as their biological parents. The aims of this study were as follows: (1) to examine the risk of CHD in adopted men and women with at least one biological parent with CHD and (2) to examine the risk of CHD in adopted men and women with at least one adoptive parent with CHD.
METHODS:
The Swedish Multigenerational register was used to follow all Swedish-born adoptees (born in or after 1932, n = 80,214) between January 1, 1973, and December 31, 2008, for CHD. The risk of CHD was estimated in adopted men and women with at least one biological parent with CHD and adopted men and women with at least one adoptive parent with CHD. The control groups consisted of adopted men or women without a biological parent with CHD or adopted men or women without an adoptive parent with CHD.
RESULTS:
Adopted men and women with at least one biological parent with CHD (n = 749) were 1.4 to 1.6 times (statistically significant, 95% CI) more likely to have CHD than adoptees without a biological parent with CHD. In contrast, men and women with at least one adoptive parent with CHD (n = 1,009) were not at increased risk of the disease.
CONCLUSIONS:
These findings (based on validated hospital diagnoses unbiased by recall) suggest that the familiar transmission of CHD from parents to offspring is more related to genetic factors than to family environmental factors. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2151168
- author
- Sundquist, Kristina
LU
; Winkleby, Marilyn
LU
; Li, Xinjun
LU
; Ji, Jianguang
LU
; Hemminki, Kari
LU
and Sundquist, Jan
LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- American Heart Journal
- volume
- 162
- issue
- 2
- pages
- 317 - 323
- publisher
- Mosby-Elsevier
- external identifiers
-
- wos:000293729400015
- pmid:21835293
- scopus:80051672006
- ISSN
- 1097-6744
- DOI
- 10.1016/j.ahj.2011.05.013
- language
- English
- LU publication?
- yes
- id
- 4de2a9db-cbca-42d9-8bd6-5165f8f5b69a (old id 2151168)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21835293?dopt=Abstract
- date added to LUP
- 2016-04-01 10:40:14
- date last changed
- 2022-02-17 20:10:38
@article{4de2a9db-cbca-42d9-8bd6-5165f8f5b69a,
abstract = {{BACKGROUND:<br/><br>
Studies of adoptees have the potential to disentangle the contributions of genetic versus family environmental factors in the familiar transmission of coronary heart disease (CHD) because adoptees do not share the same family environment as their biological parents. The aims of this study were as follows: (1) to examine the risk of CHD in adopted men and women with at least one biological parent with CHD and (2) to examine the risk of CHD in adopted men and women with at least one adoptive parent with CHD.<br/><br>
<br/><br>
METHODS:<br/><br>
The Swedish Multigenerational register was used to follow all Swedish-born adoptees (born in or after 1932, n = 80,214) between January 1, 1973, and December 31, 2008, for CHD. The risk of CHD was estimated in adopted men and women with at least one biological parent with CHD and adopted men and women with at least one adoptive parent with CHD. The control groups consisted of adopted men or women without a biological parent with CHD or adopted men or women without an adoptive parent with CHD.<br/><br>
<br/><br>
RESULTS:<br/><br>
Adopted men and women with at least one biological parent with CHD (n = 749) were 1.4 to 1.6 times (statistically significant, 95% CI) more likely to have CHD than adoptees without a biological parent with CHD. In contrast, men and women with at least one adoptive parent with CHD (n = 1,009) were not at increased risk of the disease.<br/><br>
<br/><br>
CONCLUSIONS:<br/><br>
These findings (based on validated hospital diagnoses unbiased by recall) suggest that the familiar transmission of CHD from parents to offspring is more related to genetic factors than to family environmental factors.}},
author = {{Sundquist, Kristina and Winkleby, Marilyn and Li, Xinjun and Ji, Jianguang and Hemminki, Kari and Sundquist, Jan}},
issn = {{1097-6744}},
language = {{eng}},
number = {{2}},
pages = {{317--323}},
publisher = {{Mosby-Elsevier}},
series = {{American Heart Journal}},
title = {{Familial [corrected] transmission of coronary heart disease: a cohort study of 80,214 Swedish adoptees linked to their biological and adoptive parents.}},
url = {{https://lup.lub.lu.se/search/files/2042203/2295320.pdf}},
doi = {{10.1016/j.ahj.2011.05.013}},
volume = {{162}},
year = {{2011}},
}