Ophthalmic manifestations in children with tuberous sclerosis complex
Öhnell, Hanna Maria LU ; Kjellström, Ulrika LU ; Eklund, Erik ; Pearsson, Kevin LU
; Bekassy, Zivile
LU
and Gränse, Lotta
LU
(2023)
In Acta Ophthalmologica
- Abstract
Purpose: To report on the ophthalmic findings in children with tuberous sclerosis complex (TSC) in southern Sweden, and to investigate the frequency of refractive errors, strabismus and cerebral visual impairment associated with this condition. Methods: This was a retrospective cohort study including all paediatric patients with TSC in southern Sweden born between 1983 and 2020. Medical records were reviewed regarding retinal findings, visual acuity, refractive error, strabismus, full-field electroretinography results and cerebral visual impairment. Results: Ophthalmological records were available for 50 of the 52 children in the region diagnosed with TSC. The mean age at the last visit was 12.4 (SD 7.2) years. Monocular visual acuity... (More)
Purpose: To report on the ophthalmic findings in children with tuberous sclerosis complex (TSC) in southern Sweden, and to investigate the frequency of refractive errors, strabismus and cerebral visual impairment associated with this condition. Methods: This was a retrospective cohort study including all paediatric patients with TSC in southern Sweden born between 1983 and 2020. Medical records were reviewed regarding retinal findings, visual acuity, refractive error, strabismus, full-field electroretinography results and cerebral visual impairment. Results: Ophthalmological records were available for 50 of the 52 children in the region diagnosed with TSC. The mean age at the last visit was 12.4 (SD 7.2) years. Monocular visual acuity had been measured in 38 patients, and the median value did not deviate from that expected for their age in the better eye, but by −0.2 Snellen decimal acuity in the worse eye. Refractive errors were found in 62% of the patients, and strabismus in 16%. Retinal astrocytic hamartomas were found in 34% and achromatic patches in 34%. Ten of the patients on medication with vigabatrin were examined with full-field electroretinography and treatment had to be stopped or lowered in three (30%), due to a reduced response. Investigation of cerebral visual impairment had not been conducted in any of the children. Conclusion: Refractive errors and strabismus were common among children with TSC. None of the patients in this cohort had undergone investigation for cerebral visual impairment. The general awareness of cerebral visual impairment among ophthalmologists is poor and constitutes an important area for improvement.
(Less)
- author
- Öhnell, Hanna Maria
LU
; Kjellström, Ulrika
LU
; Eklund, Erik
; Pearsson, Kevin
LU
; Bekassy, Zivile
LU
and Gränse, Lotta
LU
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- epub
- subject
- keywords
- achromatic patches, cerebral visual impairment, ophthalmic findings, refractive errors, retinal hamartomas, tuberous sclerosis complex, visual acuity
- in
- Acta Ophthalmologica
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:37991117
- scopus:85177587043
- ISSN
- 1755-375X
- DOI
- 10.1111/aos.15812
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © 2023 The Authors. Acta Ophthalmologica published by John Wiley & Sons Ltd on behalf of Acta Ophthalmologica Scandinavica Foundation.
- id
- 4de721fc-1c52-4b91-9ec6-aa9ce8d35767
- date added to LUP
- 2024-01-08 12:57:16
- date last changed
- 2024-04-23 08:33:27
@article{4de721fc-1c52-4b91-9ec6-aa9ce8d35767,
abstract = {{<p>Purpose: To report on the ophthalmic findings in children with tuberous sclerosis complex (TSC) in southern Sweden, and to investigate the frequency of refractive errors, strabismus and cerebral visual impairment associated with this condition. Methods: This was a retrospective cohort study including all paediatric patients with TSC in southern Sweden born between 1983 and 2020. Medical records were reviewed regarding retinal findings, visual acuity, refractive error, strabismus, full-field electroretinography results and cerebral visual impairment. Results: Ophthalmological records were available for 50 of the 52 children in the region diagnosed with TSC. The mean age at the last visit was 12.4 (SD 7.2) years. Monocular visual acuity had been measured in 38 patients, and the median value did not deviate from that expected for their age in the better eye, but by −0.2 Snellen decimal acuity in the worse eye. Refractive errors were found in 62% of the patients, and strabismus in 16%. Retinal astrocytic hamartomas were found in 34% and achromatic patches in 34%. Ten of the patients on medication with vigabatrin were examined with full-field electroretinography and treatment had to be stopped or lowered in three (30%), due to a reduced response. Investigation of cerebral visual impairment had not been conducted in any of the children. Conclusion: Refractive errors and strabismus were common among children with TSC. None of the patients in this cohort had undergone investigation for cerebral visual impairment. The general awareness of cerebral visual impairment among ophthalmologists is poor and constitutes an important area for improvement.</p>}},
author = {{Öhnell, Hanna Maria and Kjellström, Ulrika and Eklund, Erik and Pearsson, Kevin and Bekassy, Zivile and Gränse, Lotta}},
issn = {{1755-375X}},
keywords = {{achromatic patches; cerebral visual impairment; ophthalmic findings; refractive errors; retinal hamartomas; tuberous sclerosis complex; visual acuity}},
language = {{eng}},
publisher = {{Wiley-Blackwell}},
series = {{Acta Ophthalmologica}},
title = {{Ophthalmic manifestations in children with tuberous sclerosis complex}},
url = {{http://dx.doi.org/10.1111/aos.15812}},
doi = {{10.1111/aos.15812}},
year = {{2023}},
}