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Prediagnostic intake of dairy products and dietary calcium and colorectal cancer survival - results from the EPIC cohort study.

Dik, Vincent K ; Murphy, Neil ; Siersema, Peter D ; Fedirko, Veronika ; Jenab, Mazda ; Kong, So Y ; Hansen, Camilla P ; Overvad, Kim ; Tjonneland, Anne and Olsen, Anja , et al. (2014) In Cancer Epidemiology Biomarkers & Prevention 23(9). p.1813-1823
Abstract
Background We investigated whether prediagnostic reported intake of dairy products and dietary calcium are associated with colorectal cancer (CRC) survival. Methods Data from 3,859 subjects with CRC (42.1% male, mean age at diagnosis 64.2 ± 8.1 years) in the European Investigation into Cancer and Nutrition (EPIC) cohort were analyzed. Intake of dairy products and dietary calcium was assessed at baseline (1992-2000) using validated, country-specific dietary questionnaires. Multivariable Cox regression models were used to calculate hazard ratios (HR) and corresponding 95% confidence intervals (95%-CI) for CRC specific death (n=1,028) and all-cause death (n=1,525) for different quartiles of intake. Results The consumption of total dairy... (More)
Background We investigated whether prediagnostic reported intake of dairy products and dietary calcium are associated with colorectal cancer (CRC) survival. Methods Data from 3,859 subjects with CRC (42.1% male, mean age at diagnosis 64.2 ± 8.1 years) in the European Investigation into Cancer and Nutrition (EPIC) cohort were analyzed. Intake of dairy products and dietary calcium was assessed at baseline (1992-2000) using validated, country-specific dietary questionnaires. Multivariable Cox regression models were used to calculate hazard ratios (HR) and corresponding 95% confidence intervals (95%-CI) for CRC specific death (n=1,028) and all-cause death (n=1,525) for different quartiles of intake. Results The consumption of total dairy products was not statistically significantly associated with risk of CRC-specific death (adjusted HR Q4 vs. Q1: 1.17 95%-CI 0.97-1.43) nor of all-cause death (Q4 vs. Q1: 1.16 95%-CI 0.98-1.36). Multivariable adjusted HRs for CRC-specific death (Q4 vs. Q1) were 1.21 (95%-CI 0.99-1.48) for milk, 1.09 (95%-CI 0.88-1.34) for yoghurt and 0.93 (95%-CI 0.76-1.14) for cheese. The intake of dietary calcium was not associated with the risk of CRC-specific (adjusted HR Q4 vs. Q1: 1.01 95%-CI 0.81-1.26) nor of all-cause death (Q4 vs. Q1: 1.01 95%-CI 0.84-1.21). Conclusions The prediagnostic reported intake of dairy products and dietary calcium are not associated with disease-specific or all-cause risk of death in patients diagnosed with CRC. Impact The impact of diet on cancer survival is largely unknown. This study shows that despite it's inverse association with CRC risk, the prediagnostic intake of dairy and dietary calcium do not affect CRC survival. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cancer Epidemiology Biomarkers & Prevention
volume
23
issue
9
pages
1813 - 1823
publisher
American Association for Cancer Research
external identifiers
  • pmid:24917183
  • wos:000345276100010
  • scopus:84907174391
  • pmid:24917183
ISSN
1538-7755
DOI
10.1158/1055-9965.EPI-14-0172
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Surgery Research Unit (013242220), Pathology, (Lund) (013030000)
id
4f447070-45b4-40dd-82c7-b29c9279763d (old id 4528841)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24917183?dopt=Abstract
date added to LUP
2016-04-01 10:32:50
date last changed
2024-01-12 12:22:02
@article{4f447070-45b4-40dd-82c7-b29c9279763d,
  abstract     = {{Background We investigated whether prediagnostic reported intake of dairy products and dietary calcium are associated with colorectal cancer (CRC) survival. Methods Data from 3,859 subjects with CRC (42.1% male, mean age at diagnosis 64.2 ± 8.1 years) in the European Investigation into Cancer and Nutrition (EPIC) cohort were analyzed. Intake of dairy products and dietary calcium was assessed at baseline (1992-2000) using validated, country-specific dietary questionnaires. Multivariable Cox regression models were used to calculate hazard ratios (HR) and corresponding 95% confidence intervals (95%-CI) for CRC specific death (n=1,028) and all-cause death (n=1,525) for different quartiles of intake. Results The consumption of total dairy products was not statistically significantly associated with risk of CRC-specific death (adjusted HR Q4 vs. Q1: 1.17 95%-CI 0.97-1.43) nor of all-cause death (Q4 vs. Q1: 1.16 95%-CI 0.98-1.36). Multivariable adjusted HRs for CRC-specific death (Q4 vs. Q1) were 1.21 (95%-CI 0.99-1.48) for milk, 1.09 (95%-CI 0.88-1.34) for yoghurt and 0.93 (95%-CI 0.76-1.14) for cheese. The intake of dietary calcium was not associated with the risk of CRC-specific (adjusted HR Q4 vs. Q1: 1.01 95%-CI 0.81-1.26) nor of all-cause death (Q4 vs. Q1: 1.01 95%-CI 0.84-1.21). Conclusions The prediagnostic reported intake of dairy products and dietary calcium are not associated with disease-specific or all-cause risk of death in patients diagnosed with CRC. Impact The impact of diet on cancer survival is largely unknown. This study shows that despite it's inverse association with CRC risk, the prediagnostic intake of dairy and dietary calcium do not affect CRC survival.}},
  author       = {{Dik, Vincent K and Murphy, Neil and Siersema, Peter D and Fedirko, Veronika and Jenab, Mazda and Kong, So Y and Hansen, Camilla P and Overvad, Kim and Tjonneland, Anne and Olsen, Anja and Dossus, Laure and Racine, Antoine and Bastide, Nadia and Li, Kuanrong and Kühn, Tilman and Boeing, Heiner and Aleksandrova, Krasimira and Trichopoulou, Antonia and Trichopoulos, Dimitrios and Barbitsioti, Antonia and Palli, Domenico and Contiero, Paolo and Vineis, Paolo and Tumino, Rosario and Panico, Salvatore and Peeters, Petra H M and Weiderpass, Elisabete and Skeie, Guri and Hjartaker, Anette and Amiano, Pilar and Sanchez, Maria-Jose and Fonseca-Nunes, Ana and Barricarte, Aurelio and Chirlaque, Maria-Dolores and Redondo, Maria-Luisa and Jirström, Karin and Manjer, Jonas and Nilsson, Lena M and Wennberg, Maria and Bradbury, Kathryn E and Khaw, Kay-Tee and Wareham, Nicholas and Cross, Amanda J and Riboli, Elio and Bueno-de-Mesquita, H Bas}},
  issn         = {{1538-7755}},
  language     = {{eng}},
  number       = {{9}},
  pages        = {{1813--1823}},
  publisher    = {{American Association for Cancer Research}},
  series       = {{Cancer Epidemiology Biomarkers & Prevention}},
  title        = {{Prediagnostic intake of dairy products and dietary calcium and colorectal cancer survival - results from the EPIC cohort study.}},
  url          = {{http://dx.doi.org/10.1158/1055-9965.EPI-14-0172}},
  doi          = {{10.1158/1055-9965.EPI-14-0172}},
  volume       = {{23}},
  year         = {{2014}},
}