Advanced

Maternal smoking during pregnancy and offspring type 1 diabetes mellitus risk: accounting for HLA haplotype.

Mattsson, Kristina LU ; Jönsson, Ida LU ; Malmqvist, Ebba LU ; Larsson, Helena LU and Rylander, Lars LU (2015) In European Journal of Epidemiology 30(3). p.231-238
Abstract
The main objective of this study was to investigate the risk of type 1 diabetes mellitus (T1D) in children exposed to tobacco smoking in utero, also taking genetic predisposition as expressed by HLA haplotype into account. In Skåne, the southernmost county of Sweden, all children born 1999-2005 who developed T1D were registered, resulting in 344 cases. For each child with T1D, three control children, matched for HLA haplotype and birthyear, were selected. Information on prenatal smoking exposure was retrieved from a regional birth register. Conditional logistic regressions were used to evaluate T1D risk following prenatal smoking exposure. In these data, maternal smoking in early pregnancy was associated with a higher risk of her child... (More)
The main objective of this study was to investigate the risk of type 1 diabetes mellitus (T1D) in children exposed to tobacco smoking in utero, also taking genetic predisposition as expressed by HLA haplotype into account. In Skåne, the southernmost county of Sweden, all children born 1999-2005 who developed T1D were registered, resulting in 344 cases. For each child with T1D, three control children, matched for HLA haplotype and birthyear, were selected. Information on prenatal smoking exposure was retrieved from a regional birth register. Conditional logistic regressions were used to evaluate T1D risk following prenatal smoking exposure. In these data, maternal smoking in early pregnancy was associated with a higher risk of her child developing T1D [odds ratio (OR) 2.83; 95 % confidence interval (CI) 1.67-4.80 for 1-9 cigarettes/day, and OR 3.91; 95 % CI 1.22-12.51 for >9 cigarettes/day]. Results remained through all adjustments and sensitivity analyses. When genetic predisposition in terms of HLA haplotype was taken into account, we found that children exposed to smoking during fetal life were at higher risk of developing T1D in childhood. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Journal of Epidemiology
volume
30
issue
3
pages
231 - 238
publisher
Springer
external identifiers
  • pmid:25576078
  • wos:000351606300006
  • scopus:84925717478
ISSN
1573-7284
DOI
10.1007/s10654-014-9985-1
language
English
LU publication?
yes
id
4e675a21-36e2-46b6-8642-13f35f183fd5 (old id 5040861)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25576078?dopt=Abstract
date added to LUP
2015-02-02 21:23:59
date last changed
2017-11-12 03:05:16
@article{4e675a21-36e2-46b6-8642-13f35f183fd5,
  abstract     = {The main objective of this study was to investigate the risk of type 1 diabetes mellitus (T1D) in children exposed to tobacco smoking in utero, also taking genetic predisposition as expressed by HLA haplotype into account. In Skåne, the southernmost county of Sweden, all children born 1999-2005 who developed T1D were registered, resulting in 344 cases. For each child with T1D, three control children, matched for HLA haplotype and birthyear, were selected. Information on prenatal smoking exposure was retrieved from a regional birth register. Conditional logistic regressions were used to evaluate T1D risk following prenatal smoking exposure. In these data, maternal smoking in early pregnancy was associated with a higher risk of her child developing T1D [odds ratio (OR) 2.83; 95 % confidence interval (CI) 1.67-4.80 for 1-9 cigarettes/day, and OR 3.91; 95 % CI 1.22-12.51 for >9 cigarettes/day]. Results remained through all adjustments and sensitivity analyses. When genetic predisposition in terms of HLA haplotype was taken into account, we found that children exposed to smoking during fetal life were at higher risk of developing T1D in childhood.},
  author       = {Mattsson, Kristina and Jönsson, Ida and Malmqvist, Ebba and Larsson, Helena and Rylander, Lars},
  issn         = {1573-7284},
  language     = {eng},
  number       = {3},
  pages        = {231--238},
  publisher    = {Springer},
  series       = {European Journal of Epidemiology},
  title        = {Maternal smoking during pregnancy and offspring type 1 diabetes mellitus risk: accounting for HLA haplotype.},
  url          = {http://dx.doi.org/10.1007/s10654-014-9985-1},
  volume       = {30},
  year         = {2015},
}