Failure of bone induction by bone matrix in adult monkeys
Aspenberg, P. LU ; Lohmander, Stefan LU
and Thorngren, K. G.
LU
(1988)
In Journal of Bone and Joint Surgery: British Volume
70(4).
p.625-627
- Abstract
Extraskeletal bone formation can be induced in rodents by implantation of demineralised bone matrix and such implantation has been used to treat bone defects in man, but it is uncertain if induction or merely conduction occurs. We studied bone induction in primates by excising segments of the fibulae of adult squirrel monkeys, defatting and demineralising them before reimplanting them into the quadriceps of the same animal. As a control experiment, rat matrix was prepared in exactly the same way and implanted in rats. After six weeks the implants were harvested and either ashed and analysed for calcium content or prepared for histology. In the rats, the calcium content indicated that about 20% of the original matrix had been replaced by... (More)
Extraskeletal bone formation can be induced in rodents by implantation of demineralised bone matrix and such implantation has been used to treat bone defects in man, but it is uncertain if induction or merely conduction occurs. We studied bone induction in primates by excising segments of the fibulae of adult squirrel monkeys, defatting and demineralising them before reimplanting them into the quadriceps of the same animal. As a control experiment, rat matrix was prepared in exactly the same way and implanted in rats. After six weeks the implants were harvested and either ashed and analysed for calcium content or prepared for histology. In the rats, the calcium content indicated that about 20% of the original matrix had been replaced by new bone. In the monkeys the calcium content was about the same as that in normal body fluid and no bone was seen in histological sections. This result casts doubt on the use of demineralised human bone matrix as a bone inductor, although it may function by other mechanisms.
(Less)
- author
- Aspenberg, P.
LU
; Lohmander, Stefan
LU
and Thorngren, K. G.
LU
- organization
- publishing date
- 1988
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- animals, bone formation, bone matrix
- in
- Journal of Bone and Joint Surgery: British Volume
- volume
- 70
- issue
- 4
- pages
- 3 pages
- publisher
- British Editorial Society of Bone & Joint Surgery
- external identifiers
-
- scopus:0023809044
- pmid:3403612
- ISSN
- 0301-620X
- language
- English
- LU publication?
- yes
- id
- 5050803f-664a-454a-bc95-0ef28e04ce18
- date added to LUP
- 2016-05-04 13:06:55
- date last changed
- 2024-01-04 02:43:04
@article{5050803f-664a-454a-bc95-0ef28e04ce18,
abstract = {{<p>Extraskeletal bone formation can be induced in rodents by implantation of demineralised bone matrix and such implantation has been used to treat bone defects in man, but it is uncertain if induction or merely conduction occurs. We studied bone induction in primates by excising segments of the fibulae of adult squirrel monkeys, defatting and demineralising them before reimplanting them into the quadriceps of the same animal. As a control experiment, rat matrix was prepared in exactly the same way and implanted in rats. After six weeks the implants were harvested and either ashed and analysed for calcium content or prepared for histology. In the rats, the calcium content indicated that about 20% of the original matrix had been replaced by new bone. In the monkeys the calcium content was about the same as that in normal body fluid and no bone was seen in histological sections. This result casts doubt on the use of demineralised human bone matrix as a bone inductor, although it may function by other mechanisms.</p>}},
author = {{Aspenberg, P. and Lohmander, Stefan and Thorngren, K. G.}},
issn = {{0301-620X}},
keywords = {{animals; bone formation; bone matrix}},
language = {{eng}},
number = {{4}},
pages = {{625--627}},
publisher = {{British Editorial Society of Bone & Joint Surgery}},
series = {{Journal of Bone and Joint Surgery: British Volume}},
title = {{Failure of bone induction by bone matrix in adult monkeys}},
volume = {{70}},
year = {{1988}},
}