Non-genetic risk factors and their influence on the management of patients in the clinic
(2015) In European Journal of Haematology 94. p.2-6- Abstract
- The development of inhibitors is the most serious iatrogenic complication affecting patients with haemophilia. This complication is associated with impaired vital or functional prognosis, reduced quality of life and increased cost of treatment. The reasons why some patients develop antibodies to factor replacement and others do not remain unclear. It is however clear that inhibitor development results from a complex multifactorial interaction between genetic and non-genetic risk factors. Environmental influences implicated in increasing the risk of inhibitor formation can be viewed as modifiable risk factors. Therefore, identification of the non-genetic risk factors may offer the possibility of personalising haemophilia therapy by... (More)
- The development of inhibitors is the most serious iatrogenic complication affecting patients with haemophilia. This complication is associated with impaired vital or functional prognosis, reduced quality of life and increased cost of treatment. The reasons why some patients develop antibodies to factor replacement and others do not remain unclear. It is however clear that inhibitor development results from a complex multifactorial interaction between genetic and non-genetic risk factors. Environmental influences implicated in increasing the risk of inhibitor formation can be viewed as modifiable risk factors. Therefore, identification of the non-genetic risk factors may offer the possibility of personalising haemophilia therapy by modifying treatment strategies in high-risk patients in the critical early phase of factor VIII exposure. In this article, we review the non-genetic factors reported as well as the potential impact of danger signals and the different scores for inhibitor development risk stratification. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/5075981
- author
- Alvarez, Teresa ; Soto, Immaculada and Astermark, Jan LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- haemophilia, inhibitors, risk factors, environmental influences
- in
- European Journal of Haematology
- volume
- 94
- pages
- 2 - 6
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000347371100002
- scopus:84920271407
- pmid:25560787
- ISSN
- 1600-0609
- DOI
- 10.1111/ejh.12494
- language
- English
- LU publication?
- yes
- id
- f6486c01-2b8a-425f-936f-d07f287e8aff (old id 5075981)
- date added to LUP
- 2016-04-01 09:53:24
- date last changed
- 2022-02-02 03:49:12
@article{f6486c01-2b8a-425f-936f-d07f287e8aff,
abstract = {{The development of inhibitors is the most serious iatrogenic complication affecting patients with haemophilia. This complication is associated with impaired vital or functional prognosis, reduced quality of life and increased cost of treatment. The reasons why some patients develop antibodies to factor replacement and others do not remain unclear. It is however clear that inhibitor development results from a complex multifactorial interaction between genetic and non-genetic risk factors. Environmental influences implicated in increasing the risk of inhibitor formation can be viewed as modifiable risk factors. Therefore, identification of the non-genetic risk factors may offer the possibility of personalising haemophilia therapy by modifying treatment strategies in high-risk patients in the critical early phase of factor VIII exposure. In this article, we review the non-genetic factors reported as well as the potential impact of danger signals and the different scores for inhibitor development risk stratification.}},
author = {{Alvarez, Teresa and Soto, Immaculada and Astermark, Jan}},
issn = {{1600-0609}},
keywords = {{haemophilia; inhibitors; risk factors; environmental influences}},
language = {{eng}},
pages = {{2--6}},
publisher = {{Wiley-Blackwell}},
series = {{European Journal of Haematology}},
title = {{Non-genetic risk factors and their influence on the management of patients in the clinic}},
url = {{http://dx.doi.org/10.1111/ejh.12494}},
doi = {{10.1111/ejh.12494}},
volume = {{94}},
year = {{2015}},
}