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Non-genetic risk factors and their influence on the management of patients in the clinic

Alvarez, Teresa; Soto, Immaculada and Astermark, Jan LU (2015) In European Journal of Haematology 94. p.2-6
Abstract
The development of inhibitors is the most serious iatrogenic complication affecting patients with haemophilia. This complication is associated with impaired vital or functional prognosis, reduced quality of life and increased cost of treatment. The reasons why some patients develop antibodies to factor replacement and others do not remain unclear. It is however clear that inhibitor development results from a complex multifactorial interaction between genetic and non-genetic risk factors. Environmental influences implicated in increasing the risk of inhibitor formation can be viewed as modifiable risk factors. Therefore, identification of the non-genetic risk factors may offer the possibility of personalising haemophilia therapy by... (More)
The development of inhibitors is the most serious iatrogenic complication affecting patients with haemophilia. This complication is associated with impaired vital or functional prognosis, reduced quality of life and increased cost of treatment. The reasons why some patients develop antibodies to factor replacement and others do not remain unclear. It is however clear that inhibitor development results from a complex multifactorial interaction between genetic and non-genetic risk factors. Environmental influences implicated in increasing the risk of inhibitor formation can be viewed as modifiable risk factors. Therefore, identification of the non-genetic risk factors may offer the possibility of personalising haemophilia therapy by modifying treatment strategies in high-risk patients in the critical early phase of factor VIII exposure. In this article, we review the non-genetic factors reported as well as the potential impact of danger signals and the different scores for inhibitor development risk stratification. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
haemophilia, inhibitors, risk factors, environmental influences
in
European Journal of Haematology
volume
94
pages
2 - 6
publisher
Wiley-Blackwell
external identifiers
  • wos:000347371100002
  • scopus:84920271407
ISSN
1600-0609
DOI
10.1111/ejh.12494
language
English
LU publication?
yes
id
f6486c01-2b8a-425f-936f-d07f287e8aff (old id 5075981)
date added to LUP
2015-03-02 07:07:51
date last changed
2017-01-01 03:05:22
@article{f6486c01-2b8a-425f-936f-d07f287e8aff,
  abstract     = {The development of inhibitors is the most serious iatrogenic complication affecting patients with haemophilia. This complication is associated with impaired vital or functional prognosis, reduced quality of life and increased cost of treatment. The reasons why some patients develop antibodies to factor replacement and others do not remain unclear. It is however clear that inhibitor development results from a complex multifactorial interaction between genetic and non-genetic risk factors. Environmental influences implicated in increasing the risk of inhibitor formation can be viewed as modifiable risk factors. Therefore, identification of the non-genetic risk factors may offer the possibility of personalising haemophilia therapy by modifying treatment strategies in high-risk patients in the critical early phase of factor VIII exposure. In this article, we review the non-genetic factors reported as well as the potential impact of danger signals and the different scores for inhibitor development risk stratification.},
  author       = {Alvarez, Teresa and Soto, Immaculada and Astermark, Jan},
  issn         = {1600-0609},
  keyword      = {haemophilia,inhibitors,risk factors,environmental influences},
  language     = {eng},
  pages        = {2--6},
  publisher    = {Wiley-Blackwell},
  series       = {European Journal of Haematology},
  title        = {Non-genetic risk factors and their influence on the management of patients in the clinic},
  url          = {http://dx.doi.org/10.1111/ejh.12494},
  volume       = {94},
  year         = {2015},
}