Advanced

The ageing patient with haemophilia

Canaro, Mariana; Goranova-Marinova, Veselina and Berntorp, Erik LU (2015) In European Journal of Haematology 94. p.17-22
Abstract
Older patients with haemophilia (PWH) face many challenges related not only to haemophilia but also to general comorbidities associated with ageing. This article discusses the clinical experience published about the high prevalence of diseases in older PWH. These conditions are managed in the general population by healthcare workers with little training in haemophilia. Haemophilic arthropathy is common in elderly PWH. Prophylaxis starting at an early age in sufficient dose regimens to prevent arthropathy did not occur in patients who are now older than around 40yr. Many PWH above this age thus have limitations in their activities of daily life. Cardiovascular diseases have become increasingly common in the growing, ageing cohort of PWH.... (More)
Older patients with haemophilia (PWH) face many challenges related not only to haemophilia but also to general comorbidities associated with ageing. This article discusses the clinical experience published about the high prevalence of diseases in older PWH. These conditions are managed in the general population by healthcare workers with little training in haemophilia. Haemophilic arthropathy is common in elderly PWH. Prophylaxis starting at an early age in sufficient dose regimens to prevent arthropathy did not occur in patients who are now older than around 40yr. Many PWH above this age thus have limitations in their activities of daily life. Cardiovascular diseases have become increasingly common in the growing, ageing cohort of PWH. Lifestyle issues such as sexual dysfunction may be exacerbated by the medical issues and psychological problems associated with haemophilia. Hepatitis C virus is a leading problem in PWH. Coinfection with HIV accelerates the progression to end-stage liver disease. Acute and chronic renal failure is more common in adult PWH than in general population. Other comorbidities are reviewed. The evidence is scarce, so it is imperative to report any experience regarding the diagnosis and treatment of these entities, to improve the quality of life of older PWH. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
haemophilia, ageing, comorbidities, arthropathy, cardiovascular disease, lifestyle issues
in
European Journal of Haematology
volume
94
pages
17 - 22
publisher
Wiley-Blackwell
external identifiers
  • wos:000347371100005
  • scopus:84920274246
ISSN
1600-0609
DOI
10.1111/ejh.12497
language
English
LU publication?
yes
id
2049c399-4d09-4fca-b04f-f3bfdc309d6f (old id 5075995)
date added to LUP
2015-03-02 07:08:13
date last changed
2017-11-12 03:16:02
@article{2049c399-4d09-4fca-b04f-f3bfdc309d6f,
  abstract     = {Older patients with haemophilia (PWH) face many challenges related not only to haemophilia but also to general comorbidities associated with ageing. This article discusses the clinical experience published about the high prevalence of diseases in older PWH. These conditions are managed in the general population by healthcare workers with little training in haemophilia. Haemophilic arthropathy is common in elderly PWH. Prophylaxis starting at an early age in sufficient dose regimens to prevent arthropathy did not occur in patients who are now older than around 40yr. Many PWH above this age thus have limitations in their activities of daily life. Cardiovascular diseases have become increasingly common in the growing, ageing cohort of PWH. Lifestyle issues such as sexual dysfunction may be exacerbated by the medical issues and psychological problems associated with haemophilia. Hepatitis C virus is a leading problem in PWH. Coinfection with HIV accelerates the progression to end-stage liver disease. Acute and chronic renal failure is more common in adult PWH than in general population. Other comorbidities are reviewed. The evidence is scarce, so it is imperative to report any experience regarding the diagnosis and treatment of these entities, to improve the quality of life of older PWH.},
  author       = {Canaro, Mariana and Goranova-Marinova, Veselina and Berntorp, Erik},
  issn         = {1600-0609},
  keyword      = {haemophilia,ageing,comorbidities,arthropathy,cardiovascular disease,lifestyle issues},
  language     = {eng},
  pages        = {17--22},
  publisher    = {Wiley-Blackwell},
  series       = {European Journal of Haematology},
  title        = {The ageing patient with haemophilia},
  url          = {http://dx.doi.org/10.1111/ejh.12497},
  volume       = {94},
  year         = {2015},
}