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Theoretical considerations for understanding a Purkinje cell timing mechanism

Johansson, Fredrik LU and Hesslow, Germund LU (2014) In Communicative & Integrative Biology 7(6). p.994376-994376
Abstract
In classical conditioning, cerebellar Purkinje cells learn an adaptively timed pause in spontaneous firing. This pause reaches its maximum near the end of the interstimulus interval. While it was thought that this timing was due to temporal patterns in the input signal and selective engagement of changes in synapse strength, we have shown Purkinje cells learn timed responses even when the conditional stimulus is delivered to its immediate afferents.(1) This shows that Purkinje cells have a cellular timing mechanism. The cellular models of intrinsic timing we are aware of are based on adapting the rise time of the concentration of a given ion. As an alternative, we here propose a selection mechanism in abstract terms for how a Purkinje cell... (More)
In classical conditioning, cerebellar Purkinje cells learn an adaptively timed pause in spontaneous firing. This pause reaches its maximum near the end of the interstimulus interval. While it was thought that this timing was due to temporal patterns in the input signal and selective engagement of changes in synapse strength, we have shown Purkinje cells learn timed responses even when the conditional stimulus is delivered to its immediate afferents.(1) This shows that Purkinje cells have a cellular timing mechanism. The cellular models of intrinsic timing we are aware of are based on adapting the rise time of the concentration of a given ion. As an alternative, we here propose a selection mechanism in abstract terms for how a Purkinje cell could learn to respond at a particular time after an external trigger. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Communicative & Integrative Biology
volume
7
issue
6
pages
994376 - 994376
publisher
Landes Bioscience
external identifiers
  • pmid:26479712
  • scopus:84922962665
ISSN
1942-0889
DOI
10.4161/19420889.2014.994376
project
Cognition, Communication and Learning
language
English
LU publication?
yes
id
5081507a-cec1-4f34-b239-ba84389f5890 (old id 4698371)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26479712?dopt=Abstract
date added to LUP
2015-02-22 09:58:49
date last changed
2017-06-25 04:10:38
@article{5081507a-cec1-4f34-b239-ba84389f5890,
  abstract     = {In classical conditioning, cerebellar Purkinje cells learn an adaptively timed pause in spontaneous firing. This pause reaches its maximum near the end of the interstimulus interval. While it was thought that this timing was due to temporal patterns in the input signal and selective engagement of changes in synapse strength, we have shown Purkinje cells learn timed responses even when the conditional stimulus is delivered to its immediate afferents.(1) This shows that Purkinje cells have a cellular timing mechanism. The cellular models of intrinsic timing we are aware of are based on adapting the rise time of the concentration of a given ion. As an alternative, we here propose a selection mechanism in abstract terms for how a Purkinje cell could learn to respond at a particular time after an external trigger.},
  author       = {Johansson, Fredrik and Hesslow, Germund},
  issn         = {1942-0889},
  language     = {eng},
  number       = {6},
  pages        = {994376--994376},
  publisher    = {Landes Bioscience},
  series       = {Communicative & Integrative Biology},
  title        = {Theoretical considerations for understanding a Purkinje cell timing mechanism},
  url          = {http://dx.doi.org/10.4161/19420889.2014.994376},
  volume       = {7},
  year         = {2014},
}