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FVIII inhibitors: pathogenesis and avoidance.

Astermark, Jan LU (2015) In Blood 125(13). p.2045-2051
Abstract
The pathogenesis of inhibitory antibodies has been the focus of major scientific interest over the last decades and several studies on underlying immune mechanisms and risk factors for formation of these antibodies have been performed with the aim of improving the ability to both predict and prevent their appearance. It seems clear that the decisive factors for the immune response to the deficient factor are multiple and involve components of both a constitutional and therapy-related nature. A scientific concern and obstacle for research in the area of hemophilia is the relatively small cohorts available for studies and the resulting risk of confounded and biased results. Careful interpretation of data is recommended in order to avoid... (More)
The pathogenesis of inhibitory antibodies has been the focus of major scientific interest over the last decades and several studies on underlying immune mechanisms and risk factors for formation of these antibodies have been performed with the aim of improving the ability to both predict and prevent their appearance. It seems clear that the decisive factors for the immune response to the deficient factor are multiple and involve components of both a constitutional and therapy-related nature. A scientific concern and obstacle for research in the area of hemophilia is the relatively small cohorts available for studies and the resulting risk of confounded and biased results. Careful interpretation of data is recommended in order to avoid treatment decisions based on a weak scientific platform. This review will summarize current concepts of the underlying immunological mechanisms and risk factors for development of inhibitory antibodies in patients with hemophilia A, and discuss how these findings may be interpreted and influence our clinical management of patients. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Blood
volume
125
issue
13
pages
2045 - 2051
publisher
American Society of Hematology
external identifiers
  • pmid:25712994
  • wos:000354626300009
  • scopus:84926155035
ISSN
1528-0020
DOI
10.1182/blood-2014-08-535328
language
English
LU publication?
yes
id
c6fcfc8e-3bce-4548-ad82-6294ed329a98 (old id 5142853)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25712994?dopt=Abstract
date added to LUP
2015-03-12 12:22:10
date last changed
2017-09-17 03:39:56
@article{c6fcfc8e-3bce-4548-ad82-6294ed329a98,
  abstract     = {The pathogenesis of inhibitory antibodies has been the focus of major scientific interest over the last decades and several studies on underlying immune mechanisms and risk factors for formation of these antibodies have been performed with the aim of improving the ability to both predict and prevent their appearance. It seems clear that the decisive factors for the immune response to the deficient factor are multiple and involve components of both a constitutional and therapy-related nature. A scientific concern and obstacle for research in the area of hemophilia is the relatively small cohorts available for studies and the resulting risk of confounded and biased results. Careful interpretation of data is recommended in order to avoid treatment decisions based on a weak scientific platform. This review will summarize current concepts of the underlying immunological mechanisms and risk factors for development of inhibitory antibodies in patients with hemophilia A, and discuss how these findings may be interpreted and influence our clinical management of patients.},
  author       = {Astermark, Jan},
  issn         = {1528-0020},
  language     = {eng},
  number       = {13},
  pages        = {2045--2051},
  publisher    = {American Society of Hematology},
  series       = {Blood},
  title        = {FVIII inhibitors: pathogenesis and avoidance.},
  url          = {http://dx.doi.org/10.1182/blood-2014-08-535328},
  volume       = {125},
  year         = {2015},
}