Advanced

Investigation of Dietary Factors and Endometrial Cancer Risk Using a Nutrient-wide Association Study Approach in the EPIC and Nurses' Health Study (NHS) and NHSII.

Merritt, Melissa A; Tzoulaki, Ioanna; Tworoger, Shelley S; De Vivo, Immaculata; Hankinson, Susan E; Fernandes, Judy; Tsilidis, Konstantinos K; Weiderpass, Elisabete; Tjønneland, Anne and Petersen, Kristina E N, et al. (2015) In Cancer Epidemiology Biomarkers & Prevention 24(2). p.466-471
Abstract
Data on the role of dietary factors in endometrial cancer development are limited and inconsistent. We applied a "nutrient-wide association study" approach to systematically evaluate dietary risk associations for endometrial cancer while controlling for multiple hypothesis tests using the false discovery rate (FDR) and validating the results in an independent cohort. We evaluated endometrial cancer risk associations for dietary intake of 84 foods and nutrients based on dietary questionnaires in three prospective studies, the European Prospective Investigation into Cancer and Nutrition (EPIC; N = 1,303 cases) followed by validation of nine foods/nutrients (FDR ≤ 0.10) in the Nurses' Health Studies (NHS/NHSII; N = 1,531 cases). Cox... (More)
Data on the role of dietary factors in endometrial cancer development are limited and inconsistent. We applied a "nutrient-wide association study" approach to systematically evaluate dietary risk associations for endometrial cancer while controlling for multiple hypothesis tests using the false discovery rate (FDR) and validating the results in an independent cohort. We evaluated endometrial cancer risk associations for dietary intake of 84 foods and nutrients based on dietary questionnaires in three prospective studies, the European Prospective Investigation into Cancer and Nutrition (EPIC; N = 1,303 cases) followed by validation of nine foods/nutrients (FDR ≤ 0.10) in the Nurses' Health Studies (NHS/NHSII; N = 1,531 cases). Cox regression models were used to estimate HRs and 95% confidence intervals (CI). In multivariate adjusted comparisons of the extreme categories of intake at baseline, coffee was inversely associated with endometrial cancer risk (EPIC, median intake 750 g/day vs. 8.6; HR, 0.81; 95% CI, 0.68-0.97, Ptrend = 0.09; NHS/NHSII, median intake 1067 g/day vs. none; HR, 0.82; 95% CI, 0.70-0.96, Ptrend = 0.04). Eight other dietary factors that were associated with endometrial cancer risk in the EPIC study (total fat, monounsaturated fat, carbohydrates, phosphorus, butter, yogurt, cheese, and potatoes) were not confirmed in the NHS/NHSII. Our findings suggest that coffee intake may be inversely associated with endometrial cancer risk. Further data are needed to confirm these findings and to examine the mechanisms linking coffee intake to endometrial cancer risk to develop improved prevention strategies. Cancer Epidemiol Biomarkers Prev; 24(2); 466-71. ©2015 AACR. (Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cancer Epidemiology Biomarkers & Prevention
volume
24
issue
2
pages
466 - 471
publisher
American Association for Cancer Research
external identifiers
  • pmid:25662427
  • wos:000349422500020
  • scopus:84922735651
ISSN
1538-7755
DOI
10.1158/1055-9965.EPI-14-0970
language
English
LU publication?
yes
id
2cd2e11f-f6d2-4271-949b-73fd4126bdbc (old id 5145015)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25662427?dopt=Abstract
date added to LUP
2015-03-05 17:28:15
date last changed
2017-09-24 03:19:54
@article{2cd2e11f-f6d2-4271-949b-73fd4126bdbc,
  abstract     = {Data on the role of dietary factors in endometrial cancer development are limited and inconsistent. We applied a "nutrient-wide association study" approach to systematically evaluate dietary risk associations for endometrial cancer while controlling for multiple hypothesis tests using the false discovery rate (FDR) and validating the results in an independent cohort. We evaluated endometrial cancer risk associations for dietary intake of 84 foods and nutrients based on dietary questionnaires in three prospective studies, the European Prospective Investigation into Cancer and Nutrition (EPIC; N = 1,303 cases) followed by validation of nine foods/nutrients (FDR ≤ 0.10) in the Nurses' Health Studies (NHS/NHSII; N = 1,531 cases). Cox regression models were used to estimate HRs and 95% confidence intervals (CI). In multivariate adjusted comparisons of the extreme categories of intake at baseline, coffee was inversely associated with endometrial cancer risk (EPIC, median intake 750 g/day vs. 8.6; HR, 0.81; 95% CI, 0.68-0.97, Ptrend = 0.09; NHS/NHSII, median intake 1067 g/day vs. none; HR, 0.82; 95% CI, 0.70-0.96, Ptrend = 0.04). Eight other dietary factors that were associated with endometrial cancer risk in the EPIC study (total fat, monounsaturated fat, carbohydrates, phosphorus, butter, yogurt, cheese, and potatoes) were not confirmed in the NHS/NHSII. Our findings suggest that coffee intake may be inversely associated with endometrial cancer risk. Further data are needed to confirm these findings and to examine the mechanisms linking coffee intake to endometrial cancer risk to develop improved prevention strategies. Cancer Epidemiol Biomarkers Prev; 24(2); 466-71. ©2015 AACR.},
  author       = {Merritt, Melissa A and Tzoulaki, Ioanna and Tworoger, Shelley S and De Vivo, Immaculata and Hankinson, Susan E and Fernandes, Judy and Tsilidis, Konstantinos K and Weiderpass, Elisabete and Tjønneland, Anne and Petersen, Kristina E N and Dahm, Christina C and Overvad, Kim and Dossus, Laure and Boutron-Ruault, Marie-Christine and Fagherazzi, Guy and Fortner, Renée T and Kaaks, Rudolf and Aleksandrova, Krasimira and Boeing, Heiner and Trichopoulou, Antonia and Bamia, Christina and Trichopoulos, Dimitrios and Palli, Domenico and Grioni, Sara and Tumino, Rosario and Sacerdote, Carlotta and Mattiello, Amalia and Bueno-de-Mesquita, H B As and Onland-Moret, N Charlotte and Peeters, Petra H and Gram, Inger T and Skeie, Guri and Quirós, J Ramón and Duell, Eric J and Sánchez, María-José and Salmerón, D and Barricarte, Aurelio and Chamosa, Saioa and Ericson, Ulrica and Sonestedt, Emily and Nilsson, Lena Maria and Idahl, Annika and Khaw, Kay-Tee and Wareham, Nicholas and Travis, Ruth C and Rinaldi, Sabina and Romieu, Isabelle and Patel, Chirag J and Riboli, Elio and Gunter, Marc J},
  issn         = {1538-7755},
  language     = {eng},
  number       = {2},
  pages        = {466--471},
  publisher    = {American Association for Cancer Research},
  series       = {Cancer Epidemiology Biomarkers & Prevention},
  title        = {Investigation of Dietary Factors and Endometrial Cancer Risk Using a Nutrient-wide Association Study Approach in the EPIC and Nurses' Health Study (NHS) and NHSII.},
  url          = {http://dx.doi.org/10.1158/1055-9965.EPI-14-0970},
  volume       = {24},
  year         = {2015},
}