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Auditory event-related potentials are related to cognition at preschool age after preterm birth

Hövel, Holger LU ; Partanen, E; Tideman, Eva LU ; Stjernqvist, Karin LU ; Hellström-Westas, Lena LU ; Houtilainen, M and Fellman, Vineta LU (2015) In Pediatric Research 77(4). p.570-578
Abstract
Background:Auditory event-related potentials (AERP) are neurophysiological correlates of sound perception and cognitive processes. Our aim was to study in very preterm born children at preschool age if AERP correlate with cognitive outcome.Methods:Seventy children (mean ± SD gestational age 27.4 ± 1.9 wk, birth weight 996 ± 288 g) were investigated at age 4.3-5.3 y with psychological testing (WPPSI-R, four subtests of NEPSY). Electroencephalogram was recorded while they listened to a repeated standard tone, randomly replaced by one of three deviants. Latencies and amplitudes for AERP components and mean amplitudes in successive 50-ms AERP time windows were measured.Results:Better cognitive test results and higher gestational age correlated... (More)
Background:Auditory event-related potentials (AERP) are neurophysiological correlates of sound perception and cognitive processes. Our aim was to study in very preterm born children at preschool age if AERP correlate with cognitive outcome.Methods:Seventy children (mean ± SD gestational age 27.4 ± 1.9 wk, birth weight 996 ± 288 g) were investigated at age 4.3-5.3 y with psychological testing (WPPSI-R, four subtests of NEPSY). Electroencephalogram was recorded while they listened to a repeated standard tone, randomly replaced by one of three deviants. Latencies and amplitudes for AERP components and mean amplitudes in successive 50-ms AERP time windows were measured.Results:Better cognitive test results and higher gestational age correlated with shorter P1 latencies and more positive mean amplitudes 150-500 ms after stimulus change onset. Neonatal brain damage was associated with a negative displacement of AERP curves. Neonatal morbidity had an impact on earlier time windows while gestational age and brain damage on both early and later time windows.Conclusion:AERP measures were associated with cognitive outcome. Neonatal morbidity mainly affects early cortical auditory encoding, while immaturity and brain damage additionally influence higher cortical functions of auditory perception and distraction. Perinatal auditory environment might play a role in development of auditory processing.Pediatric Research (2015); doi:10.1038/pr.2015.7. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Pediatric Research
volume
77
issue
4
pages
570 - 578
publisher
International Pediatric Foundation Inc.
external identifiers
  • scopus:84924976085
  • pmid:25642663
  • wos:000351335600011
ISSN
1530-0447
DOI
10.1038/pr.2015.7
language
English
LU publication?
yes
id
53c13319-0873-4024-99e7-cf8c4201f917 (old id 5158405)
date added to LUP
2015-03-03 16:19:08
date last changed
2017-01-01 03:53:06
@article{53c13319-0873-4024-99e7-cf8c4201f917,
  abstract     = {Background:Auditory event-related potentials (AERP) are neurophysiological correlates of sound perception and cognitive processes. Our aim was to study in very preterm born children at preschool age if AERP correlate with cognitive outcome.Methods:Seventy children (mean ± SD gestational age 27.4 ± 1.9 wk, birth weight 996 ± 288 g) were investigated at age 4.3-5.3 y with psychological testing (WPPSI-R, four subtests of NEPSY). Electroencephalogram was recorded while they listened to a repeated standard tone, randomly replaced by one of three deviants. Latencies and amplitudes for AERP components and mean amplitudes in successive 50-ms AERP time windows were measured.Results:Better cognitive test results and higher gestational age correlated with shorter P1 latencies and more positive mean amplitudes 150-500 ms after stimulus change onset. Neonatal brain damage was associated with a negative displacement of AERP curves. Neonatal morbidity had an impact on earlier time windows while gestational age and brain damage on both early and later time windows.Conclusion:AERP measures were associated with cognitive outcome. Neonatal morbidity mainly affects early cortical auditory encoding, while immaturity and brain damage additionally influence higher cortical functions of auditory perception and distraction. Perinatal auditory environment might play a role in development of auditory processing.Pediatric Research (2015); doi:10.1038/pr.2015.7.},
  author       = {Hövel, Holger and Partanen, E and Tideman, Eva and Stjernqvist, Karin and Hellström-Westas, Lena and Houtilainen, M and Fellman, Vineta},
  issn         = {1530-0447},
  language     = {eng},
  number       = {4},
  pages        = {570--578},
  publisher    = {International Pediatric Foundation Inc.},
  series       = {Pediatric Research},
  title        = {Auditory event-related potentials are related to cognition at preschool age after preterm birth},
  url          = {http://dx.doi.org/10.1038/pr.2015.7},
  volume       = {77},
  year         = {2015},
}