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Pregnancy serum concentrations of perfluorinated alkyl substances and offspring behaviour and motor development at age 5-9 years - a prospective study

Hoyer, Birgit Bjerre; Ramlau-Hansen, Cecilia Host; Obel, Carsten; Pedersen, Henning Sloth; Hernik, Agnieszka; Ogniev, Victor; Jönsson, Bo A LU ; Lindh, Christian LU ; Rylander, Lars LU and Rignell-Hydbom, Anna LU , et al. (2015) In Environmental Health 14(2). p.1-11
Abstract
Background: In animal studies, perfluorinated alkyl substances affect growth and neuro-behavioural outcomes. Human epidemiological studies are sparse. The aim was to investigate the association between pregnancy serum concentrations of perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) and offspring behaviour and motor development at 5-9 years of age. Methods: Maternal sera from the INUENDO cohort (2002-2004) comprising 1,106 mother-child pairs from Greenland, Kharkiv (Ukraine) and Warsaw (Poland) were analysed for PFOS and PFOA, using liquid-chromatography-tandem-mass-spectrometry. Exposures were grouped into country specific as well as pooled tertiles as well as being used as continuous variables for statistical analyses.... (More)
Background: In animal studies, perfluorinated alkyl substances affect growth and neuro-behavioural outcomes. Human epidemiological studies are sparse. The aim was to investigate the association between pregnancy serum concentrations of perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) and offspring behaviour and motor development at 5-9 years of age. Methods: Maternal sera from the INUENDO cohort (2002-2004) comprising 1,106 mother-child pairs from Greenland, Kharkiv (Ukraine) and Warsaw (Poland) were analysed for PFOS and PFOA, using liquid-chromatography-tandem-mass-spectrometry. Exposures were grouped into country specific as well as pooled tertiles as well as being used as continuous variables for statistical analyses. Child motor development and behaviour at follow-up (2010-2012) were measured by the Developmental Coordination Disorder Questionnaire 2007 (DCDQ) and Strength and Difficulties Questionnaire (SDQ), respectively. Exposure-outcome associations were analysed by multiple logistic and linear regression analyses. Results: In the pooled analysis, odds ratio (OR) (95% confidence interval (CI)) for hyperactivity was 3.1 (1.3, 7.2) comparing children prenatally exposed to the highest PFOA tertile with those exposed to the lowest PFOA tertile. Comparing children in the highest PFOS tertile with those in the lowest PFOS tertile showed elevated but statistically non-significant OR of hyperactivity (OR (95% CI) 1.7 (0.9, 3.2)). In Greenland, elevated PFOS was associated with higher SDQ-total scores indicating more behavioural problems (beta (95% CI) = 1.0 (0.1, 2.0)) and elevated PFOA was associated with higher hyperactivity sub-scale scores indicating more hyperactive behaviour (beta (95% CI) = 0.5 (0.1, 0.9)). Prenatal PFOS and PFOA exposures were not associated with motor difficulties. Conclusions: Prenatal exposure to PFOS and PFOA may have a small to moderate effect on children's neuro-behavioural development, specifically in terms of hyperactive behaviour. The associations were strongest in Greenland where exposure contrast is largest. (Less)
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Contribution to journal
publication status
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subject
keywords
Behaviour, Child, Child development, Cohort study, Motor development, Perfluorooctanoate (PFOA), Perfluorooctane sulfonate (PFOS), Prenatal, exposure, Delayed effects
in
Environmental Health
volume
14
issue
2
pages
1 - 11
publisher
BioMed Central
external identifiers
  • wos:000349477400001
  • scopus:84988964939
ISSN
1476-069X
DOI
10.1186/1476-069X-14-2
language
English
LU publication?
yes
id
1c185604-7e02-4b2f-b588-b057ac4a88e7 (old id 5179939)
date added to LUP
2015-04-01 07:35:39
date last changed
2017-10-01 04:10:24
@article{1c185604-7e02-4b2f-b588-b057ac4a88e7,
  abstract     = {Background: In animal studies, perfluorinated alkyl substances affect growth and neuro-behavioural outcomes. Human epidemiological studies are sparse. The aim was to investigate the association between pregnancy serum concentrations of perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) and offspring behaviour and motor development at 5-9 years of age. Methods: Maternal sera from the INUENDO cohort (2002-2004) comprising 1,106 mother-child pairs from Greenland, Kharkiv (Ukraine) and Warsaw (Poland) were analysed for PFOS and PFOA, using liquid-chromatography-tandem-mass-spectrometry. Exposures were grouped into country specific as well as pooled tertiles as well as being used as continuous variables for statistical analyses. Child motor development and behaviour at follow-up (2010-2012) were measured by the Developmental Coordination Disorder Questionnaire 2007 (DCDQ) and Strength and Difficulties Questionnaire (SDQ), respectively. Exposure-outcome associations were analysed by multiple logistic and linear regression analyses. Results: In the pooled analysis, odds ratio (OR) (95% confidence interval (CI)) for hyperactivity was 3.1 (1.3, 7.2) comparing children prenatally exposed to the highest PFOA tertile with those exposed to the lowest PFOA tertile. Comparing children in the highest PFOS tertile with those in the lowest PFOS tertile showed elevated but statistically non-significant OR of hyperactivity (OR (95% CI) 1.7 (0.9, 3.2)). In Greenland, elevated PFOS was associated with higher SDQ-total scores indicating more behavioural problems (beta (95% CI) = 1.0 (0.1, 2.0)) and elevated PFOA was associated with higher hyperactivity sub-scale scores indicating more hyperactive behaviour (beta (95% CI) = 0.5 (0.1, 0.9)). Prenatal PFOS and PFOA exposures were not associated with motor difficulties. Conclusions: Prenatal exposure to PFOS and PFOA may have a small to moderate effect on children's neuro-behavioural development, specifically in terms of hyperactive behaviour. The associations were strongest in Greenland where exposure contrast is largest.},
  author       = {Hoyer, Birgit Bjerre and Ramlau-Hansen, Cecilia Host and Obel, Carsten and Pedersen, Henning Sloth and Hernik, Agnieszka and Ogniev, Victor and Jönsson, Bo A and Lindh, Christian and Rylander, Lars and Rignell-Hydbom, Anna and Bonde, Jens Peter and Toft, Gunnar},
  issn         = {1476-069X},
  keyword      = {Behaviour,Child,Child development,Cohort study,Motor development,Perfluorooctanoate (PFOA),Perfluorooctane sulfonate (PFOS),Prenatal,exposure,Delayed effects},
  language     = {eng},
  number       = {2},
  pages        = {1--11},
  publisher    = {BioMed Central},
  series       = {Environmental Health},
  title        = {Pregnancy serum concentrations of perfluorinated alkyl substances and offspring behaviour and motor development at age 5-9 years - a prospective study},
  url          = {http://dx.doi.org/10.1186/1476-069X-14-2},
  volume       = {14},
  year         = {2015},
}