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Keratin 19 expression correlates with poor prognosis in breast cancer

Kabir, Nuzhat N.; Rönnstrand, Lars LU and Kazi, Julhash U. LU (2014) In Molecular Biology Reports 41(12). p.7729-7735
Abstract
Breast cancer expression profiling has been used for determining biomarkers. Using gene expression profiles of 2,400 patients we identified keratin 19 (KRT19) as a highly deregulated gene in breast cancer. KRT19 expression is independent of patient race but correlates with disease grade, and ER, PR or HER2 expression. Expression of TPD52, GATA3 and KRT18 was increased in KRT19 expressing patients. Furthermore, KRT19 expression was associated with ER up-regulation and Luminal B gene signatures, as well as a constitutive RAF1 signaling pathway. Finally, KRT19 expression correlated with poor overall survival. Taken together, our results suggest that KRT19 expression can be used as a prognostic marker.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cytokeratin 19, CK19, KRT19, Microarray
in
Molecular Biology Reports
volume
41
issue
12
pages
7729 - 7735
publisher
Springer
external identifiers
  • wos:000349005800002
  • scopus:84926635773
ISSN
0301-4851
DOI
10.1007/s11033-014-3684-6
language
English
LU publication?
yes
id
6910da15-3011-416d-98ee-d66518f36395 (old id 5204293)
date added to LUP
2015-04-01 07:37:23
date last changed
2017-10-01 04:17:50
@article{6910da15-3011-416d-98ee-d66518f36395,
  abstract     = {Breast cancer expression profiling has been used for determining biomarkers. Using gene expression profiles of 2,400 patients we identified keratin 19 (KRT19) as a highly deregulated gene in breast cancer. KRT19 expression is independent of patient race but correlates with disease grade, and ER, PR or HER2 expression. Expression of TPD52, GATA3 and KRT18 was increased in KRT19 expressing patients. Furthermore, KRT19 expression was associated with ER up-regulation and Luminal B gene signatures, as well as a constitutive RAF1 signaling pathway. Finally, KRT19 expression correlated with poor overall survival. Taken together, our results suggest that KRT19 expression can be used as a prognostic marker.},
  author       = {Kabir, Nuzhat N. and Rönnstrand, Lars and Kazi, Julhash U.},
  issn         = {0301-4851},
  keyword      = {Cytokeratin 19,CK19,KRT19,Microarray},
  language     = {eng},
  number       = {12},
  pages        = {7729--7735},
  publisher    = {Springer},
  series       = {Molecular Biology Reports},
  title        = {Keratin 19 expression correlates with poor prognosis in breast cancer},
  url          = {http://dx.doi.org/10.1007/s11033-014-3684-6},
  volume       = {41},
  year         = {2014},
}