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RIFM fragrance ingredient safety assessment, α-irone, CAS registry number 79-69-6.

Api, A M; Belsito, D; Bhatia, S; Bruze, Magnus LU ; Calow, P; Dagli, M L; Dekant, W; Fryer, A D; Kromidas, L and Cava, S LA, et al. (2015) In Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Abstract
The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential as well as environmental assessment. Repeated Dose Toxicity was determined to have the most conservative systemic exposure derived NO[A]EL of 5.2 mg/kg/day, based on a dietary 90-day subchronic toxicity study conducted in rats, that resulted in a MOE of 852, considering 100% absorption from skin contact and inhalation. A MOE of >100 is deemed acceptable.
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published
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Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
publisher
Elsevier
external identifiers
  • pmid:25817021
  • scopus:84934443221
ISSN
1873-6351
DOI
10.1016/j.fct.2015.03.019
language
English
LU publication?
yes
id
e7051993-4272-49db-97eb-a51886a11ce2 (old id 5257484)
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http://www.ncbi.nlm.nih.gov/pubmed/25817021?dopt=Abstract
date added to LUP
2015-04-04 16:55:24
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2017-01-01 07:50:39
@article{e7051993-4272-49db-97eb-a51886a11ce2,
  abstract     = {The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential as well as environmental assessment. Repeated Dose Toxicity was determined to have the most conservative systemic exposure derived NO[A]EL of 5.2 mg/kg/day, based on a dietary 90-day subchronic toxicity study conducted in rats, that resulted in a MOE of 852, considering 100% absorption from skin contact and inhalation. A MOE of >100 is deemed acceptable.},
  author       = {Api, A M and Belsito, D and Bhatia, S and Bruze, Magnus and Calow, P and Dagli, M L and Dekant, W and Fryer, A D and Kromidas, L and Cava, S LA and Lalko, J F and Lapczynski, A and Liebler, D C and Miyachi, Y and Politano, V T and Ritacco, G and Salvito, D and Shen, J and Schultz, T W and Sipes, I G and Wall, B and Wilcox, D K},
  issn         = {1873-6351},
  language     = {eng},
  month        = {03},
  publisher    = {Elsevier},
  series       = {Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  title        = {RIFM fragrance ingredient safety assessment, α-irone, CAS registry number 79-69-6.},
  url          = {http://dx.doi.org/10.1016/j.fct.2015.03.019},
  year         = {2015},
}