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Role of SRC-like adaptor protein (SLAP) in immune and malignant cell signaling.

Kazi, Julhash U. LU ; Kabir, Nuzhat N and Rönnstrand, Lars LU (2015) In Cellular and Molecular Life Sciences 72(13). p.2535-2544
Abstract
SRC-like adaptor protein (SLAP) is an adaptor protein structurally similar to the SRC family protein kinases. Like SRC, SLAP contains an SH3 domain followed by an SH2 domain but the kinase domain has been replaced by a unique C-terminal region. SLAP is expressed in a variety of cell types. Current studies suggest that it regulates signaling of various cell surface receptors including the B cell receptor, the T cell receptor, cytokine receptors and receptor tyrosine kinases which are important regulator of immune and cancer cell signaling. SLAP targets receptors, or its associated components, by recruiting the ubiquitin machinery and thereby destabilizing signaling. SLAP directs receptors to ubiquitination-mediated degradation and controls... (More)
SRC-like adaptor protein (SLAP) is an adaptor protein structurally similar to the SRC family protein kinases. Like SRC, SLAP contains an SH3 domain followed by an SH2 domain but the kinase domain has been replaced by a unique C-terminal region. SLAP is expressed in a variety of cell types. Current studies suggest that it regulates signaling of various cell surface receptors including the B cell receptor, the T cell receptor, cytokine receptors and receptor tyrosine kinases which are important regulator of immune and cancer cell signaling. SLAP targets receptors, or its associated components, by recruiting the ubiquitin machinery and thereby destabilizing signaling. SLAP directs receptors to ubiquitination-mediated degradation and controls receptors turnover as well as signaling. Thus, SLAP appears to be an important component in regulating signal transduction required for immune and malignant cells. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cellular and Molecular Life Sciences
volume
72
issue
13
pages
2535 - 2544
publisher
Birkhaüser
external identifiers
  • pmid:25772501
  • wos:000355751300005
  • scopus:84930537998
ISSN
1420-9071
DOI
10.1007/s00018-015-1882-6
language
English
LU publication?
yes
id
7fb7d10d-4758-457a-802b-5d5a057bdd1e (old id 5258642)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25772501?dopt=Abstract
date added to LUP
2015-04-03 19:07:34
date last changed
2017-11-05 03:26:41
@article{7fb7d10d-4758-457a-802b-5d5a057bdd1e,
  abstract     = {SRC-like adaptor protein (SLAP) is an adaptor protein structurally similar to the SRC family protein kinases. Like SRC, SLAP contains an SH3 domain followed by an SH2 domain but the kinase domain has been replaced by a unique C-terminal region. SLAP is expressed in a variety of cell types. Current studies suggest that it regulates signaling of various cell surface receptors including the B cell receptor, the T cell receptor, cytokine receptors and receptor tyrosine kinases which are important regulator of immune and cancer cell signaling. SLAP targets receptors, or its associated components, by recruiting the ubiquitin machinery and thereby destabilizing signaling. SLAP directs receptors to ubiquitination-mediated degradation and controls receptors turnover as well as signaling. Thus, SLAP appears to be an important component in regulating signal transduction required for immune and malignant cells.},
  author       = {Kazi, Julhash U. and Kabir, Nuzhat N and Rönnstrand, Lars},
  issn         = {1420-9071},
  language     = {eng},
  number       = {13},
  pages        = {2535--2544},
  publisher    = {Birkhaüser},
  series       = {Cellular and Molecular Life Sciences},
  title        = {Role of SRC-like adaptor protein (SLAP) in immune and malignant cell signaling.},
  url          = {http://dx.doi.org/10.1007/s00018-015-1882-6},
  volume       = {72},
  year         = {2015},
}