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SOCS6 (suppressor of cytokine signaling 6)

Kazi, Julhash U. LU orcid ; Flores-Morales, Amilcar and Rönnstrand, Lars LU orcid (2015) In Atlas of Genetics and Cytogenetics in Oncology and Haematology 19(1). p.50-52
Abstract
The suppressor of cytokine signaling (SOCS) family of proteins are well known negative regulators of cytokine receptors signaling consisting of eight structurally similar proteins, SOCS1-7 and CIS. A key feature of this family of proteins is the presence of two structural motifs: a centrally located SH2 domain and a SOCS box in the C-terminus. The SOCS box mediates the interaction with the Elongins B and C complex while an additional motif mediates its interaction with Cullin 5 to assemble a Cullin/Ring ubiquitin ligase. In this complex SOCS6 acts as a substrate recognition subunit through interactions mediated by the N-terminus and the SH2 domain. SOCS6 interacts with tyrosine kinase receptors FLT3 and c-KIT and modulate their... (More)
The suppressor of cytokine signaling (SOCS) family of proteins are well known negative regulators of cytokine receptors signaling consisting of eight structurally similar proteins, SOCS1-7 and CIS. A key feature of this family of proteins is the presence of two structural motifs: a centrally located SH2 domain and a SOCS box in the C-terminus. The SOCS box mediates the interaction with the Elongins B and C complex while an additional motif mediates its interaction with Cullin 5 to assemble a Cullin/Ring ubiquitin ligase. In this complex SOCS6 acts as a substrate recognition subunit through interactions mediated by the N-terminus and the SH2 domain. SOCS6 interacts with tyrosine kinase receptors FLT3 and c-KIT and modulate their ubiquitination and function. (Less)
Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
CIS4, SSI4, CIS-4, SOCS4, STAI4, SOCS-4, SOCS-6, STATI4, HSPC060.
in
Atlas of Genetics and Cytogenetics in Oncology and Haematology
volume
19
issue
1
pages
50 - 52
publisher
Atlas of genetics and cytogenetics in oncology and haematology
ISSN
1768-3262
DOI
10.4267/2042/55379
language
English
LU publication?
yes
id
07f19313-6137-4424-9174-c861798245d9 (old id 5268045)
date added to LUP
2016-04-01 13:57:36
date last changed
2019-11-26 03:17:23
@article{07f19313-6137-4424-9174-c861798245d9,
  abstract     = {{The suppressor of cytokine signaling (SOCS) family of proteins are well known negative regulators of cytokine receptors signaling consisting of eight structurally similar proteins, SOCS1-7 and CIS. A key feature of this family of proteins is the presence of two structural motifs: a centrally located SH2 domain and a SOCS box in the C-terminus. The SOCS box mediates the interaction with the Elongins B and C complex while an additional motif mediates its interaction with Cullin 5 to assemble a Cullin/Ring ubiquitin ligase. In this complex SOCS6 acts as a substrate recognition subunit through interactions mediated by the N-terminus and the SH2 domain. SOCS6 interacts with tyrosine kinase receptors FLT3 and c-KIT and modulate their ubiquitination and function.}},
  author       = {{Kazi, Julhash U. and Flores-Morales, Amilcar and Rönnstrand, Lars}},
  issn         = {{1768-3262}},
  keywords     = {{CIS4; SSI4; CIS-4; SOCS4; STAI4; SOCS-4; SOCS-6; STATI4; HSPC060.}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{50--52}},
  publisher    = {{Atlas of genetics and cytogenetics in oncology and haematology}},
  series       = {{Atlas of Genetics and Cytogenetics in Oncology and Haematology}},
  title        = {{SOCS6 (suppressor of cytokine signaling 6)}},
  url          = {{http://dx.doi.org/10.4267/2042/55379}},
  doi          = {{10.4267/2042/55379}},
  volume       = {{19}},
  year         = {{2015}},
}