Advanced

SOCS6 (suppressor of cytokine signaling 6)

Kazi, Julhash U. LU ; Flores-Morales, Amilcar and Rönnstrand, Lars LU (2014) In Atlas of Genetics and Cytogenetics in Oncology and Haematology 19(1). p.50-52
Abstract
The suppressor of cytokine signaling (SOCS) family of proteins are well known negative regulators of cytokine receptors signaling consisting of eight structurally similar proteins, SOCS1-7 and CIS. A key feature of this family of proteins is the presence of two structural motifs: a centrally located SH2 domain and a SOCS box in the C-terminus. The SOCS box mediates the interaction with the Elongins B and C complex while an additional motif mediates its interaction with Cullin 5 to assemble a Cullin/Ring ubiquitin ligase. In this complex SOCS6 acts as a substrate recognition subunit through interactions mediated by the N-terminus and the SH2 domain. SOCS6 interacts with tyrosine kinase receptors FLT3 and c-KIT and modulate their... (More)
The suppressor of cytokine signaling (SOCS) family of proteins are well known negative regulators of cytokine receptors signaling consisting of eight structurally similar proteins, SOCS1-7 and CIS. A key feature of this family of proteins is the presence of two structural motifs: a centrally located SH2 domain and a SOCS box in the C-terminus. The SOCS box mediates the interaction with the Elongins B and C complex while an additional motif mediates its interaction with Cullin 5 to assemble a Cullin/Ring ubiquitin ligase. In this complex SOCS6 acts as a substrate recognition subunit through interactions mediated by the N-terminus and the SH2 domain. SOCS6 interacts with tyrosine kinase receptors FLT3 and c-KIT and modulate their ubiquitination and function. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
CIS4, SSI4, CIS-4, SOCS4, STAI4, SOCS-4, SOCS-6, STATI4, HSPC060.
in
Atlas of Genetics and Cytogenetics in Oncology and Haematology
volume
19
issue
1
pages
50 - 52
publisher
ARMGHM / NIST - CNRS
ISSN
1768-3262
DOI
10.4267/2042/55379
language
English
LU publication?
yes
id
07f19313-6137-4424-9174-c861798245d9 (old id 5268045)
date added to LUP
2015-08-03 11:30:15
date last changed
2017-02-19 14:34:30
@article{07f19313-6137-4424-9174-c861798245d9,
  abstract     = {The suppressor of cytokine signaling (SOCS) family of proteins are well known negative regulators of cytokine receptors signaling consisting of eight structurally similar proteins, SOCS1-7 and CIS. A key feature of this family of proteins is the presence of two structural motifs: a centrally located SH2 domain and a SOCS box in the C-terminus. The SOCS box mediates the interaction with the Elongins B and C complex while an additional motif mediates its interaction with Cullin 5 to assemble a Cullin/Ring ubiquitin ligase. In this complex SOCS6 acts as a substrate recognition subunit through interactions mediated by the N-terminus and the SH2 domain. SOCS6 interacts with tyrosine kinase receptors FLT3 and c-KIT and modulate their ubiquitination and function.},
  author       = {Kazi, Julhash U. and Flores-Morales, Amilcar and Rönnstrand, Lars},
  issn         = {1768-3262},
  keyword      = {CIS4,SSI4,CIS-4,SOCS4,STAI4,SOCS-4,SOCS-6,STATI4,HSPC060.},
  language     = {eng},
  number       = {1},
  pages        = {50--52},
  publisher    = {ARMGHM / NIST - CNRS},
  series       = {Atlas of Genetics and Cytogenetics in Oncology and Haematology},
  title        = {SOCS6 (suppressor of cytokine signaling 6)},
  url          = {http://dx.doi.org/10.4267/2042/55379},
  volume       = {19},
  year         = {2014},
}