Effects of a high-fat diet during pregnancy and lactation are modulated by E. coli in rat offspring
(2012) In International Journal of Obesity 36(5). p.744-751- Abstract
- Objective: Microbial manipulations in early life can affect gut development and inflammatory status of the neonate. The maternal diet during pregnancy and lactation also influences the health of the offspring, but the impact of maternal high-fat (HF) feeding along with modulations of the gut microbiota on body weight, fat deposition and gut function in the offspring has been poorly studied. Methods: Rat dams were given access to either an HF or a standard low-fat diet during the last 2 weeks of pregnancy and during lactation and effects on body weight and gastrointestinal function were investigated in the 14-day-old offspring. To elucidate whether bacterial administration to the dam could modulate any effects of the diets in the rat pups,... (More)
- Objective: Microbial manipulations in early life can affect gut development and inflammatory status of the neonate. The maternal diet during pregnancy and lactation also influences the health of the offspring, but the impact of maternal high-fat (HF) feeding along with modulations of the gut microbiota on body weight, fat deposition and gut function in the offspring has been poorly studied. Methods: Rat dams were given access to either an HF or a standard low-fat diet during the last 2 weeks of pregnancy and during lactation and effects on body weight and gastrointestinal function were investigated in the 14-day-old offspring. To elucidate whether bacterial administration to the dam could modulate any effects of the diets in the rat pups, another group of dams were given Escherichia coli in their drinking water. Results: Maternal HF feeding resulted in increased body and fat pad weights in the offspring, along with increased levels of the acute-phase protein, haptoglobin and decreased protein content and disaccharidase activities in the small intestine. The addition of E. coli further accentuated these responses in the young rats, which, in addition to higher body weights and increased fat deposition, also showed an increased intestinal permeability and elevated levels of haptoglobin. Conclusions: The present study demonstrates for the first time how bacterial administration to the maternal diet during the neonatal period can affect body weight and fat deposition in the offspring. The results point to a mechanistic link between the gut microbiota, increased intestinal permeability and metabolic endotoxemia, which appear to have led to increased adiposity in the young rats. International Journal of Obesity (2012) 36, 744-751; doi:10.1038/ijo.2011.118; published online 5 July 2011 (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2826746
- author
- Fak, Frida ; Linninge, Caroline LU ; Ahrné, Siv LU ; Molin, Göran LU and Weström, Björn LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- bacteria, gastrointestinal, rat, body weight, fat, permeability
- in
- International Journal of Obesity
- volume
- 36
- issue
- 5
- pages
- 744 - 751
- publisher
- Nature Publishing Group
- external identifiers
-
- wos:000303771000015
- scopus:84860778010
- pmid:21730967
- ISSN
- 1476-5497
- DOI
- 10.1038/ijo.2011.118
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Applied Nutrition and Food Chemistry (011001300), Functional Zoology (432112239)
- id
- 52cff112-6e2f-4317-80c2-9e346ba453d5 (old id 2826746)
- date added to LUP
- 2016-04-01 11:10:51
- date last changed
- 2023-11-10 14:15:02
@article{52cff112-6e2f-4317-80c2-9e346ba453d5,
abstract = {{Objective: Microbial manipulations in early life can affect gut development and inflammatory status of the neonate. The maternal diet during pregnancy and lactation also influences the health of the offspring, but the impact of maternal high-fat (HF) feeding along with modulations of the gut microbiota on body weight, fat deposition and gut function in the offspring has been poorly studied. Methods: Rat dams were given access to either an HF or a standard low-fat diet during the last 2 weeks of pregnancy and during lactation and effects on body weight and gastrointestinal function were investigated in the 14-day-old offspring. To elucidate whether bacterial administration to the dam could modulate any effects of the diets in the rat pups, another group of dams were given Escherichia coli in their drinking water. Results: Maternal HF feeding resulted in increased body and fat pad weights in the offspring, along with increased levels of the acute-phase protein, haptoglobin and decreased protein content and disaccharidase activities in the small intestine. The addition of E. coli further accentuated these responses in the young rats, which, in addition to higher body weights and increased fat deposition, also showed an increased intestinal permeability and elevated levels of haptoglobin. Conclusions: The present study demonstrates for the first time how bacterial administration to the maternal diet during the neonatal period can affect body weight and fat deposition in the offspring. The results point to a mechanistic link between the gut microbiota, increased intestinal permeability and metabolic endotoxemia, which appear to have led to increased adiposity in the young rats. International Journal of Obesity (2012) 36, 744-751; doi:10.1038/ijo.2011.118; published online 5 July 2011}},
author = {{Fak, Frida and Linninge, Caroline and Ahrné, Siv and Molin, Göran and Weström, Björn}},
issn = {{1476-5497}},
keywords = {{bacteria; gastrointestinal; rat; body weight; fat; permeability}},
language = {{eng}},
number = {{5}},
pages = {{744--751}},
publisher = {{Nature Publishing Group}},
series = {{International Journal of Obesity}},
title = {{Effects of a high-fat diet during pregnancy and lactation are modulated by E. coli in rat offspring}},
url = {{http://dx.doi.org/10.1038/ijo.2011.118}},
doi = {{10.1038/ijo.2011.118}},
volume = {{36}},
year = {{2012}},
}