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Coffee, tea and decaffeinated coffee in relation to hepatocellular carcinoma in a European population: Multicentre, prospective cohort study

Bamia, Christina; Lagiou, Pagona; Jenab, Mazda; Trichopoulou, Antonia; Fedirko, Veronika; Aleksandrova, Krasimira; Pischon, Tobias; Overvad, Kim; Olsen, Anja and Tjonneland, Anne, et al. (2015) In International Journal of Cancer 136(8). p.1899-1908
Abstract
Inverse associations of coffee and/or tea in relation to hepatocellular carcinoma (HCC) risk have been consistently identified in studies conducted mostly in Asia where consumption patterns of such beverages differ from Europe. In the European Prospective Investigation into Cancer and nutrition (EPIC), we identified 201 HCC cases among 486,799 men/women, after a median follow-up of 11 years. We calculated adjusted hazard ratios (HRs) for HCC incidence in relation to quintiles/categories of coffee/tea intakes. We found that increased coffee and tea intakes were consistently associated with lower HCC risk. The inverse associations were substantial, monotonic and statistically significant. Coffee consumers in the highest compared to the... (More)
Inverse associations of coffee and/or tea in relation to hepatocellular carcinoma (HCC) risk have been consistently identified in studies conducted mostly in Asia where consumption patterns of such beverages differ from Europe. In the European Prospective Investigation into Cancer and nutrition (EPIC), we identified 201 HCC cases among 486,799 men/women, after a median follow-up of 11 years. We calculated adjusted hazard ratios (HRs) for HCC incidence in relation to quintiles/categories of coffee/tea intakes. We found that increased coffee and tea intakes were consistently associated with lower HCC risk. The inverse associations were substantial, monotonic and statistically significant. Coffee consumers in the highest compared to the lowest quintile had lower HCC risk by 72% [HR: 0.28; 95% confidence intervals (CIs): 0.16-0.50, p-trend<0.001]. The corresponding association of tea with HCC risk was 0.41 (95% CI: 0.22-0.78, p-trend=0.003). There was no compelling evidence of heterogeneity of these associations across strata of important HCC risk factors, including hepatitis B or hepatitis C status (available in a nested case-control study). The inverse, monotonic associations of coffee intake with HCC were apparent for caffeinated (p-trend=0.009), but not decaffeinated (p-trend=0.45) coffee for which, however, data were available for a fraction of subjects. Results from this multicentre, European cohort study strengthen the existing evidence regarding the inverse association between coffee/tea and HCC risk. Given the apparent lack of heterogeneity of these associations by HCC risk factors and that coffee/tea are universal exposures, our results could have important implications for high HCC risk subjects. (Less)
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publication status
published
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keywords
hepatocellular carcinoma, liver cancer, coffee, tea, EPIC
in
International Journal of Cancer
volume
136
issue
8
pages
1899 - 1908
publisher
John Wiley & Sons
external identifiers
  • wos:000349619000016
  • scopus:84922567205
ISSN
0020-7136
DOI
10.1002/ijc.29214
language
English
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yes
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b4d46f8e-0a9c-43fd-93fe-f1d97af193dc (old id 5305027)
date added to LUP
2015-05-04 08:38:30
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2017-10-22 03:08:45
@article{b4d46f8e-0a9c-43fd-93fe-f1d97af193dc,
  abstract     = {Inverse associations of coffee and/or tea in relation to hepatocellular carcinoma (HCC) risk have been consistently identified in studies conducted mostly in Asia where consumption patterns of such beverages differ from Europe. In the European Prospective Investigation into Cancer and nutrition (EPIC), we identified 201 HCC cases among 486,799 men/women, after a median follow-up of 11 years. We calculated adjusted hazard ratios (HRs) for HCC incidence in relation to quintiles/categories of coffee/tea intakes. We found that increased coffee and tea intakes were consistently associated with lower HCC risk. The inverse associations were substantial, monotonic and statistically significant. Coffee consumers in the highest compared to the lowest quintile had lower HCC risk by 72% [HR: 0.28; 95% confidence intervals (CIs): 0.16-0.50, p-trend&lt;0.001]. The corresponding association of tea with HCC risk was 0.41 (95% CI: 0.22-0.78, p-trend=0.003). There was no compelling evidence of heterogeneity of these associations across strata of important HCC risk factors, including hepatitis B or hepatitis C status (available in a nested case-control study). The inverse, monotonic associations of coffee intake with HCC were apparent for caffeinated (p-trend=0.009), but not decaffeinated (p-trend=0.45) coffee for which, however, data were available for a fraction of subjects. Results from this multicentre, European cohort study strengthen the existing evidence regarding the inverse association between coffee/tea and HCC risk. Given the apparent lack of heterogeneity of these associations by HCC risk factors and that coffee/tea are universal exposures, our results could have important implications for high HCC risk subjects.},
  author       = {Bamia, Christina and Lagiou, Pagona and Jenab, Mazda and Trichopoulou, Antonia and Fedirko, Veronika and Aleksandrova, Krasimira and Pischon, Tobias and Overvad, Kim and Olsen, Anja and Tjonneland, Anne and Boutron-Ruault, Marie-Christine and Fagherazzi, Guy and Racine, Antoine and Kuhn, Tilman and Boeing, Heiner and Floegel, Anna and Benetou, Vasiliki and Palli, Domenico and Grioni, Sara and Panico, Salvatore and Tumino, Rosario and Vineis, Paolo and Bueno-de-Mesquita, H. B. (as) and Dik, Vincent K. and Bhoo-Pathy, Nirmala and Uiterwaal, Cuno S. P. M. and Weiderpass, Elisabete and Lund, Eiliv and Quiros, J. Ramon and Zamora-Ros, Raul and Molina-Montes, Esther and Chirlaque, Maria-Dolores and Ardanaz, Eva and Dorronsoro, Miren and Lindkvist, Bjoern and Wallström, Peter and Nilsson, Lena Maria and Sund, Malin and Khaw, Kay-Tee and Wareham, Nick and Bradbury, Kathryn E. and Travis, Ruth C. and Ferrari, Pietro and Duarte-Salles, Talita and Stepien, Magdalena and Gunter, Marc and Murphy, Neil and Riboli, Elio and Trichopoulos, Dimitrios},
  issn         = {0020-7136},
  keyword      = {hepatocellular carcinoma,liver cancer,coffee,tea,EPIC},
  language     = {eng},
  number       = {8},
  pages        = {1899--1908},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Coffee, tea and decaffeinated coffee in relation to hepatocellular carcinoma in a European population: Multicentre, prospective cohort study},
  url          = {http://dx.doi.org/10.1002/ijc.29214},
  volume       = {136},
  year         = {2015},
}