Neuron-specific enolase and long-term neurological outcome after OHCA – A validation study
(2021) In Resuscitation 168. p.206-213- Abstract
Aims: To investigate what NSE levels predict long-term neurological prognosis at 24, 48 and 72 hours after ROSC in a cohort of out-of-hospital cardiac arrest and to validate previously suggested NSE cut-offs, including the latest ERC guidelines (2021). Methods: Patients admitted to intensive care units in four hospitals in Southern Sweden between 2014–2018 were included. Blood samples were handled by a single local laboratory. The primary outcome was neurological outcome according to the Cerebral Performance Category (CPC) scale at 2–6 months after cardiac arrest. Results: 368 patients were included for analysis. A ≤2% false positive rate for the prediction of poor neurological outcome was achieved with an NSE cut-off value of >101... (More)
Aims: To investigate what NSE levels predict long-term neurological prognosis at 24, 48 and 72 hours after ROSC in a cohort of out-of-hospital cardiac arrest and to validate previously suggested NSE cut-offs, including the latest ERC guidelines (2021). Methods: Patients admitted to intensive care units in four hospitals in Southern Sweden between 2014–2018 were included. Blood samples were handled by a single local laboratory. The primary outcome was neurological outcome according to the Cerebral Performance Category (CPC) scale at 2–6 months after cardiac arrest. Results: 368 patients were included for analysis. A ≤2% false positive rate for the prediction of poor neurological outcome was achieved with an NSE cut-off value of >101 μg/L at 48 hours and >80 μg/L at 72 hours. The cut-off suggested by the recent ERC guidelines of >60 μg/L at 48 and/or 72 hours generated a false positive rate of 4.3% (95 %CI 0.9–7.4%). Conclusion: A local validation study of the ability of serum levels of neuron-specific enolase to predict long-term poor neurological outcome after out-of-hospital cardiac arrest generated higher cut-offs than suggested by previous publications.
(Less)
- author
- Lissner Östlund, Emilie ; Levin, Helena LU ; Nielsen, Niklas LU ; Frigyesi, Attila LU and Lybeck, Anna LU
- organization
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Biomarker, Cardiac arrest, Neuro prognostication, Neuron-specific enolase, Outcome
- in
- Resuscitation
- volume
- 168
- pages
- 206 - 213
- publisher
- Elsevier
- external identifiers
-
- scopus:85115933013
- pmid:34508799
- ISSN
- 0300-9572
- DOI
- 10.1016/j.resuscitation.2021.09.001
- project
- SweCrit, a critical care biobank
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © 2021 Elsevier B.V.
- id
- 5334cdc1-4331-47bb-a1dc-ed6b2dfe43ba
- date added to LUP
- 2021-10-25 13:40:59
- date last changed
- 2024-09-08 02:57:31
@article{5334cdc1-4331-47bb-a1dc-ed6b2dfe43ba, abstract = {{<p>Aims: To investigate what NSE levels predict long-term neurological prognosis at 24, 48 and 72 hours after ROSC in a cohort of out-of-hospital cardiac arrest and to validate previously suggested NSE cut-offs, including the latest ERC guidelines (2021). Methods: Patients admitted to intensive care units in four hospitals in Southern Sweden between 2014–2018 were included. Blood samples were handled by a single local laboratory. The primary outcome was neurological outcome according to the Cerebral Performance Category (CPC) scale at 2–6 months after cardiac arrest. Results: 368 patients were included for analysis. A ≤2% false positive rate for the prediction of poor neurological outcome was achieved with an NSE cut-off value of >101 μg/L at 48 hours and >80 μg/L at 72 hours. The cut-off suggested by the recent ERC guidelines of >60 μg/L at 48 and/or 72 hours generated a false positive rate of 4.3% (95 %CI 0.9–7.4%). Conclusion: A local validation study of the ability of serum levels of neuron-specific enolase to predict long-term poor neurological outcome after out-of-hospital cardiac arrest generated higher cut-offs than suggested by previous publications.</p>}}, author = {{Lissner Östlund, Emilie and Levin, Helena and Nielsen, Niklas and Frigyesi, Attila and Lybeck, Anna}}, issn = {{0300-9572}}, keywords = {{Biomarker; Cardiac arrest; Neuro prognostication; Neuron-specific enolase; Outcome}}, language = {{eng}}, pages = {{206--213}}, publisher = {{Elsevier}}, series = {{Resuscitation}}, title = {{Neuron-specific enolase and long-term neurological outcome after OHCA – A validation study}}, url = {{http://dx.doi.org/10.1016/j.resuscitation.2021.09.001}}, doi = {{10.1016/j.resuscitation.2021.09.001}}, volume = {{168}}, year = {{2021}}, }