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Deep sequencing and SNP array analyses of pediatric T-cell acute lymphoblastic leukemia reveal NOTCH1 mutations in minor subclones and a high incidence of uniparental isodisomies affecting CDKN2A.

Karrman, Kristina LU ; Castor, Anders LU ; Behrendtz, Mikael; Forestier, Erik; Olsson, Linda LU ; Ehinger, Mats LU ; Biloglav, Andrea LU ; Fioretos, Thoas LU ; Paulsson, Kajsa LU and Johansson, Bertil LU (2015) In Journal of Hematology & Oncology 8(1).
Abstract
Pediatric T-cell acute lymphoblastic leukemia (T-ALL) is a genetically heterogeneous disease that arises in a multistep fashion through acquisition of several genetic aberrations, subsequently giving rise to a malignant, clonal expansion of T-lymphoblasts. The aim of the present study was to identify additional as well as cooperative genetic events in T-ALL.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Hematology & Oncology
volume
8
issue
1
publisher
BioMed Central
external identifiers
  • pmid:25903014
  • wos:000353761500001
  • scopus:84928536653
ISSN
1756-8722
DOI
10.1186/s13045-015-0138-0
language
English
LU publication?
yes
id
63687d33-786a-4277-967a-f2f4c5da657b (old id 5340936)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25903014?dopt=Abstract
date added to LUP
2015-05-02 15:26:18
date last changed
2017-09-24 04:12:38
@article{63687d33-786a-4277-967a-f2f4c5da657b,
  abstract     = {Pediatric T-cell acute lymphoblastic leukemia (T-ALL) is a genetically heterogeneous disease that arises in a multistep fashion through acquisition of several genetic aberrations, subsequently giving rise to a malignant, clonal expansion of T-lymphoblasts. The aim of the present study was to identify additional as well as cooperative genetic events in T-ALL.},
  articleno    = {42},
  author       = {Karrman, Kristina and Castor, Anders and Behrendtz, Mikael and Forestier, Erik and Olsson, Linda and Ehinger, Mats and Biloglav, Andrea and Fioretos, Thoas and Paulsson, Kajsa and Johansson, Bertil},
  issn         = {1756-8722},
  language     = {eng},
  number       = {1},
  publisher    = {BioMed Central},
  series       = {Journal of Hematology & Oncology},
  title        = {Deep sequencing and SNP array analyses of pediatric T-cell acute lymphoblastic leukemia reveal NOTCH1 mutations in minor subclones and a high incidence of uniparental isodisomies affecting CDKN2A.},
  url          = {http://dx.doi.org/10.1186/s13045-015-0138-0},
  volume       = {8},
  year         = {2015},
}