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Normalized activation in the somatosensory cortex 30 years following nerve repair in children- an fMRI study.

Chemnitz, Anette LU ; Weibull, Andreas LU ; Rosén, Birgitta LU ; Andersson, Gert LU ; Dahlin, Lars LU and Björkman, Anders LU (2015) In European Journal of Neuroscience 42(4). p.2022-2027
Abstract
The clinical outcome following a peripheral nerve injury in the upper extremity is generally better in young children than in teenagers and in adults, but the mechanism behind this difference is unknown. In twenty-eight patients with a complete median nerve injury sustained at the ages of 1-13 years (n=13) and 14-20 years (n=15), the cortical activation during tactile finger stimulation of the injured and healthy hands was monitored at a median time since injury of 28 years using functional magnetic resonance imaging (fMRI) at 3 Tesla. The results from the fMRI were compared with the clinical outcome and electroneurography. The cortical activation pattern following sensory stimulation of the median nerve innervated fingers was dependent on... (More)
The clinical outcome following a peripheral nerve injury in the upper extremity is generally better in young children than in teenagers and in adults, but the mechanism behind this difference is unknown. In twenty-eight patients with a complete median nerve injury sustained at the ages of 1-13 years (n=13) and 14-20 years (n=15), the cortical activation during tactile finger stimulation of the injured and healthy hands was monitored at a median time since injury of 28 years using functional magnetic resonance imaging (fMRI) at 3 Tesla. The results from the fMRI were compared with the clinical outcome and electroneurography. The cortical activation pattern following sensory stimulation of the median nerve innervated fingers was dependent on the patient's age at injury. Those injured at a young age (1-13 years) had an activation pattern similar to that of healthy controls. Furthermore, they showed a clinical outcome significantly superior (p=0.001) to the outcome in subjects injured at a later age, however, electroneurographical parameters did not differ between the groups. In subjects injured at age 14-20 years, a more extended activation of the contralateral hemisphere was seen in general. Interestingly, these patients also displayed changes in the ipsilateral hemisphere where a reduced inhibition of somatosensory areas was seen. This loss of ipsilateral inhibition correlated to increasing age at injury as well as to poor recovery of sensory functions in the hand. In conclusion, cerebral changes in both brain hemispheres may explain differences in clinical outcome following a median nerve injury in childhood or adolescence. This article is protected by copyright. All rights reserved. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
European Journal of Neuroscience
volume
42
issue
4
pages
2022 - 2027
publisher
Wiley-Blackwell
external identifiers
  • pmid:25865600
  • wos:000359850600002
  • scopus:84939263205
ISSN
1460-9568
DOI
10.1111/ejn.12917
language
English
LU publication?
yes
id
f6d57816-400e-40b9-b401-6e32202cdc3c (old id 5342063)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25865600?dopt=Abstract
date added to LUP
2015-05-06 11:12:01
date last changed
2017-09-24 03:03:05
@article{f6d57816-400e-40b9-b401-6e32202cdc3c,
  abstract     = {The clinical outcome following a peripheral nerve injury in the upper extremity is generally better in young children than in teenagers and in adults, but the mechanism behind this difference is unknown. In twenty-eight patients with a complete median nerve injury sustained at the ages of 1-13 years (n=13) and 14-20 years (n=15), the cortical activation during tactile finger stimulation of the injured and healthy hands was monitored at a median time since injury of 28 years using functional magnetic resonance imaging (fMRI) at 3 Tesla. The results from the fMRI were compared with the clinical outcome and electroneurography. The cortical activation pattern following sensory stimulation of the median nerve innervated fingers was dependent on the patient's age at injury. Those injured at a young age (1-13 years) had an activation pattern similar to that of healthy controls. Furthermore, they showed a clinical outcome significantly superior (p=0.001) to the outcome in subjects injured at a later age, however, electroneurographical parameters did not differ between the groups. In subjects injured at age 14-20 years, a more extended activation of the contralateral hemisphere was seen in general. Interestingly, these patients also displayed changes in the ipsilateral hemisphere where a reduced inhibition of somatosensory areas was seen. This loss of ipsilateral inhibition correlated to increasing age at injury as well as to poor recovery of sensory functions in the hand. In conclusion, cerebral changes in both brain hemispheres may explain differences in clinical outcome following a median nerve injury in childhood or adolescence. This article is protected by copyright. All rights reserved.},
  author       = {Chemnitz, Anette and Weibull, Andreas and Rosén, Birgitta and Andersson, Gert and Dahlin, Lars and Björkman, Anders},
  issn         = {1460-9568},
  language     = {eng},
  number       = {4},
  pages        = {2022--2027},
  publisher    = {Wiley-Blackwell},
  series       = {European Journal of Neuroscience},
  title        = {Normalized activation in the somatosensory cortex 30 years following nerve repair in children- an fMRI study.},
  url          = {http://dx.doi.org/10.1111/ejn.12917},
  volume       = {42},
  year         = {2015},
}