Normalized activation in the somatosensory cortex 30 years following nerve repair in children- an fMRI study.
Chemnitz, Anette LU ; Weibull, Andreas LU ; Rosén, Birgitta LU ; Andersson, Gert LU ; Dahlin, Lars LU
and Björkman, Anders
LU
(2015)
In European Journal of Neuroscience
42(4).
p.2022-2027
- Abstract
- The clinical outcome following a peripheral nerve injury in the upper extremity is generally better in young children than in teenagers and in adults, but the mechanism behind this difference is unknown. In twenty-eight patients with a complete median nerve injury sustained at the ages of 1-13 years (n=13) and 14-20 years (n=15), the cortical activation during tactile finger stimulation of the injured and healthy hands was monitored at a median time since injury of 28 years using functional magnetic resonance imaging (fMRI) at 3 Tesla. The results from the fMRI were compared with the clinical outcome and electroneurography. The cortical activation pattern following sensory stimulation of the median nerve innervated fingers was dependent on... (More)
- The clinical outcome following a peripheral nerve injury in the upper extremity is generally better in young children than in teenagers and in adults, but the mechanism behind this difference is unknown. In twenty-eight patients with a complete median nerve injury sustained at the ages of 1-13 years (n=13) and 14-20 years (n=15), the cortical activation during tactile finger stimulation of the injured and healthy hands was monitored at a median time since injury of 28 years using functional magnetic resonance imaging (fMRI) at 3 Tesla. The results from the fMRI were compared with the clinical outcome and electroneurography. The cortical activation pattern following sensory stimulation of the median nerve innervated fingers was dependent on the patient's age at injury. Those injured at a young age (1-13 years) had an activation pattern similar to that of healthy controls. Furthermore, they showed a clinical outcome significantly superior (p=0.001) to the outcome in subjects injured at a later age, however, electroneurographical parameters did not differ between the groups. In subjects injured at age 14-20 years, a more extended activation of the contralateral hemisphere was seen in general. Interestingly, these patients also displayed changes in the ipsilateral hemisphere where a reduced inhibition of somatosensory areas was seen. This loss of ipsilateral inhibition correlated to increasing age at injury as well as to poor recovery of sensory functions in the hand. In conclusion, cerebral changes in both brain hemispheres may explain differences in clinical outcome following a median nerve injury in childhood or adolescence. This article is protected by copyright. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/5342063
- author
- Chemnitz, Anette
LU
; Weibull, Andreas
LU
; Rosén, Birgitta
LU
; Andersson, Gert
LU
; Dahlin, Lars
LU
and Björkman, Anders
LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- European Journal of Neuroscience
- volume
- 42
- issue
- 4
- pages
- 2022 - 2027
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:25865600
- wos:000359850600002
- scopus:84939263205
- pmid:25865600
- ISSN
- 1460-9568
- DOI
- 10.1111/ejn.12917
- language
- English
- LU publication?
- yes
- id
- f6d57816-400e-40b9-b401-6e32202cdc3c (old id 5342063)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25865600?dopt=Abstract
- date added to LUP
- 2016-04-01 09:56:03
- date last changed
- 2022-05-13 03:02:35
@article{f6d57816-400e-40b9-b401-6e32202cdc3c,
abstract = {{The clinical outcome following a peripheral nerve injury in the upper extremity is generally better in young children than in teenagers and in adults, but the mechanism behind this difference is unknown. In twenty-eight patients with a complete median nerve injury sustained at the ages of 1-13 years (n=13) and 14-20 years (n=15), the cortical activation during tactile finger stimulation of the injured and healthy hands was monitored at a median time since injury of 28 years using functional magnetic resonance imaging (fMRI) at 3 Tesla. The results from the fMRI were compared with the clinical outcome and electroneurography. The cortical activation pattern following sensory stimulation of the median nerve innervated fingers was dependent on the patient's age at injury. Those injured at a young age (1-13 years) had an activation pattern similar to that of healthy controls. Furthermore, they showed a clinical outcome significantly superior (p=0.001) to the outcome in subjects injured at a later age, however, electroneurographical parameters did not differ between the groups. In subjects injured at age 14-20 years, a more extended activation of the contralateral hemisphere was seen in general. Interestingly, these patients also displayed changes in the ipsilateral hemisphere where a reduced inhibition of somatosensory areas was seen. This loss of ipsilateral inhibition correlated to increasing age at injury as well as to poor recovery of sensory functions in the hand. In conclusion, cerebral changes in both brain hemispheres may explain differences in clinical outcome following a median nerve injury in childhood or adolescence. This article is protected by copyright. All rights reserved.}},
author = {{Chemnitz, Anette and Weibull, Andreas and Rosén, Birgitta and Andersson, Gert and Dahlin, Lars and Björkman, Anders}},
issn = {{1460-9568}},
language = {{eng}},
number = {{4}},
pages = {{2022--2027}},
publisher = {{Wiley-Blackwell}},
series = {{European Journal of Neuroscience}},
title = {{Normalized activation in the somatosensory cortex 30 years following nerve repair in children- an fMRI study.}},
url = {{https://lup.lub.lu.se/search/files/1401462/8521365.pdf}},
doi = {{10.1111/ejn.12917}},
volume = {{42}},
year = {{2015}},
}