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Bidirectional plasticity of purkinje cells matches temporal features of learning

Wetmore, Daniel LU ; Jirenhed, Dan-Anders LU ; Rasmussen, Anders LU ; Johansson, Fredrik LU ; Schnitzer, Mark J and Hesslow, Germund LU (2014) In Journal of Neuroscience 34(5). p.1731-1737
Abstract
Many forms of learning require temporally ordered stimuli. In Pavlovian eyeblink conditioning, a conditioned stimulus (CS) must precede the unconditioned stimulus (US) by at least about 100 ms for learning to occur. Conditioned responses are learned and generated by the cerebellum. Recordings from the cerebellar cortex during conditioning have revealed CS-triggered pauses in the firing of Purkinje cells that likely drive the conditioned blinks. The predominant view of the learning mechanism in conditioning is that long-term depression (LTD) at parallel fiber (PF)-Purkinje cell synapses underlies the Purkinje cell pauses. This raises a serious conceptual challenge because LTD is most effectively induced at short CS-US intervals, which do... (More)
Many forms of learning require temporally ordered stimuli. In Pavlovian eyeblink conditioning, a conditioned stimulus (CS) must precede the unconditioned stimulus (US) by at least about 100 ms for learning to occur. Conditioned responses are learned and generated by the cerebellum. Recordings from the cerebellar cortex during conditioning have revealed CS-triggered pauses in the firing of Purkinje cells that likely drive the conditioned blinks. The predominant view of the learning mechanism in conditioning is that long-term depression (LTD) at parallel fiber (PF)-Purkinje cell synapses underlies the Purkinje cell pauses. This raises a serious conceptual challenge because LTD is most effectively induced at short CS-US intervals, which do not support acquisition of eyeblinks. To resolve this discrepancy, we recorded Purkinje cells during conditioning with short or long CS-US intervals. Decerebrated ferrets trained with CS-US intervals ≥150 ms reliably developed Purkinje cell pauses, but training with an interval of 50 ms unexpectedly induced increases in CS-evoked spiking. This bidirectional modulation of Purkinje cell activity offers a basis for the requirement of a minimum CS-US interval for conditioning, but we argue that it cannot be fully explained by LTD, even when previous in vitro studies of stimulus-timing-dependent LTD are taken into account. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cerebellum, Purkinje cells, spike-timing dependent plasticity, conditioning, timing, temporal
in
Journal of Neuroscience
volume
34
issue
5
pages
1731 - 1737
publisher
Society for Neuroscience
external identifiers
  • PMID:24478355
  • WOS:000331455000016
  • Scopus:84893059891
ISSN
1529-2401
DOI
10.1523/JNEUROSCI.2883-13.2014
project
Cognition, Communication and Learning
language
English
LU publication?
yes
id
53e408aa-ce51-453f-aa0f-a88aab714881 (old id 4286535)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24478355?dopt=Abstract
date added to LUP
2014-02-07 10:55:57
date last changed
2017-01-01 03:47:09
@article{53e408aa-ce51-453f-aa0f-a88aab714881,
  abstract     = {Many forms of learning require temporally ordered stimuli. In Pavlovian eyeblink conditioning, a conditioned stimulus (CS) must precede the unconditioned stimulus (US) by at least about 100 ms for learning to occur. Conditioned responses are learned and generated by the cerebellum. Recordings from the cerebellar cortex during conditioning have revealed CS-triggered pauses in the firing of Purkinje cells that likely drive the conditioned blinks. The predominant view of the learning mechanism in conditioning is that long-term depression (LTD) at parallel fiber (PF)-Purkinje cell synapses underlies the Purkinje cell pauses. This raises a serious conceptual challenge because LTD is most effectively induced at short CS-US intervals, which do not support acquisition of eyeblinks. To resolve this discrepancy, we recorded Purkinje cells during conditioning with short or long CS-US intervals. Decerebrated ferrets trained with CS-US intervals ≥150 ms reliably developed Purkinje cell pauses, but training with an interval of 50 ms unexpectedly induced increases in CS-evoked spiking. This bidirectional modulation of Purkinje cell activity offers a basis for the requirement of a minimum CS-US interval for conditioning, but we argue that it cannot be fully explained by LTD, even when previous in vitro studies of stimulus-timing-dependent LTD are taken into account.},
  author       = {Wetmore, Daniel and Jirenhed, Dan-Anders and Rasmussen, Anders and Johansson, Fredrik and Schnitzer, Mark J and Hesslow, Germund},
  issn         = {1529-2401},
  keyword      = {cerebellum,Purkinje cells,spike-timing dependent plasticity,conditioning,timing,temporal},
  language     = {eng},
  number       = {5},
  pages        = {1731--1737},
  publisher    = {Society for Neuroscience},
  series       = {Journal of Neuroscience},
  title        = {Bidirectional plasticity of purkinje cells matches temporal features of learning},
  url          = {http://dx.doi.org/10.1523/JNEUROSCI.2883-13.2014},
  volume       = {34},
  year         = {2014},
}