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Neuroblastomas and medulloblastomas exhibit more Coxsackie adenovirus receptor expression than gliomas and other brain tumors.

Persson, Annette LU ; Fan, Xiaolong LU ; Salford, Leif LU ; Widegren, Bengt LU and Englund, Elisabet LU (2007) In Neuropathology 27(3). p.233-236
Abstract
Adenoviral vector-mediated treatment is a potential therapy for tumors of the central nervous system. To obtain a significant therapeutic effect by adenoviral vectors, a sufficient infection is required, the power of which depends predominantly on the level of Coxsackie adenovirus receptors. We stained surgical biopsies of central nervous system tumors and neuroblastomas for Coxsackie adenovirus receptors. For gliomas, the level of the receptor was low and markedly variable among individual tumors. By contrast, neuroblastomas and medulloblastomas exhibited a higher degree of Coxsackie adenovirus receptor expression than gliomas and other brain tumors. We conclude that neuroblastomas and medulloblastomas could be suitable for... (More)
Adenoviral vector-mediated treatment is a potential therapy for tumors of the central nervous system. To obtain a significant therapeutic effect by adenoviral vectors, a sufficient infection is required, the power of which depends predominantly on the level of Coxsackie adenovirus receptors. We stained surgical biopsies of central nervous system tumors and neuroblastomas for Coxsackie adenovirus receptors. For gliomas, the level of the receptor was low and markedly variable among individual tumors. By contrast, neuroblastomas and medulloblastomas exhibited a higher degree of Coxsackie adenovirus receptor expression than gliomas and other brain tumors. We conclude that neuroblastomas and medulloblastomas could be suitable for adenovirus-mediated gene therapy. Adverse effects of the treatment, however, must be considered because neurons and reactive astrocytes also express a significant amount of the receptor. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Neuropathology
volume
27
issue
3
pages
233 - 236
publisher
Wiley-Blackwell
external identifiers
  • wos:000246686200004
  • scopus:34249107918
ISSN
0919-6544
DOI
10.1111/j.1440-1789.2007.00767.x
language
English
LU publication?
yes
id
f123a45f-f028-41d7-b397-0039dcb516c8 (old id 540569)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17645237&dopt=Abstract
date added to LUP
2007-12-18 14:01:27
date last changed
2017-04-02 03:24:41
@article{f123a45f-f028-41d7-b397-0039dcb516c8,
  abstract     = {Adenoviral vector-mediated treatment is a potential therapy for tumors of the central nervous system. To obtain a significant therapeutic effect by adenoviral vectors, a sufficient infection is required, the power of which depends predominantly on the level of Coxsackie adenovirus receptors. We stained surgical biopsies of central nervous system tumors and neuroblastomas for Coxsackie adenovirus receptors. For gliomas, the level of the receptor was low and markedly variable among individual tumors. By contrast, neuroblastomas and medulloblastomas exhibited a higher degree of Coxsackie adenovirus receptor expression than gliomas and other brain tumors. We conclude that neuroblastomas and medulloblastomas could be suitable for adenovirus-mediated gene therapy. Adverse effects of the treatment, however, must be considered because neurons and reactive astrocytes also express a significant amount of the receptor.},
  author       = {Persson, Annette and Fan, Xiaolong and Salford, Leif and Widegren, Bengt and Englund, Elisabet},
  issn         = {0919-6544},
  language     = {eng},
  number       = {3},
  pages        = {233--236},
  publisher    = {Wiley-Blackwell},
  series       = {Neuropathology},
  title        = {Neuroblastomas and medulloblastomas exhibit more Coxsackie adenovirus receptor expression than gliomas and other brain tumors.},
  url          = {http://dx.doi.org/10.1111/j.1440-1789.2007.00767.x},
  volume       = {27},
  year         = {2007},
}