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Diffuse reflectance spectroscopy of liver tissue

Reistad, Nina LU ; Nilsson, Jan LU ; Vilhelmsson Timmermand, Oskar LU ; Sturesson, Christian LU and Andersson-Engels, Stefan LU (2015) SPIE Biophotonics South America 2015 In [Host publication title missing] 9531. p.95314-95314
Abstract
Diffuse reflectance spectroscopy (DRS) with a fiber-optic contact probe is a cost-effective, rapid, and non-invasive optical method used to extract diagnosis information of tissue. By combining commercially available VIS- and NIR-spectrometers with various fiber-optic contact-probes, we have access to the full wavelength range from around 400 to 1600 nm. Using this flexible and portable spectroscopy system, we have acquired ex-vivo DRS-spectra from murine, porcine, and human liver tissue. For extracting the tissue optical properties from the measured spectra, we have employed and compared predictions from two models for light propagation in tissue, diffusion theory model (DT) and Monte Carlo simulations (MC).

The focus in this... (More)
Diffuse reflectance spectroscopy (DRS) with a fiber-optic contact probe is a cost-effective, rapid, and non-invasive optical method used to extract diagnosis information of tissue. By combining commercially available VIS- and NIR-spectrometers with various fiber-optic contact-probes, we have access to the full wavelength range from around 400 to 1600 nm. Using this flexible and portable spectroscopy system, we have acquired ex-vivo DRS-spectra from murine, porcine, and human liver tissue. For extracting the tissue optical properties from the measured spectra, we have employed and compared predictions from two models for light propagation in tissue, diffusion theory model (DT) and Monte Carlo simulations (MC).

The focus in this work is on the capacity of this DRS-technique in discriminating metastatic tumor tissue from normal liver tissue as well as in assessing and characterizing damage to non-malignant liver tissue induced by preoperative chemotherapy for colorectal liver metastases. (Less)
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author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Diffuse reflectance spectroscopy, liver tissue, optical properties.
in
[Host publication title missing]
volume
9531
pages
10 pages
publisher
SPIE
conference name
SPIE Biophotonics South America 2015
external identifiers
  • wos:000359467600075
  • scopus:84938912498
ISSN
1996-756X
0277-786X
DOI
10.1117/12.2181008
language
English
LU publication?
yes
id
557b6373-aad6-498d-90ba-f23a444e8693 (old id 5410087)
date added to LUP
2015-05-19 12:48:56
date last changed
2017-11-20 15:05:56
@inproceedings{557b6373-aad6-498d-90ba-f23a444e8693,
  abstract     = {Diffuse reflectance spectroscopy (DRS) with a fiber-optic contact probe is a cost-effective, rapid, and non-invasive optical method used to extract diagnosis information of tissue. By combining commercially available VIS- and NIR-spectrometers with various fiber-optic contact-probes, we have access to the full wavelength range from around 400 to 1600 nm. Using this flexible and portable spectroscopy system, we have acquired ex-vivo DRS-spectra from murine, porcine, and human liver tissue. For extracting the tissue optical properties from the measured spectra, we have employed and compared predictions from two models for light propagation in tissue, diffusion theory model (DT) and Monte Carlo simulations (MC).<br/><br>
The focus in this work is on the capacity of this DRS-technique in discriminating metastatic tumor tissue from normal liver tissue as well as in assessing and characterizing damage to non-malignant liver tissue induced by preoperative chemotherapy for colorectal liver metastases.},
  author       = {Reistad, Nina and Nilsson, Jan and Vilhelmsson Timmermand, Oskar and Sturesson, Christian and Andersson-Engels, Stefan},
  booktitle    = {[Host publication title missing]},
  issn         = {1996-756X},
  keyword      = {Diffuse reflectance spectroscopy,liver tissue,optical properties.},
  language     = {eng},
  pages        = {95314--95314},
  publisher    = {SPIE},
  title        = {Diffuse reflectance spectroscopy of liver tissue},
  url          = {http://dx.doi.org/10.1117/12.2181008},
  volume       = {9531},
  year         = {2015},
}