Immunoadsorption for removal of inhibitors: update on treatments in Malmo-Lund between 1980 and 1995
(1998) In Haemophilia 4(1). p.16-20- Abstract
- Treatment of severe bleeding and the performance of surgery in haemophilia patients with inhibitors creates severe problems. It is generally agreed that treatment is most effective if circulating levels of factor VIII/IX can be achieved long enough for control of haemostasis. Immunoadsorption with protein A for the removal of inhibitor has improved treatment for patients with initial inhibitor titres too high to neutralize by infusion alone. This is a summary of our experience in Malmo regarding immunoadsorption and haemostasis. A total of 19 applications with immunoadsorption in 10 patients were performed. On all occasions it was possible to eliminate totally the inhibitor or reduce it to low levels that could easily be neutralized with... (More)
- Treatment of severe bleeding and the performance of surgery in haemophilia patients with inhibitors creates severe problems. It is generally agreed that treatment is most effective if circulating levels of factor VIII/IX can be achieved long enough for control of haemostasis. Immunoadsorption with protein A for the removal of inhibitor has improved treatment for patients with initial inhibitor titres too high to neutralize by infusion alone. This is a summary of our experience in Malmo regarding immunoadsorption and haemostasis. A total of 19 applications with immunoadsorption in 10 patients were performed. On all occasions it was possible to eliminate totally the inhibitor or reduce it to low levels that could easily be neutralized with factor concentrate. Haemostatic levels of coagulation factors could be maintained for 5-9 days in all but one patient. This period was sufficient to stop ongoing haemorrhage or prevent excessive bleeding at surgical interventions. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1113245
- author
- Freiburghaus, Christian LU ; Berntorp, Erik LU ; Ekman, Maj LU ; Gunnarsson, Margoth LU ; Kjellberg, B M and Nilsson, I M
- organization
- publishing date
- 1998
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Haemophilia, factor VIII, factor IX, inhibitors, immunoadsorption
- in
- Haemophilia
- volume
- 4
- issue
- 1
- pages
- 16 - 20
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:9873860
- scopus:0031598270
- ISSN
- 1351-8216
- DOI
- 10.1046/j.1365-2516.1998.00140.x
- language
- English
- LU publication?
- yes
- id
- 54248767-f561-4f8a-a2d3-90081ff9e87d (old id 1113245)
- date added to LUP
- 2016-04-01 12:15:43
- date last changed
- 2022-08-13 21:15:29
@article{54248767-f561-4f8a-a2d3-90081ff9e87d, abstract = {{Treatment of severe bleeding and the performance of surgery in haemophilia patients with inhibitors creates severe problems. It is generally agreed that treatment is most effective if circulating levels of factor VIII/IX can be achieved long enough for control of haemostasis. Immunoadsorption with protein A for the removal of inhibitor has improved treatment for patients with initial inhibitor titres too high to neutralize by infusion alone. This is a summary of our experience in Malmo regarding immunoadsorption and haemostasis. A total of 19 applications with immunoadsorption in 10 patients were performed. On all occasions it was possible to eliminate totally the inhibitor or reduce it to low levels that could easily be neutralized with factor concentrate. Haemostatic levels of coagulation factors could be maintained for 5-9 days in all but one patient. This period was sufficient to stop ongoing haemorrhage or prevent excessive bleeding at surgical interventions.}}, author = {{Freiburghaus, Christian and Berntorp, Erik and Ekman, Maj and Gunnarsson, Margoth and Kjellberg, B M and Nilsson, I M}}, issn = {{1351-8216}}, keywords = {{Haemophilia; factor VIII; factor IX; inhibitors; immunoadsorption}}, language = {{eng}}, number = {{1}}, pages = {{16--20}}, publisher = {{Wiley-Blackwell}}, series = {{Haemophilia}}, title = {{Immunoadsorption for removal of inhibitors: update on treatments in Malmo-Lund between 1980 and 1995}}, url = {{http://dx.doi.org/10.1046/j.1365-2516.1998.00140.x}}, doi = {{10.1046/j.1365-2516.1998.00140.x}}, volume = {{4}}, year = {{1998}}, }