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Molecular methods for identification and characterization of novel papillomaviruses.

Kocjan, Boštjan J; Bzhalava, Davit LU ; Forslund, Ola LU ; Dillner, Joakim LU and Poljakovic, Mirjana LU (2015) In Clinical Microbiology and Infection 21(9). p.808-816
Abstract
Papillomaviruses (PV) are a remarkably heterogeneous family of small DNA viruses that infect a wide variety of vertebrate species and are etiologically linked with the development of various neoplastic changes of the skin and mucosal epithelia. Based on nucleotide similarity, PVs are hierarchically classified into genera, species and types. Novel human PV (HPV) types are given a unique number only after the whole genome has been cloned and deposited with the International HPV Reference Center. As of March 09, 2015, 200 different HPV types, belonging to 49 species, had been recognized by the International HPV Reference Center. In addition, 131 animal PV types identified from 66 different animal species exist. Recent advances in molecular... (More)
Papillomaviruses (PV) are a remarkably heterogeneous family of small DNA viruses that infect a wide variety of vertebrate species and are etiologically linked with the development of various neoplastic changes of the skin and mucosal epithelia. Based on nucleotide similarity, PVs are hierarchically classified into genera, species and types. Novel human PV (HPV) types are given a unique number only after the whole genome has been cloned and deposited with the International HPV Reference Center. As of March 09, 2015, 200 different HPV types, belonging to 49 species, had been recognized by the International HPV Reference Center. In addition, 131 animal PV types identified from 66 different animal species exist. Recent advances in molecular techniques have resulted in an explosive increase in the identification of novel HPV types and novel subgenomic HPV sequences in the last few years. Among PV genera, the Gamma-PV genus has been growing most rapidly in recent years with 80 completely sequenced HPV types, followed by Alpha- and Beta-PV genera that have 65 and 51 recognized HPV types, respectively. We reviewed in detail the contemporary molecular methods most often used for identification and characterization of novel PV types, including polymerase chain reaction, rolling circle amplification and next generation sequencing. Furthermore, we present a short overview of 12 and 10 novel HPV types recently identified in Sweden and Slovenia, respectively. Finally, an update on the International Human Papillomavirus Reference Center is provided. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Clinical Microbiology and Infection
volume
21
issue
9
pages
808 - 816
publisher
Wiley-Blackwell
external identifiers
  • pmid:26003284
  • wos:000361165300004
  • scopus:84940614340
ISSN
1469-0691
DOI
10.1016/j.cmi.2015.05.011
language
English
LU publication?
yes
id
63dedf11-8ee9-4ba1-a4bc-fc7f19ea5e96 (old id 5442544)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26003284?dopt=Abstract
date added to LUP
2015-06-05 11:59:54
date last changed
2017-09-03 03:31:52
@article{63dedf11-8ee9-4ba1-a4bc-fc7f19ea5e96,
  abstract     = {Papillomaviruses (PV) are a remarkably heterogeneous family of small DNA viruses that infect a wide variety of vertebrate species and are etiologically linked with the development of various neoplastic changes of the skin and mucosal epithelia. Based on nucleotide similarity, PVs are hierarchically classified into genera, species and types. Novel human PV (HPV) types are given a unique number only after the whole genome has been cloned and deposited with the International HPV Reference Center. As of March 09, 2015, 200 different HPV types, belonging to 49 species, had been recognized by the International HPV Reference Center. In addition, 131 animal PV types identified from 66 different animal species exist. Recent advances in molecular techniques have resulted in an explosive increase in the identification of novel HPV types and novel subgenomic HPV sequences in the last few years. Among PV genera, the Gamma-PV genus has been growing most rapidly in recent years with 80 completely sequenced HPV types, followed by Alpha- and Beta-PV genera that have 65 and 51 recognized HPV types, respectively. We reviewed in detail the contemporary molecular methods most often used for identification and characterization of novel PV types, including polymerase chain reaction, rolling circle amplification and next generation sequencing. Furthermore, we present a short overview of 12 and 10 novel HPV types recently identified in Sweden and Slovenia, respectively. Finally, an update on the International Human Papillomavirus Reference Center is provided.},
  author       = {Kocjan, Boštjan J and Bzhalava, Davit and Forslund, Ola and Dillner, Joakim and Poljakovic, Mirjana},
  issn         = {1469-0691},
  language     = {eng},
  number       = {9},
  pages        = {808--816},
  publisher    = {Wiley-Blackwell},
  series       = {Clinical Microbiology and Infection},
  title        = {Molecular methods for identification and characterization of novel papillomaviruses.},
  url          = {http://dx.doi.org/10.1016/j.cmi.2015.05.011},
  volume       = {21},
  year         = {2015},
}