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Systemic Monocytic-MDSCs Are Generated from Monocytes and Correlate with Disease Progression in Breast Cancer Patients.

Bergenfelz, Caroline LU ; Larsson, Anna-Maria LU ; von Stedingk, Kristoffer LU ; Gruvberger, Sofia LU ; Aaltonen, Kristina LU ; Jansson, Sara LU ; Jernström, Helena LU ; Janols, Helena LU ; Wullt, Marlene LU and Bredberg, Anders LU , et al. (2015) In PLoS ONE 10(5).
Abstract
Myeloid-derived suppressor cells (MDSCs) are highly immunosuppressive myeloid cells, which increase in cancer patients. The molecular mechanism behind their generation and function is unclear. Whereas granulocytic-MDSCs correlate with poor overall survival in breast cancer, the presence and relevance of monocytic-MDSCs (Mo-MDSCs) is unknown. Here we report for the first time an enrichment of functional blood Mo-MDSCs in breast cancer patients before they acquire a typical Mo-MDSC surface phenotype. A clear population of Mo-MDSCs with the typical cell surface phenotype (CD14+HLA-DRlow/-CD86low/-CD80low/-CD163low/-) increased significantly first during disease progression and correlated to metastasis to lymph nodes and visceral organs.... (More)
Myeloid-derived suppressor cells (MDSCs) are highly immunosuppressive myeloid cells, which increase in cancer patients. The molecular mechanism behind their generation and function is unclear. Whereas granulocytic-MDSCs correlate with poor overall survival in breast cancer, the presence and relevance of monocytic-MDSCs (Mo-MDSCs) is unknown. Here we report for the first time an enrichment of functional blood Mo-MDSCs in breast cancer patients before they acquire a typical Mo-MDSC surface phenotype. A clear population of Mo-MDSCs with the typical cell surface phenotype (CD14+HLA-DRlow/-CD86low/-CD80low/-CD163low/-) increased significantly first during disease progression and correlated to metastasis to lymph nodes and visceral organs. Furthermore, monocytes, comprising the Mo-MDSC population, from patients with metastatic breast cancer resemble the reprogrammed immunosuppressive monocytes in patients with severe infections, both by their surface and functional phenotype but also at their molecular gene expression profile. Our data suggest that monitoring the Mo-MDSC levels in breast cancer patients may represent a novel and simple biomarker for assessing disease progression. (Less)
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PLoS ONE
volume
10
issue
5
publisher
Public Library of Science
external identifiers
  • pmid:25992611
  • wos:000354921400091
  • scopus:84930621644
ISSN
1932-6203
DOI
10.1371/journal.pone.0127028
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English
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yes
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557e9681-18b2-4809-927e-64e1da98217d (old id 5448534)
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http://www.ncbi.nlm.nih.gov/pubmed/25992611?dopt=Abstract
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2015-06-05 11:22:50
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2017-10-22 04:27:42
@article{557e9681-18b2-4809-927e-64e1da98217d,
  abstract     = {Myeloid-derived suppressor cells (MDSCs) are highly immunosuppressive myeloid cells, which increase in cancer patients. The molecular mechanism behind their generation and function is unclear. Whereas granulocytic-MDSCs correlate with poor overall survival in breast cancer, the presence and relevance of monocytic-MDSCs (Mo-MDSCs) is unknown. Here we report for the first time an enrichment of functional blood Mo-MDSCs in breast cancer patients before they acquire a typical Mo-MDSC surface phenotype. A clear population of Mo-MDSCs with the typical cell surface phenotype (CD14+HLA-DRlow/-CD86low/-CD80low/-CD163low/-) increased significantly first during disease progression and correlated to metastasis to lymph nodes and visceral organs. Furthermore, monocytes, comprising the Mo-MDSC population, from patients with metastatic breast cancer resemble the reprogrammed immunosuppressive monocytes in patients with severe infections, both by their surface and functional phenotype but also at their molecular gene expression profile. Our data suggest that monitoring the Mo-MDSC levels in breast cancer patients may represent a novel and simple biomarker for assessing disease progression.},
  articleno    = {e0127028},
  author       = {Bergenfelz, Caroline and Larsson, Anna-Maria and von Stedingk, Kristoffer and Gruvberger, Sofia and Aaltonen, Kristina and Jansson, Sara and Jernström, Helena and Janols, Helena and Wullt, Marlene and Bredberg, Anders and Rydén, Lisa and Leandersson, Karin},
  issn         = {1932-6203},
  language     = {eng},
  number       = {5},
  publisher    = {Public Library of Science},
  series       = {PLoS ONE},
  title        = {Systemic Monocytic-MDSCs Are Generated from Monocytes and Correlate with Disease Progression in Breast Cancer Patients.},
  url          = {http://dx.doi.org/10.1371/journal.pone.0127028},
  volume       = {10},
  year         = {2015},
}