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Who let the dogs out?: detrimental role of Galectin-3 in hypoperfusion-induced retinal degeneration.

Manouchehrian, Oscar LU ; Arnér, Karin LU ; Deierborg, Tomas LU and Taylor, Linnéa LU (2015) In Journal of Neuroinflammation 12(1).
Abstract
Retinal ischemia results in a progressive degeneration of neurons and a pathological activation of glial cells, resulting in vision loss. In the brain, progressive damage after ischemic insult has been correlated to neuroinflammatory processes involving microglia. Galectin-3 has been shown to mediate microglial responses to ischemic injury in the brain. Therefore, we wanted to explore the contribution of Galectin-3 (Gal-3) to hypoperfusion-induced retinal degeneration in mice.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Neuroinflammation
volume
12
issue
1
publisher
BioMed Central
external identifiers
  • pmid:25968897
  • wos:000354971000001
  • scopus:84929472009
ISSN
1742-2094
DOI
10.1186/s12974-015-0312-x
language
English
LU publication?
yes
id
33b3ae83-9c8f-4f55-98dd-9ac490384b0b (old id 5453307)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25968897?dopt=Abstract
date added to LUP
2015-06-04 19:17:53
date last changed
2017-08-06 04:22:23
@article{33b3ae83-9c8f-4f55-98dd-9ac490384b0b,
  abstract     = {Retinal ischemia results in a progressive degeneration of neurons and a pathological activation of glial cells, resulting in vision loss. In the brain, progressive damage after ischemic insult has been correlated to neuroinflammatory processes involving microglia. Galectin-3 has been shown to mediate microglial responses to ischemic injury in the brain. Therefore, we wanted to explore the contribution of Galectin-3 (Gal-3) to hypoperfusion-induced retinal degeneration in mice.},
  articleno    = {92},
  author       = {Manouchehrian, Oscar and Arnér, Karin and Deierborg, Tomas and Taylor, Linnéa},
  issn         = {1742-2094},
  language     = {eng},
  number       = {1},
  publisher    = {BioMed Central},
  series       = {Journal of Neuroinflammation},
  title        = {Who let the dogs out?: detrimental role of Galectin-3 in hypoperfusion-induced retinal degeneration.},
  url          = {http://dx.doi.org/10.1186/s12974-015-0312-x},
  volume       = {12},
  year         = {2015},
}