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Elevated Plasma Levels of MMP-12 Are Associated With Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects With Type 2 Diabetes.

Goncalves, Isabel LU ; Bengtsson, Eva LU ; Colhoun, Helen M; Shore, Angela C; Palombo, Carlo; Natali, Andrea; Edsfeldt, Andreas LU ; Dunér, Pontus LU ; Nordin Fredrikson, Gunilla LU and Björkbacka, Harry LU , et al. (2015) In Arteriosclerosis, Thrombosis and Vascular Biology 35(7). p.1723-1731
Abstract
Matrix metalloproteinases (MMPs) degrade extracellular matrix proteins and play important roles in development and tissue repair. They have also been shown to have both protective and pathogenic effects in atherosclerosis, and experimental studies have suggested that MMP-12 contributes to plaque growth and destabilization. The objective of this study was to investigate the associations between circulating MMPs, atherosclerosis burden, and incidence of cardiovascular disease with a particular focus on type 2 diabetes mellitus.
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Contribution to journal
publication status
published
subject
in
Arteriosclerosis, Thrombosis and Vascular Biology
volume
35
issue
7
pages
1723 - 1731
publisher
American Heart Association
external identifiers
  • pmid:25953645
  • wos:000356867300022
  • scopus:84933048933
ISSN
1524-4636
DOI
10.1161/ATVBAHA.115.305631
language
English
LU publication?
yes
id
dc9b310e-30f1-4c3e-895f-46f6c9d58ec2 (old id 5456588)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25953645?dopt=Abstract
date added to LUP
2015-06-02 15:52:10
date last changed
2017-11-05 03:17:40
@article{dc9b310e-30f1-4c3e-895f-46f6c9d58ec2,
  abstract     = {Matrix metalloproteinases (MMPs) degrade extracellular matrix proteins and play important roles in development and tissue repair. They have also been shown to have both protective and pathogenic effects in atherosclerosis, and experimental studies have suggested that MMP-12 contributes to plaque growth and destabilization. The objective of this study was to investigate the associations between circulating MMPs, atherosclerosis burden, and incidence of cardiovascular disease with a particular focus on type 2 diabetes mellitus.},
  author       = {Goncalves, Isabel and Bengtsson, Eva and Colhoun, Helen M and Shore, Angela C and Palombo, Carlo and Natali, Andrea and Edsfeldt, Andreas and Dunér, Pontus and Nordin Fredrikson, Gunilla and Björkbacka, Harry and Östling, Gerd and Aizawa, Kunihiko and Casanova, Francesco and Persson, Margaretha and Gooding, Kim and Strain, David and Kahn, Faisel and Looker, Helen C and Adams, Fiona and Belch, Jill and Pinnoli, Silvia and Venturi, Elena and Kozakova, Michaela and Gan, Li-Ming and Schnecke, Volker and Nilsson, Jan},
  issn         = {1524-4636},
  language     = {eng},
  number       = {7},
  pages        = {1723--1731},
  publisher    = {American Heart Association},
  series       = {Arteriosclerosis, Thrombosis and Vascular Biology},
  title        = {Elevated Plasma Levels of MMP-12 Are Associated With Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects With Type 2 Diabetes.},
  url          = {http://dx.doi.org/10.1161/ATVBAHA.115.305631},
  volume       = {35},
  year         = {2015},
}