Elevated Plasma Levels of MMP-12 Are Associated With Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects With Type 2 Diabetes.
(2015) In Arteriosclerosis, Thrombosis and Vascular Biology 35(7). p.1723-1731- Abstract
- Matrix metalloproteinases (MMPs) degrade extracellular matrix proteins and play important roles in development and tissue repair. They have also been shown to have both protective and pathogenic effects in atherosclerosis, and experimental studies have suggested that MMP-12 contributes to plaque growth and destabilization. The objective of this study was to investigate the associations between circulating MMPs, atherosclerosis burden, and incidence of cardiovascular disease with a particular focus on type 2 diabetes mellitus.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/5456588
- author
- organization
-
- EXODIAB: Excellence of Diabetes Research in Sweden
- EpiHealth: Epidemiology for Health
- Cardiovascular Research - Translational Studies (research group)
- Cardiovascular Research - Immunity and Atherosclerosis (research group)
- Cardiovascular Research - Matrix and Inflammation in Atherosclerosis (research group)
- Internal Medicine - Epidemiology (research group)
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Arteriosclerosis, Thrombosis and Vascular Biology
- volume
- 35
- issue
- 7
- pages
- 1723 - 1731
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- pmid:25953645
- wos:000356867300022
- scopus:84933048933
- pmid:25953645
- ISSN
- 1524-4636
- DOI
- 10.1161/ATVBAHA.115.305631
- language
- English
- LU publication?
- yes
- id
- dc9b310e-30f1-4c3e-895f-46f6c9d58ec2 (old id 5456588)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25953645?dopt=Abstract
- date added to LUP
- 2016-04-01 10:43:22
- date last changed
- 2022-03-04 22:12:31
@article{dc9b310e-30f1-4c3e-895f-46f6c9d58ec2, abstract = {{Matrix metalloproteinases (MMPs) degrade extracellular matrix proteins and play important roles in development and tissue repair. They have also been shown to have both protective and pathogenic effects in atherosclerosis, and experimental studies have suggested that MMP-12 contributes to plaque growth and destabilization. The objective of this study was to investigate the associations between circulating MMPs, atherosclerosis burden, and incidence of cardiovascular disease with a particular focus on type 2 diabetes mellitus.}}, author = {{Goncalves, Isabel and Bengtsson, Eva and Colhoun, Helen M and Shore, Angela C and Palombo, Carlo and Natali, Andrea and Edsfeldt, Andreas and Dunér, Pontus and Nordin Fredrikson, Gunilla and Björkbacka, Harry and Östling, Gerd and Aizawa, Kunihiko and Casanova, Francesco and Persson, Margaretha and Gooding, Kim and Strain, David and Kahn, Faisel and Looker, Helen C and Adams, Fiona and Belch, Jill and Pinnoli, Silvia and Venturi, Elena and Kozakova, Michaela and Gan, Li-Ming and Schnecke, Volker and Nilsson, Jan}}, issn = {{1524-4636}}, language = {{eng}}, number = {{7}}, pages = {{1723--1731}}, publisher = {{Lippincott Williams & Wilkins}}, series = {{Arteriosclerosis, Thrombosis and Vascular Biology}}, title = {{Elevated Plasma Levels of MMP-12 Are Associated With Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects With Type 2 Diabetes.}}, url = {{http://dx.doi.org/10.1161/ATVBAHA.115.305631}}, doi = {{10.1161/ATVBAHA.115.305631}}, volume = {{35}}, year = {{2015}}, }