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Statin-induced anti-proliferative effects via cyclin D1 and p27 in a window-of-opportunity breast cancer trial.

Feldt, Maria LU ; Bjarnadottir, Olöf LU ; Kimbung, Siker LU ; Jirström, Karin LU ; Bendahl, Pär-Ola LU ; Veerla, Srinivas LU ; Grabau, Dorthe LU ; Hedenfalk, Ingrid LU and Borgquist, Signe LU (2015) In Journal of Translational Medicine 13(133).
Abstract
Cholesterol lowering statins have been demonstrated to exert anti-tumoral effects on breast cancer by decreasing proliferation as measured by Ki67. The biological mechanisms behind the anti-proliferative effects remain elusive. The aim of this study was to investigate potential statin-induced effects on the central cell cycle regulators cyclin D1 and p27.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Translational Medicine
volume
13
issue
133
publisher
BioMed Central
external identifiers
  • pmid:25925673
  • scopus:84928896902
  • wos:000369795500001
ISSN
1479-5876
DOI
10.1186/s12967-015-0486-0
language
English
LU publication?
yes
id
713ecc16-f543-48d0-9172-07c1bdc95ac0 (old id 5461793)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25925673?dopt=Abstract
date added to LUP
2015-06-04 11:55:20
date last changed
2017-10-01 04:21:33
@article{713ecc16-f543-48d0-9172-07c1bdc95ac0,
  abstract     = {Cholesterol lowering statins have been demonstrated to exert anti-tumoral effects on breast cancer by decreasing proliferation as measured by Ki67. The biological mechanisms behind the anti-proliferative effects remain elusive. The aim of this study was to investigate potential statin-induced effects on the central cell cycle regulators cyclin D1 and p27.},
  author       = {Feldt, Maria and Bjarnadottir, Olöf and Kimbung, Siker and Jirström, Karin and Bendahl, Pär-Ola and Veerla, Srinivas and Grabau, Dorthe and Hedenfalk, Ingrid and Borgquist, Signe},
  issn         = {1479-5876},
  language     = {eng},
  number       = {133},
  publisher    = {BioMed Central},
  series       = {Journal of Translational Medicine},
  title        = {Statin-induced anti-proliferative effects via cyclin D1 and p27 in a window-of-opportunity breast cancer trial.},
  url          = {http://dx.doi.org/10.1186/s12967-015-0486-0},
  volume       = {13},
  year         = {2015},
}