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High risk of developing dementia in Parkinson’s disease : a Swedish registry-based study

Åström, Daniel Oudin LU ; Simonsen, Jacob ; Raket, Lars Lau LU orcid ; Sgarbi, Simona ; Hellsten, Johan LU ; Hagell, Peter LU ; Norlin, Jenny M. ; Kellerborg, Klas ; Martinez-Martin, Pablo and Odin, Per LU orcid (2022) In Scientific Reports 12(1).
Abstract

Dementia have substantial negative impact on the affected individual, their care partners and society. Persons living with Parkinson’s disease (PwP) are also to a large extent living with dementia. The aim of this study is to estimate time to dementia in PD using data from a large quality register with access to baseline clinical and patient reported data merged with Swedish national health registries. Persons with Parkinson’s disease in the Swedish Neuro Registries/Parkinson’s Disease Swedish PD Registry (PARKreg) in Sweden were included and linked to national health registries and matched by sex and age to controls without PD. Time to dementia was analysed with Cox regression models assuming proportional hazards, with time since... (More)

Dementia have substantial negative impact on the affected individual, their care partners and society. Persons living with Parkinson’s disease (PwP) are also to a large extent living with dementia. The aim of this study is to estimate time to dementia in PD using data from a large quality register with access to baseline clinical and patient reported data merged with Swedish national health registries. Persons with Parkinson’s disease in the Swedish Neuro Registries/Parkinson’s Disease Swedish PD Registry (PARKreg) in Sweden were included and linked to national health registries and matched by sex and age to controls without PD. Time to dementia was analysed with Cox regression models assuming proportional hazards, with time since diagnosis as the underlying time variable. In this large prospective cohort study, PwP had approximately four times higher risk of developing dementia as compared to age and sex-matched controls, a finding which remained after adjusting for potential confounders. The present results underline the high risk of dementia in PD and further emphasize the importance of developing symptomatic and ultimately disease modifying strategies to counteract this part of the non-motor symptomatology in PD.

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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scientific Reports
volume
12
issue
1
article number
16759
publisher
Nature Publishing Group
external identifiers
  • pmid:36202962
  • scopus:85139284995
ISSN
2045-2322
DOI
10.1038/s41598-022-21093-8
language
English
LU publication?
yes
id
552622c1-07c6-4304-b5af-48447ebf4b12
date added to LUP
2022-12-09 11:14:52
date last changed
2024-06-13 12:53:14
@article{552622c1-07c6-4304-b5af-48447ebf4b12,
  abstract     = {{<p>Dementia have substantial negative impact on the affected individual, their care partners and society. Persons living with Parkinson’s disease (PwP) are also to a large extent living with dementia. The aim of this study is to estimate time to dementia in PD using data from a large quality register with access to baseline clinical and patient reported data merged with Swedish national health registries. Persons with Parkinson’s disease in the Swedish Neuro Registries/Parkinson’s Disease Swedish PD Registry (PARKreg) in Sweden were included and linked to national health registries and matched by sex and age to controls without PD. Time to dementia was analysed with Cox regression models assuming proportional hazards, with time since diagnosis as the underlying time variable. In this large prospective cohort study, PwP had approximately four times higher risk of developing dementia as compared to age and sex-matched controls, a finding which remained after adjusting for potential confounders. The present results underline the high risk of dementia in PD and further emphasize the importance of developing symptomatic and ultimately disease modifying strategies to counteract this part of the non-motor symptomatology in PD.</p>}},
  author       = {{Åström, Daniel Oudin and Simonsen, Jacob and Raket, Lars Lau and Sgarbi, Simona and Hellsten, Johan and Hagell, Peter and Norlin, Jenny M. and Kellerborg, Klas and Martinez-Martin, Pablo and Odin, Per}},
  issn         = {{2045-2322}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Scientific Reports}},
  title        = {{High risk of developing dementia in Parkinson’s disease : a Swedish registry-based study}},
  url          = {{http://dx.doi.org/10.1038/s41598-022-21093-8}},
  doi          = {{10.1038/s41598-022-21093-8}},
  volume       = {{12}},
  year         = {{2022}},
}