Advanced

Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer

Phelan, Catherine M.; Kuchenbaecker, Karoline B.; Tyrer, Jonathan P.; Kar, Siddhartha P.; Lawrenson, Kate; Winham, Stacey J.; Dennis, Joe; Pirie, Ailith; Riggan, Marjorie J. and Chornokur, Ganna, et al. (2017) In Nature Genetics 49(5). p.680-691
Abstract

To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC cases and 40,941 controls. We identified nine new susceptibility loci for different EOC histotypes: six for serous EOC histotypes (3q28, 4q32.3, 8q21.11, 10q24.33, 18q11.2 and 22q12.1), two for mucinous EOC (3q22.3 and 9q31.1) and one for endometrioid EOC (5q12.3). We then performed meta-analysis on the results for high-grade serous ovarian cancer with the results from analysis of 31,448 BRCA1 and BRCA2 mutation carriers, including 3,887 mutation carriers with EOC. This identified three additional susceptibility loci at 2q13, 8q24.1 and 12q24.31. Integrated... (More)

To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC cases and 40,941 controls. We identified nine new susceptibility loci for different EOC histotypes: six for serous EOC histotypes (3q28, 4q32.3, 8q21.11, 10q24.33, 18q11.2 and 22q12.1), two for mucinous EOC (3q22.3 and 9q31.1) and one for endometrioid EOC (5q12.3). We then performed meta-analysis on the results for high-grade serous ovarian cancer with the results from analysis of 31,448 BRCA1 and BRCA2 mutation carriers, including 3,887 mutation carriers with EOC. This identified three additional susceptibility loci at 2q13, 8q24.1 and 12q24.31. Integrated analyses of genes and regulatory biofeatures at each locus predicted candidate susceptibility genes, including OBFC1, a new candidate susceptibility gene for low-grade and borderline serous EOC.

(Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nature Genetics
volume
49
issue
5
pages
12 pages
publisher
Nature Publishing Group
external identifiers
  • scopus:85016117389
ISSN
1061-4036
DOI
10.1038/ng.3826
language
English
LU publication?
yes
id
5665921c-919d-402f-a03c-2c0e054f1fdb
alternative location
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612337/pdf/nihms906635.pdf
date added to LUP
2018-02-12 11:05:55
date last changed
2018-08-19 04:41:01
@article{5665921c-919d-402f-a03c-2c0e054f1fdb,
  abstract     = {<p>To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC cases and 40,941 controls. We identified nine new susceptibility loci for different EOC histotypes: six for serous EOC histotypes (3q28, 4q32.3, 8q21.11, 10q24.33, 18q11.2 and 22q12.1), two for mucinous EOC (3q22.3 and 9q31.1) and one for endometrioid EOC (5q12.3). We then performed meta-analysis on the results for high-grade serous ovarian cancer with the results from analysis of 31,448 BRCA1 and BRCA2 mutation carriers, including 3,887 mutation carriers with EOC. This identified three additional susceptibility loci at 2q13, 8q24.1 and 12q24.31. Integrated analyses of genes and regulatory biofeatures at each locus predicted candidate susceptibility genes, including OBFC1, a new candidate susceptibility gene for low-grade and borderline serous EOC.</p>},
  author       = {Phelan, Catherine M. and Kuchenbaecker, Karoline B. and Tyrer, Jonathan P. and Kar, Siddhartha P. and Lawrenson, Kate and Winham, Stacey J. and Dennis, Joe and Pirie, Ailith and Riggan, Marjorie J. and Chornokur, Ganna and Earp, Madalene A. and Lyra, Paulo C. and Lee, Janet M. and Coetzee, Simon and Beesley, Jonathan and McGuffog, Lesley and Soucy, Penny and Dicks, Ed and Lee, Andrew and Barrowdale, Daniel and Lecarpentier, Julie and Leslie, Goska and Aalfs, Cora M. and Aben, Katja K.H. and Adams, Marcia and Adlard, Julian and Andrulis, Irene L. and Anton-Culver, Hoda and Antonenkova, Natalia and Aravantinos, Gerasimos and Arnold, Norbert and Arun, Banu K. and Arver, Brita and Azzollini, Jacopo and Balmaña, Judith and Banerjee, Susana N. and Barjhoux, Laure and Barkardottir, Rosa B. and Bean, Yukie and Beckmann, Matthias W. and Beeghly-Fadiel, Alicia and Benitez, Javier and Bermisheva, Marina and Bernardini, Marcus Q. and Birrer, Michael J. and Borg, Åke and Broberg, Per and Jernetz, Mats and Kannisto, Päivi and Olsson, Håkan and ,  and ,  and ,  and ,  and ,  and , },
  issn         = {1061-4036},
  language     = {eng},
  month        = {05},
  number       = {5},
  pages        = {680--691},
  publisher    = {Nature Publishing Group},
  series       = {Nature Genetics},
  title        = {Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer},
  url          = {http://dx.doi.org/10.1038/ng.3826},
  volume       = {49},
  year         = {2017},
}