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Cognitive decline and risk of dementia in older adults after diagnosis of chronic obstructive pulmonary disease

Rosso, Aldana LU ; Månsson, Tomas LU ; Egervall, Karl LU orcid ; Elmståhl, Sölve LU and Overton, Marieclaire LU (2023) In npj Primary Care Respiratory Medicine 33(1).
Abstract

Cognitive screening has been proposed for older adults diagnosed with chronic obstructive pulmonary disease (COPD). Therefore, we examined the change over time in cognitive function and the risk of incident dementia in older adults after COPD diagnosis. A sample of 3,982 participants from the population-based cohort study Good Aging in Skåne was followed for 19 years, and 317 incident COPD cases were identified. The cognitive domains of episodic memory, executive function, and language were assessed using neuropsychological tests. Mixed models for repeated measures and a Cox model were implemented. Participants performed, on average, worse over time on all neuropsychological tests after COPD diagnosis in comparison to those without... (More)

Cognitive screening has been proposed for older adults diagnosed with chronic obstructive pulmonary disease (COPD). Therefore, we examined the change over time in cognitive function and the risk of incident dementia in older adults after COPD diagnosis. A sample of 3,982 participants from the population-based cohort study Good Aging in Skåne was followed for 19 years, and 317 incident COPD cases were identified. The cognitive domains of episodic memory, executive function, and language were assessed using neuropsychological tests. Mixed models for repeated measures and a Cox model were implemented. Participants performed, on average, worse over time on all neuropsychological tests after COPD diagnosis in comparison to those without COPD, although statistical significance differences were only observed for episodic memory and language. The groups had a comparable risk of developing dementia. In conclusion, our results indicate that cognitive screening in the early stages of COPD may be of limited clinical relevance.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
npj Primary Care Respiratory Medicine
volume
33
issue
1
article number
20
publisher
Nature Publishing Group
external identifiers
  • pmid:37179395
  • scopus:85159738479
ISSN
2055-1010
DOI
10.1038/s41533-023-00342-x
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2023. The Author(s).
id
56cc48ba-efb1-44c6-a9e0-992b680e7445
date added to LUP
2023-08-02 23:58:19
date last changed
2024-04-20 00:06:23
@article{56cc48ba-efb1-44c6-a9e0-992b680e7445,
  abstract     = {{<p>Cognitive screening has been proposed for older adults diagnosed with chronic obstructive pulmonary disease (COPD). Therefore, we examined the change over time in cognitive function and the risk of incident dementia in older adults after COPD diagnosis. A sample of 3,982 participants from the population-based cohort study Good Aging in Skåne was followed for 19 years, and 317 incident COPD cases were identified. The cognitive domains of episodic memory, executive function, and language were assessed using neuropsychological tests. Mixed models for repeated measures and a Cox model were implemented. Participants performed, on average, worse over time on all neuropsychological tests after COPD diagnosis in comparison to those without COPD, although statistical significance differences were only observed for episodic memory and language. The groups had a comparable risk of developing dementia. In conclusion, our results indicate that cognitive screening in the early stages of COPD may be of limited clinical relevance.</p>}},
  author       = {{Rosso, Aldana and Månsson, Tomas and Egervall, Karl and Elmståhl, Sölve and Overton, Marieclaire}},
  issn         = {{2055-1010}},
  language     = {{eng}},
  month        = {{05}},
  number       = {{1}},
  publisher    = {{Nature Publishing Group}},
  series       = {{npj Primary Care Respiratory Medicine}},
  title        = {{Cognitive decline and risk of dementia in older adults after diagnosis of chronic obstructive pulmonary disease}},
  url          = {{http://dx.doi.org/10.1038/s41533-023-00342-x}},
  doi          = {{10.1038/s41533-023-00342-x}},
  volume       = {{33}},
  year         = {{2023}},
}