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Leukotriene D4-induced calcium signaling in human intestinal epithelial cells.

Thodeti, Charles Kumar and Sjölander, Anita LU (2002) 507. p.187-191
Abstract
LTD4 induces a calcium signal that consists of a mobilization from internal stores regulated by PTX-insensitive G protein, Rho, and, an influx across the plasma membrane regulated by PTX-sensitive Gi protein in human intestinal epithelial cells. The LTD4 induced mobilization of Ca2+ is mediated by a PH domain dependent association between PLC-gamma 1 and G beta gamma subunits. This interaction requires Src kinase activity as well as the association of this kinase with PLC-gamma 1, suggesting a G beta gamma mediated recruitment of proteins to the plasma membrane and formation of a signaling complex which is essential for the downstream Ca2+ signal. We found a cAMP-dependent protein kinase activity upstream of tyrosine kinase(s) and... (More)
LTD4 induces a calcium signal that consists of a mobilization from internal stores regulated by PTX-insensitive G protein, Rho, and, an influx across the plasma membrane regulated by PTX-sensitive Gi protein in human intestinal epithelial cells. The LTD4 induced mobilization of Ca2+ is mediated by a PH domain dependent association between PLC-gamma 1 and G beta gamma subunits. This interaction requires Src kinase activity as well as the association of this kinase with PLC-gamma 1, suggesting a G beta gamma mediated recruitment of proteins to the plasma membrane and formation of a signaling complex which is essential for the downstream Ca2+ signal. We found a cAMP-dependent protein kinase activity upstream of tyrosine kinase(s) and downstream of Gi protein, that is essential for LTD4-induced Ca2+ influx. This model of the LTD4-induced Ca2+ signaling pathways in intestinal epithelial cells is outlined schematically in Fig. 1. (Less)
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author
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Chapter in Book/Report/Conference proceeding
publication status
published
subject
host publication
Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 5 (Advances in Experimental Medicine and Biology)
volume
507
pages
187 - 191
publisher
Springer
external identifiers
  • pmid:12664584
  • wos:000181518300029
  • scopus:0038784265
ISSN
0065-2598
ISBN
978-0-306-47283-1
language
English
LU publication?
yes
id
56deddfc-99cf-4db8-9645-a2d2ada11476 (old id 113683)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12664584&dopt=Abstract
date added to LUP
2016-04-01 15:36:17
date last changed
2022-02-27 07:46:52
@inbook{56deddfc-99cf-4db8-9645-a2d2ada11476,
  abstract     = {{LTD4 induces a calcium signal that consists of a mobilization from internal stores regulated by PTX-insensitive G protein, Rho, and, an influx across the plasma membrane regulated by PTX-sensitive Gi protein in human intestinal epithelial cells. The LTD4 induced mobilization of Ca2+ is mediated by a PH domain dependent association between PLC-gamma 1 and G beta gamma subunits. This interaction requires Src kinase activity as well as the association of this kinase with PLC-gamma 1, suggesting a G beta gamma mediated recruitment of proteins to the plasma membrane and formation of a signaling complex which is essential for the downstream Ca2+ signal. We found a cAMP-dependent protein kinase activity upstream of tyrosine kinase(s) and downstream of Gi protein, that is essential for LTD4-induced Ca2+ influx. This model of the LTD4-induced Ca2+ signaling pathways in intestinal epithelial cells is outlined schematically in Fig. 1.}},
  author       = {{Thodeti, Charles Kumar and Sjölander, Anita}},
  booktitle    = {{Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 5 (Advances in Experimental Medicine and Biology)}},
  isbn         = {{978-0-306-47283-1}},
  issn         = {{0065-2598}},
  language     = {{eng}},
  pages        = {{187--191}},
  publisher    = {{Springer}},
  title        = {{Leukotriene D4-induced calcium signaling in human intestinal epithelial cells.}},
  url          = {{http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12664584&dopt=Abstract}},
  volume       = {{507}},
  year         = {{2002}},
}