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Indoor phthalate exposure and contributions to total intake among pregnant women in the SELMA study

Preece, Anna Sofia ; Shu, Huan ; Knutz, Malin ; Krais, Annette M. LU orcid ; Bekö, Gabriel and Bornehag, Carl Gustaf LU (2021) In Indoor Air 31(5). p.1495-1508
Abstract

Phthalates are widely used in consumer products. Exposure to phthalates can lead to adverse health effects in humans, with early-life exposure being of particular concern. Phthalate exposure occurs mainly through ingestion, inhalation, and dermal absorption. However, our understanding of the relative importance of different exposure routes is incomplete. This study estimated the intake of five phthalates from the residential indoor environment for 455 Swedish pregnant women in the SELMA study using phthalate mass fraction in indoor dust and compares these to total daily phthalate intakes back-calculated from phthalate metabolite concentrations in the women's urine. Steady-state models were used to estimate indoor air phthalate... (More)

Phthalates are widely used in consumer products. Exposure to phthalates can lead to adverse health effects in humans, with early-life exposure being of particular concern. Phthalate exposure occurs mainly through ingestion, inhalation, and dermal absorption. However, our understanding of the relative importance of different exposure routes is incomplete. This study estimated the intake of five phthalates from the residential indoor environment for 455 Swedish pregnant women in the SELMA study using phthalate mass fraction in indoor dust and compares these to total daily phthalate intakes back-calculated from phthalate metabolite concentrations in the women's urine. Steady-state models were used to estimate indoor air phthalate concentrations from dust measurements. Intakes from residential dust and air made meaningful contributions to total daily intakes of more volatile di-ethyl phthalate (DEP), di-n-butyl phthalate (DnBP), and di-iso-butyl phthalate (DiBP) (11% of total DEP intake and 28% of total DnBP and DiBP intake combined). Dermal absorption from air was the dominant pathway contributing to the indoor environmental exposure. Residential exposure to less volatile phthalates made minor contributions to total intake. These results suggest that reducing the presence of low molecular weight phthalates in the residential indoor environment can meaningfully reduce phthalate intake among pregnant women.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
daily intake, dermal uptake, dust ingestion, exposure pathways, home, inhalation
in
Indoor Air
volume
31
issue
5
pages
1495 - 1508
publisher
Wiley-Blackwell
external identifiers
  • pmid:33751666
  • scopus:85102237276
ISSN
0905-6947
DOI
10.1111/ina.12813
language
English
LU publication?
yes
id
5734e535-ec0e-4f4a-9f25-7d9969b7f488
date added to LUP
2021-03-29 13:25:02
date last changed
2024-06-16 11:22:01
@article{5734e535-ec0e-4f4a-9f25-7d9969b7f488,
  abstract     = {{<p>Phthalates are widely used in consumer products. Exposure to phthalates can lead to adverse health effects in humans, with early-life exposure being of particular concern. Phthalate exposure occurs mainly through ingestion, inhalation, and dermal absorption. However, our understanding of the relative importance of different exposure routes is incomplete. This study estimated the intake of five phthalates from the residential indoor environment for 455 Swedish pregnant women in the SELMA study using phthalate mass fraction in indoor dust and compares these to total daily phthalate intakes back-calculated from phthalate metabolite concentrations in the women's urine. Steady-state models were used to estimate indoor air phthalate concentrations from dust measurements. Intakes from residential dust and air made meaningful contributions to total daily intakes of more volatile di-ethyl phthalate (DEP), di-n-butyl phthalate (DnBP), and di-iso-butyl phthalate (DiBP) (11% of total DEP intake and 28% of total DnBP and DiBP intake combined). Dermal absorption from air was the dominant pathway contributing to the indoor environmental exposure. Residential exposure to less volatile phthalates made minor contributions to total intake. These results suggest that reducing the presence of low molecular weight phthalates in the residential indoor environment can meaningfully reduce phthalate intake among pregnant women.</p>}},
  author       = {{Preece, Anna Sofia and Shu, Huan and Knutz, Malin and Krais, Annette M. and Bekö, Gabriel and Bornehag, Carl Gustaf}},
  issn         = {{0905-6947}},
  keywords     = {{daily intake; dermal uptake; dust ingestion; exposure pathways; home; inhalation}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{1495--1508}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Indoor Air}},
  title        = {{Indoor phthalate exposure and contributions to total intake among pregnant women in the SELMA study}},
  url          = {{http://dx.doi.org/10.1111/ina.12813}},
  doi          = {{10.1111/ina.12813}},
  volume       = {{31}},
  year         = {{2021}},
}