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Intact parathyroid hormone assay is superior to mid region assay in the EDTA-infusion test in hyperparathyroidism

Bergenfelz, A LU ; Nordén, N E LU and Ahrén, B LU (1991) In Clinica Chimica Acta 197(3). p.35-229
Abstract

We examined the use of an intact parathyroid hormone two-site immunoradiometric assay compared with a mid region parathyroid hormone radioimmunoassay in ethylene diamine tetraacetic acid-infusion test in 15 patients with hyperparathyroidism. During the test, plasma intact parathyroid hormone levels increased by 240 +/- 43%, whereas the plasma levels of mid molecule parathyroid hormone increased by only 65 +/- 17%, which is significantly lower (P less than 0.01). Four patients had no increase in plasma mid molecule parathyroid hormone level but still a large increase in plasma intact parathyroid hormone level (P less than 0.01). Thus, plasma measurement of intact parathyroid hormone is superior to that of mid molecule parathyroid hormone... (More)

We examined the use of an intact parathyroid hormone two-site immunoradiometric assay compared with a mid region parathyroid hormone radioimmunoassay in ethylene diamine tetraacetic acid-infusion test in 15 patients with hyperparathyroidism. During the test, plasma intact parathyroid hormone levels increased by 240 +/- 43%, whereas the plasma levels of mid molecule parathyroid hormone increased by only 65 +/- 17%, which is significantly lower (P less than 0.01). Four patients had no increase in plasma mid molecule parathyroid hormone level but still a large increase in plasma intact parathyroid hormone level (P less than 0.01). Thus, plasma measurement of intact parathyroid hormone is superior to that of mid molecule parathyroid hormone in the ethylene diamine tetraacetic acid-infusion test in patients with hyperparathyroidism.

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published
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keywords
Adult, Aged, Aged, 80 and over, Calcium, Edetic Acid, Female, Humans, Hyperparathyroidism, Immunoradiometric Assay, Infusions, Intravenous, Male, Middle Aged, Parathyroid Hormone, Peptide Fragments, Journal Article
in
Clinica Chimica Acta
volume
197
issue
3
pages
7 pages
publisher
Elsevier
external identifiers
  • scopus:0026101914
ISSN
0009-8981
DOI
10.1016/0009-8981(91)90143-Z
language
English
LU publication?
yes
id
57ce21a0-5859-4113-b227-989cf3bd84ef
date added to LUP
2017-05-10 13:47:54
date last changed
2017-09-20 15:57:36
@article{57ce21a0-5859-4113-b227-989cf3bd84ef,
  abstract     = {<p>We examined the use of an intact parathyroid hormone two-site immunoradiometric assay compared with a mid region parathyroid hormone radioimmunoassay in ethylene diamine tetraacetic acid-infusion test in 15 patients with hyperparathyroidism. During the test, plasma intact parathyroid hormone levels increased by 240 +/- 43%, whereas the plasma levels of mid molecule parathyroid hormone increased by only 65 +/- 17%, which is significantly lower (P less than 0.01). Four patients had no increase in plasma mid molecule parathyroid hormone level but still a large increase in plasma intact parathyroid hormone level (P less than 0.01). Thus, plasma measurement of intact parathyroid hormone is superior to that of mid molecule parathyroid hormone in the ethylene diamine tetraacetic acid-infusion test in patients with hyperparathyroidism.</p>},
  author       = {Bergenfelz, A and Nordén, N E and Ahrén, B},
  issn         = {0009-8981},
  keyword      = {Adult,Aged,Aged, 80 and over,Calcium,Edetic Acid,Female,Humans,Hyperparathyroidism,Immunoradiometric Assay,Infusions, Intravenous,Male,Middle Aged,Parathyroid Hormone,Peptide Fragments,Journal Article},
  language     = {eng},
  month        = {03},
  number       = {3},
  pages        = {35--229},
  publisher    = {Elsevier},
  series       = {Clinica Chimica Acta},
  title        = {Intact parathyroid hormone assay is superior to mid region assay in the EDTA-infusion test in hyperparathyroidism},
  url          = {http://dx.doi.org/10.1016/0009-8981(91)90143-Z},
  volume       = {197},
  year         = {1991},
}