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High prevalence of interstitial lung abnormalities in middle-aged never-smokers

Pesonen, Ida ; Johansson, Fredrik ; Johnsson, Åse ; Blomberg, Anders ; Boijsen, Marianne ; Brandberg, John ; Cederlund, Kerstin ; Egesten, Arne LU ; Emilsson, Össur Ingi and Engvall, Jan E. , et al. (2023) In ERJ open research 9(5).
Abstract

Background Interstitial lung abnormalities (ILA) are incidental findings on chest computed tomography (CT). These patterns can present at an early stage of fibrotic lung disease. Our aim was to estimate the prevalence of ILA in the Swedish population, in particular in never-smokers, and find out its association with demographics, comorbidities and symptoms. Methods Participants were recruited to the Swedish CArdioPulmonary BioImage Study (SCAPIS), a population-based survey including men and women aged 50–64 years performed at six university hospitals in Sweden. CT scan, spirometry and questionnaires were performed. ILA were defined as cysts, ground-glass opacities, reticular abnormality, bronchiectasis and honeycombing. Findings Out of... (More)

Background Interstitial lung abnormalities (ILA) are incidental findings on chest computed tomography (CT). These patterns can present at an early stage of fibrotic lung disease. Our aim was to estimate the prevalence of ILA in the Swedish population, in particular in never-smokers, and find out its association with demographics, comorbidities and symptoms. Methods Participants were recruited to the Swedish CArdioPulmonary BioImage Study (SCAPIS), a population-based survey including men and women aged 50–64 years performed at six university hospitals in Sweden. CT scan, spirometry and questionnaires were performed. ILA were defined as cysts, ground-glass opacities, reticular abnormality, bronchiectasis and honeycombing. Findings Out of 29 521 participants, 14 487 were never-smokers and 14 380 were men. In the whole population, 2870 (9.7%) had ILA of which 134 (0.5%) were fibrotic. In never-smokers, the prevalence was 7.9% of which 0.3% were fibrotic. In the whole population, age, smoking history, chronic bronchitis, cancer, coronary artery calcium score and high-sensitive C-reactive protein were associated with ILA. Both ILA and fibrotic ILA were associated with restrictive spirometric pattern and impaired diffusing capacity of the lung for carbon monoxide. However, individuals with ILA did not report more symptoms compared with individuals without ILA. Interpretation ILA are common in a middle-aged Swedish population including never-smokers. ILA may be at risk of being underdiagnosed among never-smokers since they are not a target for screening.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
ERJ open research
volume
9
issue
5
article number
00035-2023
publisher
European Respiratory Society
external identifiers
  • scopus:85172772775
  • pmid:37753274
ISSN
2312-0541
DOI
10.1183/23120541.00035-2023
language
English
LU publication?
yes
id
57d5a5b7-2abd-4a13-be44-bd78c82bc6e1
date added to LUP
2023-12-18 09:34:42
date last changed
2024-05-15 00:13:20
@article{57d5a5b7-2abd-4a13-be44-bd78c82bc6e1,
  abstract     = {{<p>Background Interstitial lung abnormalities (ILA) are incidental findings on chest computed tomography (CT). These patterns can present at an early stage of fibrotic lung disease. Our aim was to estimate the prevalence of ILA in the Swedish population, in particular in never-smokers, and find out its association with demographics, comorbidities and symptoms. Methods Participants were recruited to the Swedish CArdioPulmonary BioImage Study (SCAPIS), a population-based survey including men and women aged 50–64 years performed at six university hospitals in Sweden. CT scan, spirometry and questionnaires were performed. ILA were defined as cysts, ground-glass opacities, reticular abnormality, bronchiectasis and honeycombing. Findings Out of 29 521 participants, 14 487 were never-smokers and 14 380 were men. In the whole population, 2870 (9.7%) had ILA of which 134 (0.5%) were fibrotic. In never-smokers, the prevalence was 7.9% of which 0.3% were fibrotic. In the whole population, age, smoking history, chronic bronchitis, cancer, coronary artery calcium score and high-sensitive C-reactive protein were associated with ILA. Both ILA and fibrotic ILA were associated with restrictive spirometric pattern and impaired diffusing capacity of the lung for carbon monoxide. However, individuals with ILA did not report more symptoms compared with individuals without ILA. Interpretation ILA are common in a middle-aged Swedish population including never-smokers. ILA may be at risk of being underdiagnosed among never-smokers since they are not a target for screening.</p>}},
  author       = {{Pesonen, Ida and Johansson, Fredrik and Johnsson, Åse and Blomberg, Anders and Boijsen, Marianne and Brandberg, John and Cederlund, Kerstin and Egesten, Arne and Emilsson, Össur Ingi and Engvall, Jan E. and Frølich, Andreas and Hagström, Emil and Lindberg, Eva and Malinovschi, Andrei and Stenfors, Nikolai and Swahn, Eva and Tanash, Hanan and Themudo, Raquel and Torén, Kjell and Vanfleteren, Lowie E.G.W. and Wollmer, Per and Zaigham, Suneela and Östgren, Carl Johan and Sköld, C. Magnus}},
  issn         = {{2312-0541}},
  language     = {{eng}},
  number       = {{5}},
  publisher    = {{European Respiratory Society}},
  series       = {{ERJ open research}},
  title        = {{High prevalence of interstitial lung abnormalities in middle-aged never-smokers}},
  url          = {{http://dx.doi.org/10.1183/23120541.00035-2023}},
  doi          = {{10.1183/23120541.00035-2023}},
  volume       = {{9}},
  year         = {{2023}},
}