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Deposition of inhaled nanoparticles is reduced in subjects with COPD and correlates with the extent of emphysema : Proof of concept for a novel diagnostic technique

Aaltonen, H. L. LU ; Jakobsson, J. K. LU ; Diaz, S. LU ; Zackrisson, S. LU ; Piitulainen, E. LU ; Löndahl, J. LU and Wollmer, P. LU (2018) In Clinical Physiology and Functional Imaging 38(6). p.1008-1014
Abstract

Background: The diagnosis of chronic obstructive pulmonary disease (COPD) is often based on spirometry, which is not sensitive to early emphysema. We have recently described a method for assessing distal airspace dimensions by measuring recovery of nanoparticles in exhaled air after a single-breath inhalation followed by breath-hold. Recovery refers to the non-deposited particle fraction. The aim of this study was to explore differences in the recovery of exhaled nanoparticles in subjects with COPD and never-smoking controls. A secondary aim was to determine whether recovery correlates with the extent of emphysema. Method: A total of 19 patients with COPD and 19 controls underwent three repeats of single-breath nanoparticle inhalation... (More)

Background: The diagnosis of chronic obstructive pulmonary disease (COPD) is often based on spirometry, which is not sensitive to early emphysema. We have recently described a method for assessing distal airspace dimensions by measuring recovery of nanoparticles in exhaled air after a single-breath inhalation followed by breath-hold. Recovery refers to the non-deposited particle fraction. The aim of this study was to explore differences in the recovery of exhaled nanoparticles in subjects with COPD and never-smoking controls. A secondary aim was to determine whether recovery correlates with the extent of emphysema. Method: A total of 19 patients with COPD and 19 controls underwent three repeats of single-breath nanoparticle inhalation followed by breath-hold. Particle concentrations in the inhaled aerosol, and in an alveolar sample exhaled after breath-hold, were measured to obtain recovery. Findings: The patients with COPD had a significantly higher mean recovery than controls, 0·128 ± 0·063 versus 0·074 ± 0·058; P = 0·010. Also, recovery correlated significantly with computed tomography (CT) densitometry variables (P<0·01) and diffusing capacity for carbon monoxide (DL,CO; P = 0·002). Interpretation: Higher recovery for emphysema patients, relative to controls, is explained by larger diffusion distances in enlarged distal airspaces. The nanoparticle inhalation method shows potential to be developed towards a tool to diagnose emphysema.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
AiDA, COPD, CT densitometry, Emphysema, Nanoparticles, Respiratory diagnostics
in
Clinical Physiology and Functional Imaging
volume
38
issue
6
pages
1008 - 1014
publisher
Wiley Online Library
external identifiers
  • scopus:85045201899
ISSN
1475-0961
DOI
10.1111/cpf.12517
language
English
LU publication?
yes
id
57e5aa7a-5912-41bb-b090-3115e717dd58
date added to LUP
2018-04-23 11:05:43
date last changed
2019-01-10 16:49:48
@article{57e5aa7a-5912-41bb-b090-3115e717dd58,
  abstract     = {<p>Background: The diagnosis of chronic obstructive pulmonary disease (COPD) is often based on spirometry, which is not sensitive to early emphysema. We have recently described a method for assessing distal airspace dimensions by measuring recovery of nanoparticles in exhaled air after a single-breath inhalation followed by breath-hold. Recovery refers to the non-deposited particle fraction. The aim of this study was to explore differences in the recovery of exhaled nanoparticles in subjects with COPD and never-smoking controls. A secondary aim was to determine whether recovery correlates with the extent of emphysema. Method: A total of 19 patients with COPD and 19 controls underwent three repeats of single-breath nanoparticle inhalation followed by breath-hold. Particle concentrations in the inhaled aerosol, and in an alveolar sample exhaled after breath-hold, were measured to obtain recovery. Findings: The patients with COPD had a significantly higher mean recovery than controls, 0·128 ± 0·063 versus 0·074 ± 0·058; P = 0·010. Also, recovery correlated significantly with computed tomography (CT) densitometry variables (P&lt;0·01) and diffusing capacity for carbon monoxide (D<sub>L,CO</sub>; P = 0·002). Interpretation: Higher recovery for emphysema patients, relative to controls, is explained by larger diffusion distances in enlarged distal airspaces. The nanoparticle inhalation method shows potential to be developed towards a tool to diagnose emphysema.</p>},
  author       = {Aaltonen, H. L. and Jakobsson, J. K. and Diaz, S. and Zackrisson, S. and Piitulainen, E. and Löndahl, J. and Wollmer, P.},
  issn         = {1475-0961},
  keyword      = {AiDA,COPD,CT densitometry,Emphysema,Nanoparticles,Respiratory diagnostics},
  language     = {eng},
  number       = {6},
  pages        = {1008--1014},
  publisher    = {Wiley Online Library},
  series       = {Clinical Physiology and Functional Imaging},
  title        = {Deposition of inhaled nanoparticles is reduced in subjects with COPD and correlates with the extent of emphysema : Proof of concept for a novel diagnostic technique},
  url          = {http://dx.doi.org/10.1111/cpf.12517},
  volume       = {38},
  year         = {2018},
}