Ductus venosus blood flow velocity waveform in diabetic pregnancies
(2010) In Ultrasound in Obstetrics & Gynecology 36(3). p.344-349- Abstract
- Objective Maternal diabetes during pregnancy is associated with congenital cardiac malformations and hypertrophic cardiomyopathy. Blood flow in the ductus venosus (DV) has been postulated to reflect cardiac function. The aim of our study was to investigate if diabetic pregnancies exhibit abnormal DV hemodynamics, hence indicating changes in fetal cardiac function. Methods The pulsatility index of the DV (DV-PI) was analyzed retrospectively in 142 diabetic patients and compared to previously published DV-PI reference values from a non-diabetic low-risk population. DV values were then correlated with maternal glycosylated hemoglobin (HbA1c). Results DV-PI was significantly higher in pregnancies complicated by either pre-existing... (More)
- Objective Maternal diabetes during pregnancy is associated with congenital cardiac malformations and hypertrophic cardiomyopathy. Blood flow in the ductus venosus (DV) has been postulated to reflect cardiac function. The aim of our study was to investigate if diabetic pregnancies exhibit abnormal DV hemodynamics, hence indicating changes in fetal cardiac function. Methods The pulsatility index of the DV (DV-PI) was analyzed retrospectively in 142 diabetic patients and compared to previously published DV-PI reference values from a non-diabetic low-risk population. DV values were then correlated with maternal glycosylated hemoglobin (HbA1c). Results DV-PI was significantly higher in pregnancies complicated by either pre-existing insulin-dependent (DM) or gestational diabetes when compared with normal reference values. Increased DV-PI values were still evident in both diabetic groups when neonates that were small-for-gestational age and neonates with pathological umbilical blood flow pattern were excluded from the analysis. In DM pregnancies a statistically significant correlation was found between DV-PI and maternal HbA1c. Conclusion Diabetic pregnancies exhibit increased DV-PI values when compared to a normal low-risk pregnant population, possibly indicating a fetal cardiac effect. Copyright (C) 2010 ISUOG. Published by John Wiley & Sons, Ltd. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1694023
- author
- Stuart, Andrea LU ; Amer-Wåhlin, Isis LU ; Gudmundsson, Saemundur LU ; Marsal, Karel LU ; Thuring, Ann LU and Källén, Karin LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- pulsatility index, large-for-gestational age, diabetes, ductus venosus
- in
- Ultrasound in Obstetrics & Gynecology
- volume
- 36
- issue
- 3
- pages
- 344 - 349
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000282149900015
- scopus:77956224833
- pmid:20127749
- ISSN
- 1469-0705
- DOI
- 10.1002/uog.7573
- language
- English
- LU publication?
- yes
- id
- 588707be-eaa3-4aae-8c7e-e85088809e7b (old id 1694023)
- date added to LUP
- 2016-04-01 13:22:16
- date last changed
- 2023-08-30 14:14:39
@article{588707be-eaa3-4aae-8c7e-e85088809e7b, abstract = {{Objective Maternal diabetes during pregnancy is associated with congenital cardiac malformations and hypertrophic cardiomyopathy. Blood flow in the ductus venosus (DV) has been postulated to reflect cardiac function. The aim of our study was to investigate if diabetic pregnancies exhibit abnormal DV hemodynamics, hence indicating changes in fetal cardiac function. Methods The pulsatility index of the DV (DV-PI) was analyzed retrospectively in 142 diabetic patients and compared to previously published DV-PI reference values from a non-diabetic low-risk population. DV values were then correlated with maternal glycosylated hemoglobin (HbA1c). Results DV-PI was significantly higher in pregnancies complicated by either pre-existing insulin-dependent (DM) or gestational diabetes when compared with normal reference values. Increased DV-PI values were still evident in both diabetic groups when neonates that were small-for-gestational age and neonates with pathological umbilical blood flow pattern were excluded from the analysis. In DM pregnancies a statistically significant correlation was found between DV-PI and maternal HbA1c. Conclusion Diabetic pregnancies exhibit increased DV-PI values when compared to a normal low-risk pregnant population, possibly indicating a fetal cardiac effect. Copyright (C) 2010 ISUOG. Published by John Wiley & Sons, Ltd.}}, author = {{Stuart, Andrea and Amer-Wåhlin, Isis and Gudmundsson, Saemundur and Marsal, Karel and Thuring, Ann and Källén, Karin}}, issn = {{1469-0705}}, keywords = {{pulsatility index; large-for-gestational age; diabetes; ductus venosus}}, language = {{eng}}, number = {{3}}, pages = {{344--349}}, publisher = {{John Wiley & Sons Inc.}}, series = {{Ultrasound in Obstetrics & Gynecology}}, title = {{Ductus venosus blood flow velocity waveform in diabetic pregnancies}}, url = {{http://dx.doi.org/10.1002/uog.7573}}, doi = {{10.1002/uog.7573}}, volume = {{36}}, year = {{2010}}, }