Interactions between polymorphisms in the aryl hydrocarbon receptor signalling pathway and exposure to persistent organochlorine pollutants affect human semen quality.
(2014) In Reproductive Toxicology 49(Jul 30). p.65-73- Abstract
- Persistent organic pollutants (POPs) may affect male reproductive function. Many dioxin-like POPs exert their effects by activation of the aryl hydrocarbon receptor (AHR) signalling pathway. We analysed whether gene-environment interactions between polymorphisms in AHR (R554K) and AHR repressor (AHRR P185A) and serum levels of markers of POP exposure 1,1-bis-(4-chlorophenyl)-2,2-dichloroethene (p,p'-DDE) and 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) are associated with 21 parameters of male reproductive function in 581 proven-fertile European and Greenlandic men. In Greenlandic men, AHR variants significantly modified the association between serum levels of both p,p'-DDE and CB-153 and inhibin B levels, sperm chromatin integrity, and... (More)
- Persistent organic pollutants (POPs) may affect male reproductive function. Many dioxin-like POPs exert their effects by activation of the aryl hydrocarbon receptor (AHR) signalling pathway. We analysed whether gene-environment interactions between polymorphisms in AHR (R554K) and AHR repressor (AHRR P185A) and serum levels of markers of POP exposure 1,1-bis-(4-chlorophenyl)-2,2-dichloroethene (p,p'-DDE) and 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) are associated with 21 parameters of male reproductive function in 581 proven-fertile European and Greenlandic men. In Greenlandic men, AHR variants significantly modified the association between serum levels of both p,p'-DDE and CB-153 and inhibin B levels, sperm chromatin integrity, and seminal zinc levels. In the total cohort, interactions between AHRR variants and serum levels of CB-153 were associated with sperm chromatin integrity and the expression of the pro-apoptotic marker protein Fas. The data indicate that susceptibility to adverse effects of POP exposure on male reproductive function is dependent on polymorphisms in genes involved in AHR signalling. (Less)
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https://lup.lub.lu.se/record/4615701
- author
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Reproductive Toxicology
- volume
- 49
- issue
- Jul 30
- pages
- 65 - 73
- publisher
- Elsevier
- external identifiers
-
- pmid:25084496
- wos:000345257900008
- scopus:84907323511
- pmid:25084496
- ISSN
- 1873-1708
- DOI
- 10.1016/j.reprotox.2014.07.073
- language
- English
- LU publication?
- yes
- id
- 5a0aaef8-c16c-4470-8bec-d661e2b47012 (old id 4615701)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25084496?dopt=Abstract
- date added to LUP
- 2016-04-01 09:57:55
- date last changed
- 2022-04-27 17:17:53
@article{5a0aaef8-c16c-4470-8bec-d661e2b47012, abstract = {{Persistent organic pollutants (POPs) may affect male reproductive function. Many dioxin-like POPs exert their effects by activation of the aryl hydrocarbon receptor (AHR) signalling pathway. We analysed whether gene-environment interactions between polymorphisms in AHR (R554K) and AHR repressor (AHRR P185A) and serum levels of markers of POP exposure 1,1-bis-(4-chlorophenyl)-2,2-dichloroethene (p,p'-DDE) and 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) are associated with 21 parameters of male reproductive function in 581 proven-fertile European and Greenlandic men. In Greenlandic men, AHR variants significantly modified the association between serum levels of both p,p'-DDE and CB-153 and inhibin B levels, sperm chromatin integrity, and seminal zinc levels. In the total cohort, interactions between AHRR variants and serum levels of CB-153 were associated with sperm chromatin integrity and the expression of the pro-apoptotic marker protein Fas. The data indicate that susceptibility to adverse effects of POP exposure on male reproductive function is dependent on polymorphisms in genes involved in AHR signalling.}}, author = {{Brokken, Leon and Lundberg, Johan P and Spanò, M and Manicardi, G C and Pedersen, H S and Struciński, P and Góralczyk, K and Zviezdai, V and Jönsson, Bo A and Bonde, J P and Toft, G and Giwercman, Yvonne and Giwercman, Aleksander}}, issn = {{1873-1708}}, language = {{eng}}, number = {{Jul 30}}, pages = {{65--73}}, publisher = {{Elsevier}}, series = {{Reproductive Toxicology}}, title = {{Interactions between polymorphisms in the aryl hydrocarbon receptor signalling pathway and exposure to persistent organochlorine pollutants affect human semen quality.}}, url = {{http://dx.doi.org/10.1016/j.reprotox.2014.07.073}}, doi = {{10.1016/j.reprotox.2014.07.073}}, volume = {{49}}, year = {{2014}}, }