Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Amino acids predict prognosis in patients with acute dyspnea

Wiklund, Karolin LU ; Gränsbo, Klas LU ; Almgren, Peter LU ; Peyman, Marjaneh LU ; Tegnér, Lena LU ; Toni-Bengtsson, Maria ; Wieloch, Mattias LU and Melander, Olle LU orcid (2021) In BMC Emergency Medicine 21(1).
Abstract

Background: To identify amino acids that can predict risk of 90-day mortality in patients with acute dyspnea. Method: Plasma levels of nine amino acids were analyzed 663 adult patients admitted to the Emergency Department (ED) with acute dyspnea. Cox proportional hazards models were used to examine the relation between amino acid levels and the risk of 90-day mortality. Result: Eighty patients (12.1%) died within 90 days of admission. An “Amino Acid Mortality Risk Score” (AMRS), summing absolute plasma levels of glycine, phenylalanine and valine, demonstrated that among the patients belonging to quartile 1 (Q1) of the AMRS, only 4 patients died, compared to 44 patients in quartile 4. Using Q1 of the AMRS as reference, each increment of... (More)

Background: To identify amino acids that can predict risk of 90-day mortality in patients with acute dyspnea. Method: Plasma levels of nine amino acids were analyzed 663 adult patients admitted to the Emergency Department (ED) with acute dyspnea. Cox proportional hazards models were used to examine the relation between amino acid levels and the risk of 90-day mortality. Result: Eighty patients (12.1%) died within 90 days of admission. An “Amino Acid Mortality Risk Score” (AMRS), summing absolute plasma levels of glycine, phenylalanine and valine, demonstrated that among the patients belonging to quartile 1 (Q1) of the AMRS, only 4 patients died, compared to 44 patients in quartile 4. Using Q1 of the AMRS as reference, each increment of 1 SD in the AMRS was associated with a hazard ratio (HR) of 2.15 for 90-day mortality, and the HR was > 9 times higher in Q4. Conclusion: Glycine, phenylalanine and valine are associated with a risk of 90-day mortality in patients admitted to the ED for acute dyspnea, suggesting that these amino acids may be useful in risk assessments.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Amino acids, Dyspnea, Emergency service, hospital, Glycine, Phenylalanine, Valine
in
BMC Emergency Medicine
volume
21
issue
1
article number
127
publisher
BioMed Central (BMC)
external identifiers
  • pmid:34717541
  • scopus:85118237715
ISSN
1471-227X
DOI
10.1186/s12873-021-00519-y
project
MOVING FROM BIOMARKERS TO MECHANISM ORIENTED PREVENTION OF CARDIOMETABOLIC DISEASE
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2021, The Author(s).
id
5a92128b-6ce7-44ad-8929-4f35df6cdb47
date added to LUP
2021-11-22 11:33:23
date last changed
2024-06-01 20:16:14
@article{5a92128b-6ce7-44ad-8929-4f35df6cdb47,
  abstract     = {{<p>Background: To identify amino acids that can predict risk of 90-day mortality in patients with acute dyspnea. Method: Plasma levels of nine amino acids were analyzed 663 adult patients admitted to the Emergency Department (ED) with acute dyspnea. Cox proportional hazards models were used to examine the relation between amino acid levels and the risk of 90-day mortality. Result: Eighty patients (12.1%) died within 90 days of admission. An “Amino Acid Mortality Risk Score” (AMRS), summing absolute plasma levels of glycine, phenylalanine and valine, demonstrated that among the patients belonging to quartile 1 (Q1) of the AMRS, only 4 patients died, compared to 44 patients in quartile 4. Using Q1 of the AMRS as reference, each increment of 1 SD in the AMRS was associated with a hazard ratio (HR) of 2.15 for 90-day mortality, and the HR was &gt; 9 times higher in Q4. Conclusion: Glycine, phenylalanine and valine are associated with a risk of 90-day mortality in patients admitted to the ED for acute dyspnea, suggesting that these amino acids may be useful in risk assessments.</p>}},
  author       = {{Wiklund, Karolin and Gränsbo, Klas and Almgren, Peter and Peyman, Marjaneh and Tegnér, Lena and Toni-Bengtsson, Maria and Wieloch, Mattias and Melander, Olle}},
  issn         = {{1471-227X}},
  keywords     = {{Amino acids; Dyspnea; Emergency service, hospital; Glycine; Phenylalanine; Valine}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{BMC Emergency Medicine}},
  title        = {{Amino acids predict prognosis in patients with acute dyspnea}},
  url          = {{http://dx.doi.org/10.1186/s12873-021-00519-y}},
  doi          = {{10.1186/s12873-021-00519-y}},
  volume       = {{21}},
  year         = {{2021}},
}