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Metabolic Syndrome Development during Aging with Special Reference to Obesity Without the Metabolic Syndrome

Roos, Vendela; Elmståhl, Sölve LU ; Ingelsson, Erik; Sundström, Johan; Ärnlöv, Johan and Lind, Lars (2017) In Metabolic Syndrome and Related Disorders 15(1). p.36-43
Abstract

Background: Obesity and its associated metabolic complications continue to increase worldwide. We investigated the development of metabolic syndrome (MetS) during aging in relation to body mass index (BMI) and exercise habits. We assigned special emphasis to the metabolic stability in individuals with obesity, but without MetS, a condition often referred to as metabolically healthy obesity. Materials and Methods: Cross-sectional analysis was carried out in a sample of 19,129 men and women aged 45-75 years from the EpiHealth study. In addition, longitudinal analyses were carried out in the ULSAM study (2322 men at baseline followed from age 50 to age 77) and in the PIVUS study (1016 men and women at baseline followed from age 70 to age... (More)

Background: Obesity and its associated metabolic complications continue to increase worldwide. We investigated the development of metabolic syndrome (MetS) during aging in relation to body mass index (BMI) and exercise habits. We assigned special emphasis to the metabolic stability in individuals with obesity, but without MetS, a condition often referred to as metabolically healthy obesity. Materials and Methods: Cross-sectional analysis was carried out in a sample of 19,129 men and women aged 45-75 years from the EpiHealth study. In addition, longitudinal analyses were carried out in the ULSAM study (2322 men at baseline followed from age 50 to age 77) and in the PIVUS study (1016 men and women at baseline followed from age 70 to age 80). Participants were categorized into six groups according to BMI category (normal weight/BMI <25 kg/m2, overweight/BMI 25-30 kg/m2, and obesity/BMI >30 kg/m2) and MetS status (+/-, National Cholesterol Education Program criteria). Results: MetS prevalence and number of MetS components increased with age in all three samples. The PIVUS study showed that high baseline BMI, low baseline physical activity, and increasing BMI during follow-up were related to increasing MetS prevalence and increasing numbers of MetS components during follow-up. One-third to half of individuals initially belonging to the obesity without MetS category acquired MetS during aging. Conclusions: MetS prevalence increased during aging, especially in individuals with high BMI, low level of physical activity, and weight gain. Obesity without MetS was not a stable condition over time as many of those individuals gained metabolic disturbances during aging.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Metabolic syndrome, MHO, obesity
in
Metabolic Syndrome and Related Disorders
volume
15
issue
1
pages
8 pages
publisher
Mary Ann Liebert, Inc.
external identifiers
  • scopus:85012864719
  • wos:000394368100007
ISSN
1540-4196
DOI
10.1089/met.2016.0082
language
English
LU publication?
yes
id
5aacb50c-87ff-4213-b465-f20a168aa798
date added to LUP
2017-02-28 08:00:29
date last changed
2018-04-15 04:41:34
@article{5aacb50c-87ff-4213-b465-f20a168aa798,
  abstract     = {<p>Background: Obesity and its associated metabolic complications continue to increase worldwide. We investigated the development of metabolic syndrome (MetS) during aging in relation to body mass index (BMI) and exercise habits. We assigned special emphasis to the metabolic stability in individuals with obesity, but without MetS, a condition often referred to as metabolically healthy obesity. Materials and Methods: Cross-sectional analysis was carried out in a sample of 19,129 men and women aged 45-75 years from the EpiHealth study. In addition, longitudinal analyses were carried out in the ULSAM study (2322 men at baseline followed from age 50 to age 77) and in the PIVUS study (1016 men and women at baseline followed from age 70 to age 80). Participants were categorized into six groups according to BMI category (normal weight/BMI &lt;25 kg/m<sup>2</sup>, overweight/BMI 25-30 kg/m<sup>2</sup>, and obesity/BMI &gt;30 kg/m<sup>2</sup>) and MetS status (+/-, National Cholesterol Education Program criteria). Results: MetS prevalence and number of MetS components increased with age in all three samples. The PIVUS study showed that high baseline BMI, low baseline physical activity, and increasing BMI during follow-up were related to increasing MetS prevalence and increasing numbers of MetS components during follow-up. One-third to half of individuals initially belonging to the obesity without MetS category acquired MetS during aging. Conclusions: MetS prevalence increased during aging, especially in individuals with high BMI, low level of physical activity, and weight gain. Obesity without MetS was not a stable condition over time as many of those individuals gained metabolic disturbances during aging.</p>},
  author       = {Roos, Vendela and Elmståhl, Sölve and Ingelsson, Erik and Sundström, Johan and Ärnlöv, Johan and Lind, Lars},
  issn         = {1540-4196},
  keyword      = {Metabolic syndrome,MHO,obesity},
  language     = {eng},
  month        = {02},
  number       = {1},
  pages        = {36--43},
  publisher    = {Mary Ann Liebert, Inc.},
  series       = {Metabolic Syndrome and Related Disorders},
  title        = {Metabolic Syndrome Development during Aging with Special Reference to Obesity Without the Metabolic Syndrome},
  url          = {http://dx.doi.org/10.1089/met.2016.0082},
  volume       = {15},
  year         = {2017},
}