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Health-Related Quality of Life After Surgery for Small Intestinal Neuroendocrine Tumours

Milanetto, Anna Caterina ; Nordenström, Erik LU ; Sundlöv, Anna LU orcid and Almquist, Martin LU (2018) In World Journal of Surgery 42(10). p.3231-3239
Abstract

Background: Overall survival for patients with small intestinal neuroendocrine tumours (siNETs) is long, even with metastatic disease, making quality of life issues relevant. The impact of surgery on quality of life is not known. We investigated determinants of health-related quality of life in patients who had undergone surgery for a siNET. Methods: Patients operated for a siNET between 1998 and 2016 at Skåne University Hospital (Lund, Sweden), who were alive in February 2017, were sent two questionnaires constructed by the European Organisation for Research and Treatment of Cancer (EORTC QLQ-C30, EORTC QLQ-GINET21). Global quality of life, physical function, disease-related worries, diarrhoea and endocrine symptoms were evaluated with... (More)

Background: Overall survival for patients with small intestinal neuroendocrine tumours (siNETs) is long, even with metastatic disease, making quality of life issues relevant. The impact of surgery on quality of life is not known. We investigated determinants of health-related quality of life in patients who had undergone surgery for a siNET. Methods: Patients operated for a siNET between 1998 and 2016 at Skåne University Hospital (Lund, Sweden), who were alive in February 2017, were sent two questionnaires constructed by the European Organisation for Research and Treatment of Cancer (EORTC QLQ-C30, EORTC QLQ-GINET21). Global quality of life, physical function, disease-related worries, diarrhoea and endocrine symptoms were evaluated with linear and logistic regression in relation to patient-, tumour- and treatment-related factors. Statistical analysis was performed using STATA 11®. Results: One hundred patients (84%) completed the questionnaires. Women had worse global quality of life (p = 0.019), more disease-related worries (p < 0.001) and endocrine symptoms (p = 0.017) than men. Older age was associated with more disease-related worries (p = 0.007), but fewer endocrine symptoms (p = 0.034). Non-symptomatic tumour versus symptomatic tumour (p = 0.002), and treatment with somatostatin analogues versus no treatment (p = 0.040) were associated with less diarrhoea. Small versus large bowel resection was associated with better global quality of life (p = 0.036) and physical function (p = 0.035). Conclusions: Male gender, younger age, treatment with somatostatin analogues, non-symptomatic tumour, and small intestinal surgery rather than large bowel surgery were associated with better quality of life.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
World Journal of Surgery
volume
42
issue
10
pages
3231 - 3239
publisher
Springer
external identifiers
  • pmid:29717346
  • scopus:85046152457
ISSN
0364-2313
DOI
10.1007/s00268-018-4638-2
language
English
LU publication?
yes
id
5aaf2dbc-4d22-420b-b80c-8e2e6c0e26ee
date added to LUP
2018-05-07 14:47:46
date last changed
2021-09-29 04:54:39
@article{5aaf2dbc-4d22-420b-b80c-8e2e6c0e26ee,
  abstract     = {<p>Background: Overall survival for patients with small intestinal neuroendocrine tumours (siNETs) is long, even with metastatic disease, making quality of life issues relevant. The impact of surgery on quality of life is not known. We investigated determinants of health-related quality of life in patients who had undergone surgery for a siNET. Methods: Patients operated for a siNET between 1998 and 2016 at Skåne University Hospital (Lund, Sweden), who were alive in February 2017, were sent two questionnaires constructed by the European Organisation for Research and Treatment of Cancer (EORTC QLQ-C30, EORTC QLQ-GINET21). Global quality of life, physical function, disease-related worries, diarrhoea and endocrine symptoms were evaluated with linear and logistic regression in relation to patient-, tumour- and treatment-related factors. Statistical analysis was performed using STATA 11<sup>®</sup>. Results: One hundred patients (84%) completed the questionnaires. Women had worse global quality of life (p = 0.019), more disease-related worries (p &lt; 0.001) and endocrine symptoms (p = 0.017) than men. Older age was associated with more disease-related worries (p = 0.007), but fewer endocrine symptoms (p = 0.034). Non-symptomatic tumour versus symptomatic tumour (p = 0.002), and treatment with somatostatin analogues versus no treatment (p = 0.040) were associated with less diarrhoea. Small versus large bowel resection was associated with better global quality of life (p = 0.036) and physical function (p = 0.035). Conclusions: Male gender, younger age, treatment with somatostatin analogues, non-symptomatic tumour, and small intestinal surgery rather than large bowel surgery were associated with better quality of life.</p>},
  author       = {Milanetto, Anna Caterina and Nordenström, Erik and Sundlöv, Anna and Almquist, Martin},
  issn         = {0364-2313},
  language     = {eng},
  month        = {05},
  number       = {10},
  pages        = {3231--3239},
  publisher    = {Springer},
  series       = {World Journal of Surgery},
  title        = {Health-Related Quality of Life After Surgery for Small Intestinal Neuroendocrine Tumours},
  url          = {http://dx.doi.org/10.1007/s00268-018-4638-2},
  doi          = {10.1007/s00268-018-4638-2},
  volume       = {42},
  year         = {2018},
}