Autoantibodies and gastrointestinal symptoms in infertile women in relation to in vitro fertilization
(2013) In BMC Pregnancy and Childbirth 13.- Abstract
- Background: Prior reports suggest a link between gonadotropin-releasing hormone (GnRH) and gastrointestinal function. The aim of the study was to prospectively investigate women subjected to in vitro fertilization (IVF) using the GnRH analog buserelin, taking into account gastrointestinal symptoms and antibody development against buserelin, GnRH, luteinizing hormone (LH), and their receptors. Methods: Gastrointestinal symptoms were registered by the Visual Analogue Scale for Irritable Bowel Syndrome (VAS-IBS) before and after IVF treatment, and five years later. Health-related quality of life was evaluated by the 36-item Short-Form questionnaire (SF-36). ELISA was used for antibody analyses before and after treatment. Data were compared... (More)
- Background: Prior reports suggest a link between gonadotropin-releasing hormone (GnRH) and gastrointestinal function. The aim of the study was to prospectively investigate women subjected to in vitro fertilization (IVF) using the GnRH analog buserelin, taking into account gastrointestinal symptoms and antibody development against buserelin, GnRH, luteinizing hormone (LH), and their receptors. Methods: Gastrointestinal symptoms were registered by the Visual Analogue Scale for Irritable Bowel Syndrome (VAS-IBS) before and after IVF treatment, and five years later. Health-related quality of life was evaluated by the 36-item Short-Form questionnaire (SF-36). ELISA was used for antibody analyses before and after treatment. Data were compared with women from the general population. Results: In total, 124 patients were investigated before and after IVF, and 62 were re-evaluated after five years. Buserelin treatment led to significant impairment of constipation (p = 0.004), nausea and vomiting (p = 0.035), psychological well-being (p = 0.000), and the intestinal symptoms' influence on daily life (p = 0.027). At 5-year follow-up, abdominal pain was worsened (p = 0.041), but psychological well-being was improved (p = 0.036), compared to prior treatment, and 15% had an observable deterioration in gastrointestinal symptoms. None developed severe dysmotility. Patients had higher prevalence of IgG antibodies against LH (p = 0.001) and its receptor (p = 0.016), and IgM antibodies against the GnRH receptor (p = 0.001) prior treatment compared with controls, but no antibody development was observed after IVF. Conclusion: Patients experience gastrointestinal symptoms during buserelin treatment, and abdominal pain is still increased after five years, but buserelin does not increase antibody formation against GnRH, LH or their receptors. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4260645
- author
- Hammar, Oskar LU ; Roth, Bodil LU ; Bengtsson, Mariette LU ; Mandl, Thomas LU and Ohlsson, Bodil LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Abdominal pain, Gastrointestinal symptoms, Gonadotropin-releasing, hormone, In vitro fertilization, Luteinizing hormone
- in
- BMC Pregnancy and Childbirth
- volume
- 13
- article number
- 201
- publisher
- BioMed Central (BMC)
- external identifiers
-
- wos:000329244800002
- scopus:84887066780
- ISSN
- 1471-2393
- DOI
- 10.1186/1471-2393-13-201
- language
- English
- LU publication?
- yes
- id
- 5b3c87ee-2105-4a87-997f-350c20ff3489 (old id 4260645)
- date added to LUP
- 2016-04-01 12:51:00
- date last changed
- 2022-01-27 07:56:01
@article{5b3c87ee-2105-4a87-997f-350c20ff3489,
abstract = {{Background: Prior reports suggest a link between gonadotropin-releasing hormone (GnRH) and gastrointestinal function. The aim of the study was to prospectively investigate women subjected to in vitro fertilization (IVF) using the GnRH analog buserelin, taking into account gastrointestinal symptoms and antibody development against buserelin, GnRH, luteinizing hormone (LH), and their receptors. Methods: Gastrointestinal symptoms were registered by the Visual Analogue Scale for Irritable Bowel Syndrome (VAS-IBS) before and after IVF treatment, and five years later. Health-related quality of life was evaluated by the 36-item Short-Form questionnaire (SF-36). ELISA was used for antibody analyses before and after treatment. Data were compared with women from the general population. Results: In total, 124 patients were investigated before and after IVF, and 62 were re-evaluated after five years. Buserelin treatment led to significant impairment of constipation (p = 0.004), nausea and vomiting (p = 0.035), psychological well-being (p = 0.000), and the intestinal symptoms' influence on daily life (p = 0.027). At 5-year follow-up, abdominal pain was worsened (p = 0.041), but psychological well-being was improved (p = 0.036), compared to prior treatment, and 15% had an observable deterioration in gastrointestinal symptoms. None developed severe dysmotility. Patients had higher prevalence of IgG antibodies against LH (p = 0.001) and its receptor (p = 0.016), and IgM antibodies against the GnRH receptor (p = 0.001) prior treatment compared with controls, but no antibody development was observed after IVF. Conclusion: Patients experience gastrointestinal symptoms during buserelin treatment, and abdominal pain is still increased after five years, but buserelin does not increase antibody formation against GnRH, LH or their receptors.}},
author = {{Hammar, Oskar and Roth, Bodil and Bengtsson, Mariette and Mandl, Thomas and Ohlsson, Bodil}},
issn = {{1471-2393}},
keywords = {{Abdominal pain; Gastrointestinal symptoms; Gonadotropin-releasing; hormone; In vitro fertilization; Luteinizing hormone}},
language = {{eng}},
publisher = {{BioMed Central (BMC)}},
series = {{BMC Pregnancy and Childbirth}},
title = {{Autoantibodies and gastrointestinal symptoms in infertile women in relation to in vitro fertilization}},
url = {{https://lup.lub.lu.se/search/files/3009354/4588760}},
doi = {{10.1186/1471-2393-13-201}},
volume = {{13}},
year = {{2013}},
}