Childhood atopic disorders in relation to placental changes-A systematic review and meta-analysis
Bakoyan, Zaki ; Cao, Yang ; Hansson, Stefan R LU
; Karlsson, Johanna Patriksson
and Lodefalk, Maria
(2024)
In Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
35(5).
p.1-17
- Abstract
Fetal programming may arise from prenatal exposure and increase the risk of diseases later in life, potentially mediated by the placenta. The objective of this systematic review was to summarize and critically evaluate publications describing associations between human placental changes and risk of atopic disorders during childhood. The review adhered to the Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines. The inclusion criteria were original research articles or case reports written in English describing a human placental change in relation to disease occurring in offspring during childhood. The MEDLINE and EMBASE databases were searched for eligible studies. Risk of bias (RoB) was assessed using the... (More)
Fetal programming may arise from prenatal exposure and increase the risk of diseases later in life, potentially mediated by the placenta. The objective of this systematic review was to summarize and critically evaluate publications describing associations between human placental changes and risk of atopic disorders during childhood. The review adhered to the Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines. The inclusion criteria were original research articles or case reports written in English describing a human placental change in relation to disease occurring in offspring during childhood. The MEDLINE and EMBASE databases were searched for eligible studies. Risk of bias (RoB) was assessed using the ROBINS-I tool. The results were pooled both in a narrative way and by a meta-analysis. Nineteen studies were included (n = 12,997 participants). All studies had an overall serious RoB, and publication bias could not be completely ruled out. However, five studies showed that histological chorioamnionitis in preterm-born children was associated with asthma-related problems (pooled odds ratio = 3.25 (95% confidence interval = 2.22-4.75)). In term-born children, a large placenta (≥750 g) increased the risk of being prescribed anti-asthma medications during the first year of life. Placental histone acetylation, DNA methylation, and gene expression differences were found to be associated with different atopic disorders in term-born children. There is some evidence supporting the idea that the placenta can mediate an increased risk of atopic disorders in children. However, further studies are needed to validate the findings, properly control for confounders, and examine potential mechanisms.
(Less)
- author
- Bakoyan, Zaki
; Cao, Yang
; Hansson, Stefan R
LU
; Karlsson, Johanna Patriksson
and Lodefalk, Maria
- organization
- publishing date
- 2024-05
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Humans, Pregnancy, Female, Placenta/pathology, Child, Hypersensitivity, Immediate/epidemiology, Prenatal Exposure Delayed Effects, Infant, Newborn, Fetal Development, Chorioamnionitis/epidemiology, Asthma/epidemiology
- in
- Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
- volume
- 35
- issue
- 5
- article number
- e14141
- pages
- 1 - 17
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:38773752
- scopus:85193731687
- ISSN
- 0905-6157
- DOI
- 10.1111/pai.14141
- language
- English
- LU publication?
- yes
- additional info
- © 2024 The Authors. Pediatric Allergy and Immunology published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.
- id
- 5b4c63e0-9a2b-45bc-b387-fd18ed71c4d0
- date added to LUP
- 2024-05-23 09:50:20
- date last changed
- 2024-06-05 13:23:11
@article{5b4c63e0-9a2b-45bc-b387-fd18ed71c4d0,
abstract = {{<p>Fetal programming may arise from prenatal exposure and increase the risk of diseases later in life, potentially mediated by the placenta. The objective of this systematic review was to summarize and critically evaluate publications describing associations between human placental changes and risk of atopic disorders during childhood. The review adhered to the Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines. The inclusion criteria were original research articles or case reports written in English describing a human placental change in relation to disease occurring in offspring during childhood. The MEDLINE and EMBASE databases were searched for eligible studies. Risk of bias (RoB) was assessed using the ROBINS-I tool. The results were pooled both in a narrative way and by a meta-analysis. Nineteen studies were included (n = 12,997 participants). All studies had an overall serious RoB, and publication bias could not be completely ruled out. However, five studies showed that histological chorioamnionitis in preterm-born children was associated with asthma-related problems (pooled odds ratio = 3.25 (95% confidence interval = 2.22-4.75)). In term-born children, a large placenta (≥750 g) increased the risk of being prescribed anti-asthma medications during the first year of life. Placental histone acetylation, DNA methylation, and gene expression differences were found to be associated with different atopic disorders in term-born children. There is some evidence supporting the idea that the placenta can mediate an increased risk of atopic disorders in children. However, further studies are needed to validate the findings, properly control for confounders, and examine potential mechanisms.</p>}},
author = {{Bakoyan, Zaki and Cao, Yang and Hansson, Stefan R and Karlsson, Johanna Patriksson and Lodefalk, Maria}},
issn = {{0905-6157}},
keywords = {{Humans; Pregnancy; Female; Placenta/pathology; Child; Hypersensitivity, Immediate/epidemiology; Prenatal Exposure Delayed Effects; Infant, Newborn; Fetal Development; Chorioamnionitis/epidemiology; Asthma/epidemiology}},
language = {{eng}},
number = {{5}},
pages = {{1--17}},
publisher = {{Wiley-Blackwell}},
series = {{Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology}},
title = {{Childhood atopic disorders in relation to placental changes-A systematic review and meta-analysis}},
url = {{http://dx.doi.org/10.1111/pai.14141}},
doi = {{10.1111/pai.14141}},
volume = {{35}},
year = {{2024}},
}