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Carbon monoxide as a putative messenger molecule in the feline lower oesophageal sphincter of the cat

Ny, L ; Grundemar, L LU ; Larsson, B ; Alm, P LU ; Ekström, P LU and Andersson, K E LU (1995) In NeuroReport 6(10). p.1389-1393
Abstract

The distribution of the carbon monoxide (CO) producing enzymes haem oxygenase (HO) type 1 and 2 were studied in the feline lower oesophageal sphincter (LOS), as were HO activity and functional effects of CO. HO-2 immunoreactivity was observed in nerve cell bodies in the submucosal and myenteric plexus, nerve fibres, non-neuronal cells surrounding smooth muscle bundles, and in arterial endothelium, HO-1 immunoreactivity was confined to non-neuronal cells in the smooth muscle layer. CO production, indicating HO activity, was demonstrated in tissue homogenates. CO relaxed the LOS, and activated the cyclic GMP system. These results show that HO is present in the LOS, and suggest that CO can be generated by neuronal and non-neuronal... (More)

The distribution of the carbon monoxide (CO) producing enzymes haem oxygenase (HO) type 1 and 2 were studied in the feline lower oesophageal sphincter (LOS), as were HO activity and functional effects of CO. HO-2 immunoreactivity was observed in nerve cell bodies in the submucosal and myenteric plexus, nerve fibres, non-neuronal cells surrounding smooth muscle bundles, and in arterial endothelium, HO-1 immunoreactivity was confined to non-neuronal cells in the smooth muscle layer. CO production, indicating HO activity, was demonstrated in tissue homogenates. CO relaxed the LOS, and activated the cyclic GMP system. These results show that HO is present in the LOS, and suggest that CO can be generated by neuronal and non-neuronal structures and may have a role as a peripheral messenger.

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published
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keywords
Animals, Carbon Monoxide/metabolism, Cats, Cyclic AMP/metabolism, Cyclic GMP/metabolism, Enzyme Inhibitors/pharmacology, Esophagogastric Junction/drug effects, Heme Oxygenase (Decyclizing)/antagonists & inhibitors, Immunohistochemistry, Isoenzymes/antagonists & inhibitors, Male, Microscopy, Confocal, Muscle Contraction/drug effects, Muscle, Smooth/drug effects, Protoporphyrins/pharmacology
in
NeuroReport
volume
6
issue
10
pages
1389 - 1393
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:7488731
  • scopus:0029117837
ISSN
0959-4965
DOI
10.1097/00001756-199507100-00007
language
English
LU publication?
yes
id
5bd69563-e0f8-4a74-8da3-9bf93506c328
date added to LUP
2019-09-03 14:00:01
date last changed
2019-09-08 04:43:18
@article{5bd69563-e0f8-4a74-8da3-9bf93506c328,
  abstract     = {<p>The distribution of the carbon monoxide (CO) producing enzymes haem oxygenase (HO) type 1 and 2 were studied in the feline lower oesophageal sphincter (LOS), as were HO activity and functional effects of CO. HO-2 immunoreactivity was observed in nerve cell bodies in the submucosal and myenteric plexus, nerve fibres, non-neuronal cells surrounding smooth muscle bundles, and in arterial endothelium, HO-1 immunoreactivity was confined to non-neuronal cells in the smooth muscle layer. CO production, indicating HO activity, was demonstrated in tissue homogenates. CO relaxed the LOS, and activated the cyclic GMP system. These results show that HO is present in the LOS, and suggest that CO can be generated by neuronal and non-neuronal structures and may have a role as a peripheral messenger.</p>},
  author       = {Ny, L and Grundemar, L and Larsson, B and Alm, P and Ekström, P and Andersson, K E},
  issn         = {0959-4965},
  language     = {eng},
  number       = {10},
  pages        = {1389--1393},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {NeuroReport},
  title        = {Carbon monoxide as a putative messenger molecule in the feline lower oesophageal sphincter of the cat},
  url          = {http://dx.doi.org/10.1097/00001756-199507100-00007},
  doi          = {10.1097/00001756-199507100-00007},
  volume       = {6},
  year         = {1995},
}