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Effects of sympathetic stimulation on C-fibre response after peripheral nerve compression : an experimental study in the rabbit common peroneal nerve

Shyu, B C; Danielsen, N LU ; Andersson, S A LU and Dahlin, L B LU (1990) In Acta Physiol.Scand 140(2). p.43-237
Abstract

Non-myelinated C-fibre responses during sympathetic trunk stimulation were studied in rabbit common peroneal nerve 2 weeks after the nerve had been subjected to compression at 400 mmHg for 30 min. Our previous studies have demonstrated that during sympathetic trunk stimulation the compound action potential of uninjured somatic C-fibres is characterized by a reduced amplitude and an increased latency. In the present study, nerve compression changed the C-fibre response to sympathetic stimulation. Three out of eight nerves reacted to nerve compression by increased C-fibre compound action potential amplitude in response to sympathetic stimulation. In three other rabbits with compressed nerves the C-fibre action potential amplitude was... (More)

Non-myelinated C-fibre responses during sympathetic trunk stimulation were studied in rabbit common peroneal nerve 2 weeks after the nerve had been subjected to compression at 400 mmHg for 30 min. Our previous studies have demonstrated that during sympathetic trunk stimulation the compound action potential of uninjured somatic C-fibres is characterized by a reduced amplitude and an increased latency. In the present study, nerve compression changed the C-fibre response to sympathetic stimulation. Three out of eight nerves reacted to nerve compression by increased C-fibre compound action potential amplitude in response to sympathetic stimulation. In three other rabbits with compressed nerves the C-fibre action potential amplitude was unchanged, and in the remaining two rabbits the action potential amplitude was decreased during sympathetic stimulation. The action potential latency increased in all tested compressed C-fibres. The phenomenon of increased C-fibre amplitude during sympathetic activation has not been observed in uninjured nerves. As in uninjured nerves, noradrenaline infusion produced an increased C-fibre action potential amplitude and latency in six animals. Sympathetic stimulation did not affect the A-fibre response. These results indicate that sympathetic activity influences the conduction properties in C-fibres of somatic origin and that the response can be changed after a nerve injury. The findings may be of importance for the understanding of pain aggravation in different types of nerve injuries during increased sympathetic activity.

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publication status
published
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keywords
Action Potentials, Animals, Electric Stimulation, Electrophysiology, Female, Male, Nerve Compression Syndromes, Nerve Fibers, Nerve Fibers, Myelinated, Neurons, Norepinephrine, Peroneal Nerve, Rabbits, Sympathetic Nervous System, Journal Article, Research Support, Non-U.S. Gov't
in
Acta Physiol.Scand
volume
140
issue
2
pages
43 - 237
publisher
Wiley-Blackwell
external identifiers
  • scopus:0025000133
ISSN
0001-6772
DOI
10.1111/j.1748-1716.1990.tb08995.x
language
English
LU publication?
yes
id
5cf6a971-1064-4a1f-86d9-ec5e045047b1
date added to LUP
2017-10-13 14:14:37
date last changed
2017-10-15 04:56:13
@article{5cf6a971-1064-4a1f-86d9-ec5e045047b1,
  abstract     = {<p>Non-myelinated C-fibre responses during sympathetic trunk stimulation were studied in rabbit common peroneal nerve 2 weeks after the nerve had been subjected to compression at 400 mmHg for 30 min. Our previous studies have demonstrated that during sympathetic trunk stimulation the compound action potential of uninjured somatic C-fibres is characterized by a reduced amplitude and an increased latency. In the present study, nerve compression changed the C-fibre response to sympathetic stimulation. Three out of eight nerves reacted to nerve compression by increased C-fibre compound action potential amplitude in response to sympathetic stimulation. In three other rabbits with compressed nerves the C-fibre action potential amplitude was unchanged, and in the remaining two rabbits the action potential amplitude was decreased during sympathetic stimulation. The action potential latency increased in all tested compressed C-fibres. The phenomenon of increased C-fibre amplitude during sympathetic activation has not been observed in uninjured nerves. As in uninjured nerves, noradrenaline infusion produced an increased C-fibre action potential amplitude and latency in six animals. Sympathetic stimulation did not affect the A-fibre response. These results indicate that sympathetic activity influences the conduction properties in C-fibres of somatic origin and that the response can be changed after a nerve injury. The findings may be of importance for the understanding of pain aggravation in different types of nerve injuries during increased sympathetic activity.</p>},
  author       = {Shyu, B C and Danielsen, N and Andersson, S A and Dahlin, L B},
  issn         = {0001-6772},
  keyword      = {Action Potentials,Animals,Electric Stimulation,Electrophysiology,Female,Male,Nerve Compression Syndromes,Nerve Fibers,Nerve Fibers, Myelinated,Neurons,Norepinephrine,Peroneal Nerve,Rabbits,Sympathetic Nervous System,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  number       = {2},
  pages        = {43--237},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Physiol.Scand},
  title        = {Effects of sympathetic stimulation on C-fibre response after peripheral nerve compression : an experimental study in the rabbit common peroneal nerve},
  url          = {http://dx.doi.org/10.1111/j.1748-1716.1990.tb08995.x},
  volume       = {140},
  year         = {1990},
}